Epidurals and infections: a 49,000-Birth investigation
NCT ID NCT07751666
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study looks back at data from nearly 49,000 births to see if epidural or spinal pain relief during labor is linked to infections in mothers or newborns. Researchers will compare women who had this type of pain relief with those who didn't, checking for fevers, chorioamnionitis, and newborn infections. The goal is to understand whether the pain relief itself raises infection risk or if the fever it can cause leads to extra diagnoses and treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- neuraxial labor analgesia (epidural or combined spinal-epidural)
- What this could lead to
- If a link is found, it could refine how labor pain relief is managed to reduce infection risks for mothers and babies.
- What could go wrong
- This is an observational study, so it can't prove cause and effect. The results may be influenced by other factors and may not apply to all hospitals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 49,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2015
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study participants consisted of parturients and their neonates who delivered at Peking University First Hospital between January 1, 2015 and December 31, 2022.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Delivery year ranging from 2015 to 2022; * Singleton pregnancy with live birth; * Records of labor induction or spontaneous uterine contraction documented in the database, consistent with the definition of planned or attempted vaginal delivery; * Clear documentation of exposure status to labor analgesia; * Availability of key baseline covariates including maternal age and gestational age. Exclusion Criteria: * Multiple pregnancy, fetal death or stillbirth; * Missing data on labor analgesia exposure; * Unavailable key baseline data, precluding inclusion in the primary adjusted model; * Missing database entries for spontaneous uterine contraction or labor induction; such cases were excluded from the primary target cohort, as they were more likely to represent elective cesarean delivery or unplanned vaginal delivery.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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