Patellofemoral pain syndrome
MONDO:0006894A syndrome characterized by retropatellar or peripatellar pain resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) chondromalacia patellae, the latter describing a pathological condition of the cartilage and not a syndrome.
90 clinical trials for this condition and its sub-types, 79 tagged with Patellofemoral pain syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
-
Taping techniques face off in knee pain trial
Symptom relief Recruiting nowPatellofemoral pain syndrome causes knee pain during activities like squatting or climbing stairs. This trial compares two taping methods, McConnell and Kinesio, each combined with a four-week hip and knee strengthening program. Thirty-four adults aged 26 to 44 with this knee pai…
Sponsor: Foundation University Islamabad • Aim: Symptom relief
Last updated Sep 21, 2026 16:00 UTC
-
Which knee exercise works best for anterior knee pain? new study aims to find out
Symptom relief Recruiting nowThis study compares three types of knee-strengthening exercises (isometric, isotonic, and eccentric) in 90 adults aged 18-40 with patellofemoral pain syndrome. Participants will do their assigned exercises three times a week for 8 weeks, alongside standard physiotherapy. Research…
Sponsor: Firat University • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
-
App-based rehab may match in-person therapy for athletes with knee pain
Symptom relief Recruiting nowThis study compares a mobile app-based rehabilitation program to traditional in-person physiotherapy for recreational athletes aged 18–35 with patellofemoral pain syndrome (pain around the kneecap). Both groups follow the same exercise plan for four weeks, but one group does it r…
Sponsor: University of Faisalabad • Aim: Symptom relief
Last updated Jul 11, 2026 00:00 UTC
-
Which tape wins for knee pain? new study pits kinesio vs McConnell
Symptom relief Recruiting nowThis study compares Kinesio taping and McConnell taping in people aged 18–50 with patellofemoral pain syndrome (front knee pain). Participants will receive one of the taping methods plus a 6-week exercise program, or just exercise alone. Researchers will measure muscle activation…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 28, 2026 00:00 UTC
-
Can gentle exercise with a cuff beat knee pain in athletes?
Symptom relief Recruiting nowThis study compares two exercise methods that use a cuff to partly restrict blood flow to the leg: resistance training with light weights versus stationary cycling. Both aim to reduce pain and improve strength in athletes with patellofemoral pain syndrome. Forty-eight athletes ag…
Sponsor: Ibadat International University, Islamabad • Aim: Symptom relief
Last updated Jun 28, 2026 00:00 UTC
-
Knee pain relief showdown: muscle release or tape?
Symptom relief Recruiting nowThis study compares two treatments for patellofemoral pain syndrome (knee pain): releasing the popliteus muscle versus applying kinesio tape. About 48 adults aged 18-30 with at least 3 months of knee pain will be enrolled. The goal is to see which approach better reduces pain, im…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 12:39 UTC
-
New study aims to ease knee pain for soldiers with smarter PT
Symptom relief Recruiting nowThis study looks at whether following specific clinical guidelines for treating patellofemoral pain (a common knee problem) works better than usual physical therapy. About 440 active-duty military members will take part. Researchers will compare knee function, pain levels, and co…
Sponsor: Sara Gorczynski, PT, DPT • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
-
Vibration therapy tested for Post-ACL knee pain relief
Symptom relief Recruiting nowThis study looks at whether whole-body vibration therapy can reduce knee pain in people who still have pain after ACL reconstruction surgery. About 50 adults aged 18 to 60 with ongoing kneecap pain will use a vibrating platform for 8 weeks. The goal is to see if this simple train…
Sponsor: Chinese University of Hong Kong • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
-
Can tiny needles tame your knee pain?
Symptom relief Recruiting nowThis study looks at whether dry needling can ease knee pain and improve leg strength and function in people with patellofemoral pain syndrome (pain around the kneecap). Researchers will give dry needling treatments to 120 adults aged 18 to 40 and measure changes in pain and movem…
Sponsor: Ohio State University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
-
Hands-On nerve release could ease common knee pain
Symptom relief Recruiting nowThis study tests a manual therapy technique called saphenous nerve release to see if it can reduce pain, improve balance, and restore function in people with patellofemoral pain syndrome (a common cause of front knee pain). The trial will include 36 adults aged 18 to 35 with pers…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
-
New imaging study aims to unlock secrets of human movement
Knowledge-focused Recruiting nowThis study uses MRI and ultrasound to watch how muscles, tendons, and bones work together when you move. Researchers hope to learn what normal and injured movement looks like, which could lead to better ways to diagnose and treat problems like knee pain. Healthy volunteers and pe…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
-
Tight ankles worsen knee pain? new study investigates
Knowledge-focused Recruiting nowThis study looks at how limited ankle movement affects a single-leg squat in people with long-term knee pain (patellofemoral pain). Researchers will measure ankle flexibility and pain during daily activities. The goal is to better understand the link between ankle tightness and k…
Sponsor: Loma Linda University • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
-
New knee scan study aims to unlock secrets of 'Runner's Knee' and arthritis
Knowledge-focused Recruiting nowThis study is looking at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will take 3D CT scans of the knee while people stand (weight-bearing) to see the joint in a natural position. They hope to find links between specific bone measurements and …
Sponsor: University of Kansas Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
850 knee patients tracked to uncover why MPFL surgery sometimes fails
Knowledge-focused Recruiting nowThis study follows 850 people aged 10–35 who are having surgery for a kneecap that keeps dislocating. Researchers want to find out what factors increase the risk of the kneecap dislocating again after surgery. Participants will fill out surveys about their knee function and activ…
Sponsor: Hospital for Special Surgery, New York • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
-
Online lessons may ease knee pain while waiting for treatment
Knowledge-focused Recruiting nowThis study tests whether an online education tool is a practical option for people with patellofemoral pain (knee pain) who are waiting for physiotherapy. Researchers will recruit 40 adults aged 18-44 and see if they can complete the online modules and questionnaires. The goal is…
Sponsor: East Suffolk and North Essex NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC