Periprosthetic joint infection

This trial tests whether a dietary supplement called protocatechuic acid (PCA) can improve health markers in people undergoing revision surgery for a knee prosthetic joint infection. Participants take PCA before and after surgery, and researchers measure changes in immune and met…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study tests a drug called TRL1068 for people with a long-term infection in a hip or knee replacement. The drug works by breaking down the protective layer (biofilm) that bacteria create, making antibiotics more effective. The goal is to cure the infection with a minor proced…

This study compares a single-stage surgery using implants coated with an antibiotic-loaded hydrogel to the standard two-stage surgery for treating chronic hip prosthesis infections. The single-stage approach aims to remove the infected implant and place a new one in the same oper…

This program provides access to the VT-X7 system, which delivers antibiotics directly into the joint through a pump over 7 days, for people with a serious hip or knee infection after joint replacement. It is for patients who have already tried other treatments and have no other o…

This study tests whether giving antibiotics directly into the bone during a standard cleaning surgery can better control joint infections and reduce the need for additional major surgeries. About 100 adults with infected knee or hip replacements will receive this targeted antibio…

This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use eith…

This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the n…

This study looks at 174 adults with painful joint replacements who may have a chronic infection. Researchers are testing a combination of advanced lab tests, imaging, and tissue sampling to see which methods best detect the infection. The goal is to create a more reliable diagnos…

This trial tests whether taking a daily probiotic alongside standard antibiotic treatment after surgery for an infected hip or knee joint can lower the chance of the infection coming back. The study involves 152 adults undergoing revision joint replacement for infection. Half wil…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study is looking for genes that might make some people more likely to get an infection after hip or knee replacement surgery. Researchers will collect blood or saliva samples from 150 people in families with a history of such infections, plus unaffected relatives. The goal i…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…

This study was designed to observe how antibiotics work in patients with knee replacement infections. Researchers planned to measure antibiotic levels in joint fluid after placing a medicated spacer. The study was withdrawn before enrolling any participants, so no results or conc…

This study looks at why people with bone cancer (skeletal sarcoma) get more infections after joint replacement surgery than those with arthritis. Researchers will collect tissue and blood samples from 40 patients to compare immune and bacterial factors. The goal is to understand …