Could a Double-Dose antibiotic cement slash infection risk after hip break?
NCT ID NCT05164081
First seen Mar 17, 2026 · Last updated Jun 19, 2026 · Updated 10 times
Summary
This study compares two types of antibiotic-loaded bone cement used during hip replacement surgery for broken hips. One cement contains a single antibiotic (gentamicin), the other contains two antibiotics (gentamicin and clindamycin). The goal is to see if the dual-antibiotic cement reduces the risk of deep joint infection within one year after surgery. About 7,000 patients aged 60 and older with displaced femoral neck fractures are taking part across multiple hospitals.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Umeå University Hospital
Umeå, Västerbotten County, Sweden
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotic-loaded bone cement (gentamicin with or without clindamycin)
What this could lead to
If it works, this could point toward a better way to prevent serious joint infections after hip fracture surgery, potentially reducing reoperations and deaths.
What could go wrong
This is a large trial, but results may not apply to all patients or hospitals. Adding a second antibiotic could increase side effects or antibiotic resistance without clear benefit.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.