Placenta disorder

This trial studies women whose water breaks before labor starts, a condition called premature rupture of membranes, at 37 to 42 weeks of pregnancy. Half the participants will have labor induced within 24 hours using a vaginal gel, while the other half will wait up to 24 hours for…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study tests a new once-weekly growth hormone medicine (somapacitan) against a daily one (Norditropin) in 62 children born small who remain short. The goal is to see if the weekly shot works as well and is safe. Children receive injections either once a week or once a day for…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests if a new growth hormone medicine (somapacitan) given once a week works as well as the standard daily growth hormone (Norditropin) for children who are very short due to being born small, or having Turner syndrome, Noonan syndrome, or unknown causes. About 412 chi…

This study tests whether giving melatonin to pregnant women with a severe form of fetal growth restriction can help their babies. The trial will involve 240 women who will take either melatonin or a placebo nightly. Researchers will track baby growth, pregnancy length, and newbor…

This study aimed to see if the drug tolvaptan could help infants with a severe form of polycystic kidney disease (ARPKD) avoid needing dialysis or a kidney transplant in their first year of life. The trial was planned for babies between 28 days and 12 weeks old, but it was withdr…

This study looks at whether giving pasteurized donor milk instead of formula to newborns who need extra feeding helps mothers breastfeed longer. It includes babies born small, late preterm, or to mothers with diabetes. About 112 infants will be randomly assigned to receive donor …

This study looks at whether 3D color ultrasound can accurately detect how deeply the placenta has grown into the uterine wall (placenta accreta spectrum) in pregnant women. Researchers will compare ultrasound images taken before delivery with what doctors see during C-section. Th…

This study looks at whether measuring IL-6 and lactate in cord blood can detect early signs of infection or inflammation in full-term newborns. Researchers will compare 160 women whose fetal heart rate patterns suggest possible inflammation with those whose patterns are normal. I…

This study looks back at medical records from about 40,000 newborns admitted to three hospitals in Quito, Ecuador, between 2008 and 2024. The goal is to understand which factors—like birth weight, gestational age, birth defects, and mother's health—are linked to newborn illness o…

This study looks back at data from nearly 49,000 births to see if epidural or spinal pain relief during labor is linked to infections in mothers or newborns. Researchers will compare women who had this type of pain relief with those who didn't, checking for fevers, chorioamnionit…

This study looks at how doctors trust artificial intelligence (AI) when it estimates a baby's weight during pregnancy. Over 300 clinicians will review ultrasound cases and choose between AI-based or traditional weight estimates. Some doctors will also see how reliable the AI is. …

This study aims to find the genetic changes that cause some women to have repeated molar pregnancies (abnormal growths in the womb). Researchers will analyze DNA from blood and tissue samples of up to 100 women and their relatives. The goal is to discover new genes linked to this…

This pilot study tests whether leaving the placenta in place after delivery (conservative management) is a safe and effective alternative to hysterectomy for women with placenta accreta spectrum, a condition where the placenta grows too deeply into the uterine wall. Four particip…

This study looks at 290 full-term babies who were small at birth due to intrauterine growth restriction (IUGR). Researchers will measure their body fat and muscle using a special machine, and track their growth and feeding for three months. The goal is to find different types of …

This observational study looks at preterm babies born with early fetal growth restriction (poor growth in the womb) to understand how factors like mother's health and blood flow changes in the womb affect the baby's health after birth. Researchers will compare 200 such babies to …

This study observes heart function in 216 newborns born at 35 weeks or later. Researchers will use ultrasound to measure how the heart relaxes and fills with blood, creating normal reference values. They will also check if factors like mother's health or birth conditions affect h…

This study looks at how anxiety during pregnancy may affect the placenta and birth outcomes. Researchers are studying 150 military moms who receive a support program called M-O-M-S, which offers classes and mentor support. The goal is to understand links between stress, inflammat…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study looks at children and teenagers with growth hormone deficiency or who were born small for their age. It tracks how closely they follow their prescribed Norditropin® treatment and whether that affects their final height. The study is observational, meaning no new treatm…