Peripheral neuropathy
MONDO:0005244A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs.
Also known as: neuropathy, peripheral nerve disorder, peripheral neuropathy
1469 clinical trials for this condition and its sub-types, 93 tagged with Peripheral neuropathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral neuropathy
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Hereditary peripheral neuropathy 6 trials · 478 incl. sub-types
65 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Charcot-Marie-Tooth disease 51 trials · 77 incl. sub-types Sub-types →
- Familial amyloid neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
- Proximal spinal muscular atrophy 14 trials · 42 incl. sub-types Sub-types →
- Metachromatic leukodystrophy 20 trials Sub-types →
- Krabbe disease 15 trials Sub-types →
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Chediak-Higashi syndrome 9 trials
- Leigh syndrome 9 trials Sub-types →
- Peroxisome biogenesis disorder 4 trials · 8 incl. sub-types Sub-types →
- Adrenomyeloneuropathy 7 trials
- Cerebrotendinous xanthomatosis 6 trials
- Kearns-Sayre syndrome 5 trials
- Distal hereditary motor neuropathy 0 trials · 4 incl. sub-types Sub-types →
- Hereditary neuropathy with liability to pressure palsies 4 trials
- Mitochondrial neurogastrointestinal encephalomyopathy 4 trials Sub-types →
- Ornithine aminotransferase deficiency 4 trials
- Pyruvate dehydrogenase deficiency 2 trials · 4 incl. sub-types Sub-types →
- NARP syndrome 3 trials
- Biotinidase deficiency 3 trials
- Coenzyme Q10 deficiency 3 trials Sub-types →
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Hereditary motor and sensory neuropathy 3 trials Sub-types →
- Methylmalonic aciduria and homocystinuria type cblC 3 trials
- Mitochondrial DNA depletion syndrome 4a 3 trials
- Abetalipoproteinemia 2 trials
- Fumaric aciduria 2 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 2 trials
- Niemann-Pick disease type B 1 trial
- PRPS1 deficiency disorder 1 trial
- Adult polyglucosan body disease 1 trial
- Familial isolated deficiency of vitamin E 1 trial
- Homocystinuria due to methylene tetrahydrofolate reductase deficiency 1 trial
- Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency 1 trial
- Neuropathy, congenital hypomelinating 0 trials · 1 incl. sub-types Sub-types →
- Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 1 trial Sub-types →
- Charcot-Marie-Tooth disease type 5 0 trials
- EMILIN-1-related connective tissue disease 0 trials
- Finnish type amyloidosis 0 trials
- PHARC syndrome 0 trials
- VPS13A-related neurodegenerative disease 0 trials
- Amyotrophic neuralgia 0 trials
- Ataxia - oculomotor apraxia type 4 0 trials
- Attenuated Chédiak-Higashi syndrome 0 trials
- Beta-mannosidosis 0 trials
- Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome 0 trials
- Congenital trigeminal anesthesia 0 trials
- Familial episodic pain syndrome 0 trials Sub-types →
- Familial recurrent peripheral facial palsy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Hereditary sensory and autonomic neuropathy with spastic paraplegia 0 trials
- Infantile axonal neuropathy 0 trials
- Meralgia paraesthetica, familial 0 trials
- Neurodegeneration with brain iron accumulation 2A 0 trials
- Neuropathy with hearing impairment 0 trials
- Neuropathy, hereditary sensory and autonomic, type IId 0 trials
- Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 0 trials
- Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome 0 trials
- Oxoglutaricaciduria 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
- Primary CD59 deficiency 0 trials
- Progressive demyelinating neuropathy with bilateral striatal necrosis 0 trials
- Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 0 trials
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Neuralgia 238 trials · 383 incl. sub-types
5 sub-types
- Sciatica 46 trials · 68 incl. sub-types Sub-types →
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Post-infectious neuralgia 0 trials · 33 incl. sub-types Sub-types →
- Pudendal neuralgia 9 trials
- Familial episodic pain syndrome 0 trials Sub-types →
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Nerve compression syndrome 24 trials · 207 incl. sub-types
3 sub-types
- Carpal tunnel syndrome 165 trials Sub-types →
- Piriformis syndrome 25 trials
- Meralgia paresthetica 5 trials Sub-types →
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Diabetic neuropathy 181 trials · 192 incl. sub-types
2 sub-types
- Diabetic polyneuropathy 50 trials
- Diabetic autonomic neuropathy 7 trials
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Chemotherapy-induced neuropathy 171 trials
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Polyneuropathy 32 trials · 132 incl. sub-types
10 sub-types
- Polyradiculoneuropathy 1 trial · 64 incl. sub-types Sub-types →
- Chronic polyneuropathy 0 trials · 62 incl. sub-types Sub-types →
- Demyelinating polyneuropathy 2 trials · 62 incl. sub-types Sub-types →
- Critical illness polyneuropathy 39 trials
- Polyneuritis 3 trials
- Toxic polyneuropathy 1 trial · 3 incl. sub-types Sub-types →
- Idiopathic progressive polyneuropathy 0 trials
- Organophosphate-induced delayed polyneuropathy 0 trials
- Paraneoplastic polyneuropathy 0 trials
- Polyneuropathy in collagen vascular disease 0 trials
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Mononeuropathy 4 trials · 111 incl. sub-types
7 sub-types
- Sciatic neuropathy 9 trials · 72 incl. sub-types Sub-types →
- Ulnar neuropathy 7 trials · 21 incl. sub-types Sub-types →
- Peroneal neuropathy 9 trials
- Femoral neuropathy 7 trials
- Radial neuropathy 1 trial Sub-types →
- Tibial neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
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Acquired peripheral neuropathy 0 trials · 95 incl. sub-types
12 sub-types
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Multifocal motor neuropathy 9 trials
- Pudendal neuralgia 9 trials
- POEMS syndrome 8 trials
- Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG 8 trials
- Non-recovering obstetric brachial plexus lesion 6 trials
- Anterior cutaneous nerve entrapment syndrome 2 trials
- Radiation-induced plexopathy 1 trial
- CANOMAD syndrome 0 trials
- Axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy 0 trials
- Neuralgic amyotrophy 0 trials
- Simple cryoglobulinemia 0 trials
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Nerve plexus disorder 0 trials · 75 incl. sub-types
4 sub-types
- Brachial plexus neuropathy 13 trials · 72 incl. sub-types Sub-types →
- Lumbosacral plexus lesion 0 trials · 2 incl. sub-types Sub-types →
- Radiation-induced plexopathy 1 trial
- Nerve plexus neoplasm 0 trials Sub-types →
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Sensory peripheral neuropathy 4 trials · 58 incl. sub-types
1 sub-type
- Hereditary sensory and autonomic neuropathy 52 trials · 54 incl. sub-types Sub-types →
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Traumatic neuropathy 55 trials
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Neuritis 18 trials · 29 incl. sub-types
7 sub-types
- Vestibular neuronitis 9 trials
- Polyneuritis 3 trials
- Brachial plexus neuritis 0 trials Sub-types →
- Mononeuritis simplex 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuritis of upper limb 0 trials Sub-types →
- Neuroretinitis 0 trials
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Peripheral nerve lesion 1 trial · 12 incl. sub-types
4 sub-types
- Femoral neuropathy 7 trials
- Lesion of sciatic nerve 2 trials Sub-types →
- Ulnar nerve lesion 2 trials
- Radial nerve lesion 0 trials
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Autonomic neuropathy 7 trials · 10 incl. sub-types
2 sub-types
- Diabetic autonomic neuropathy 7 trials
- Horner syndrome 0 trials Sub-types →
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Chronic idiopathic neuropathy 5 trials
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Neuropathy, small fiber 4 trials
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Axonal neuropathy 1 trial · 4 incl. sub-types
3 sub-types
- Giant axonal neuropathy 2 trials · 3 incl. sub-types Sub-types →
- Congenital axonal neuropathy with encephalopathy 0 trials
- Infantile axonal neuropathy 0 trials
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Infectious neuropathy 2 trials
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Vasculitic neuropathy 2 trials
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Autoimmune neuropathy 1 trial
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Ischemic neuropathy 1 trial
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Sarcoid neuropathy 1 trial
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Motor peripheral neuropathy 0 trials · 1 incl. sub-types
9 sub-types
- Charcot-Marie-Tooth disease axonal type 2C 1 trial
- Charcot-Marie-Tooth disease type 4G 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- Glossopharyngeal motor neuropathy 0 trials
- Hereditary motor and sensory neuropathy, Okinawa type 0 trials Sub-types →
- Motor nerve neuritis 0 trials Sub-types →
- Neuropathy, hereditary motor and sensory, type 6A 0 trials
- Neuropathy, hereditary motor and sensory, type 6B 0 trials
- Peripheral motor neuropathy, childhood-onset, biotin-responsive 0 trials
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Radiation-induced neuropathy 0 trials · 1 incl. sub-types
1 sub-type
- Radiation-induced plexopathy 1 trial
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Idiopathic small fibers neuropathy 0 trials
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Neuropathy in cryoglobulinemia 0 trials
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Neuropathy in endocrine disorder 0 trials
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Uremic neuropathy 0 trials
Most studied deeper sub-types
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Exercise program shows promise for diabetic nerve damage
Disease control CompletedThis study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New turkish diagnostic tool for carpal tunnel syndrome under study
Diagnosis CompletedThis study aims to translate and test a diagnostic tool called CTS-6 for Turkish-speaking patients with carpal tunnel syndrome. Researchers will enroll 126 adults, including healthy volunteers, people with symptoms, and those already diagnosed. The goal is to ensure the tool is a…
Sponsor: Istanbul University • Aim: Diagnosis
Last updated Aug 01, 2026 00:00 UTC
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Laser test could objectively measure nerve pain for first time
Diagnosis CompletedThis study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…
Sponsor: University of Utah • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC
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Ultrasound may replace nerve tests for carpal tunnel diagnosis
Diagnosis CompletedThis study tested whether ultrasound can accurately diagnose mild to moderate carpal tunnel syndrome (CTS) by measuring the median nerve. Researchers compared ultrasound results with standard nerve tests and checked how they related to pain, symptoms, and quality of life in 75 pe…
Sponsor: Istanbul University • Aim: Diagnosis
Last updated Jun 27, 2026 09:04 UTC
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Ultrasound may spot rare nerve disease CANVAS
Diagnosis CompletedThis study tested whether ultrasound of the nerves can help diagnose CANVAS, a rare genetic disorder that causes balance problems, nerve damage, and dizziness. Researchers measured nerve size in 35 people with confirmed CANVAS and compared them to healthy individuals. The goal wa…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated Jun 27, 2026 08:01 UTC
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Cold therapy may offer relief for Chemotherapy-Induced nerve pain in children
Symptom relief CompletedThis study tests whether wearing cooling gloves and socks can reduce nerve pain and numbness in children aged 7 to 18 who are receiving vincristine chemotherapy for cancers like leukemia and Wilms tumor. The therapy uses adjustable gel packs that wrap around the hands and feet wi…
Sponsor: Koç University • Aim: Symptom relief
Last updated Sep 10, 2026 00:00 UTC
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Simple exercises ease chemo nerve damage in new study
Symptom relief CompletedThis study looked at how common nerve pain is in cancer patients getting chemotherapy and tested if a simple exercise program could help. 282 patients took part, and those who did supervised exercises for 21 days reported less nerve pain than those who got usual care. The results…
Sponsor: Sri Ramachandra Institute of Higher Education and Research • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Can a Nurse's hypnosis over video call ease nerve pain?
Symptom relief CompletedThis study tested whether hypnosis sessions led by a nurse over video call are practical for people with long-term nerve pain. Thirty adults with peripheral neuropathic pain for over a year took part. The goal was to see if patients would complete five sessions and if it helped w…
Sponsor: University Hospital, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Simple exercises may improve balance and health in diabetic nerve damage
Symptom relief CompletedThis study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …
Sponsor: Karamanoğlu Mehmetbey University • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Can simple exercises ease diabetic nerve pain?
Symptom relief CompletedThis study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …
Sponsor: Eastern Mediterranean University • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Exercise showdown: pilates vs gyrotonic for chemo nerve damage
Symptom relief CompletedThis study tested whether Pilates or Gyrotonic exercises can ease nerve pain and reduce fall risk in 100 cancer survivors who have nerve damage from chemotherapy. Participants did one of the two exercise programs. The goal was to see if these exercises improve symptoms like numbn…
Sponsor: MTI University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Squeeze away chemo fatigue? study tests sensory balls and relaxation for cancer patients
Symptom relief CompletedThis study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…
Sponsor: KTO Karatay University • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Vitamin cocktail may soothe chemo nerve damage
Symptom relief CompletedThis study tested a dietary supplement containing ingredients like palmitoylethanolamide, alpha lipoic acid, and several B vitamins to see if it could reduce nerve pain in cancer patients receiving chemotherapy. 71 newly diagnosed patients who had not yet started treatment took e…
Phase 4 • Sponsor: Aristotle University Of Thessaloniki • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Carbon braces may help kids with nerve conditions walk better
Symptom relief CompletedThis study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…
Sponsor: Otto Bock France SNC • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Dancing away chemo nerve pain: new study tests groovy therapy
Symptom relief CompletedThis study tested whether group dance classes can improve balance and motivation in breast cancer survivors who have nerve damage from chemotherapy. Fifty-two survivors participated in either dance-based exercise or standard exercise for several weeks. The goal was to see if danc…
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Jun 26, 2026 17:12 UTC
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New nerve pain drug shows promise in Year-Long trial
Symptom relief CompletedThis study tested the long-term safety and effectiveness of HSK16149, a drug for nerve pain, in 301 Chinese patients over 52 weeks. All participants had previously completed a shorter trial and tolerated the drug. Researchers tracked side effects and pain scores to see if the dru…
Phase 3 • Sponsor: Haisco Pharmaceutical Group Co., Ltd. • Aim: Symptom relief
Last updated Jun 26, 2026 13:43 UTC