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Which knee exercise works best for anterior knee pain? new study aims to find out

NCT ID NCT07562425

Symptom relief Sponsor: Firat University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study compares three types of knee-strengthening exercises (isometric, isotonic, and eccentric) in 90 adults aged 18-40 with patellofemoral pain syndrome. Participants will do their assigned exercises three times a week for 8 weeks, alongside standard physiotherapy. Researchers will measure changes in pain, function, and muscle structure using ultrasound and performance tests.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise (isometric, isotonic, or eccentric vastus medialis oblique strengthening)
What this could lead to
If successful, this study could show which type of knee exercise best reduces pain and improves daily function for people with anterior knee pain.
What could go wrong
This is a small, early-stage trial with only 90 participants. Results may not apply to everyone with knee pain, and exercise benefits can vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 18 and 40 years * Clinically diagnosed with patellofemoral pain syndrome * Presence of anterior knee pain for at least 3 months * Pain during activities such as stair climbing, squatting, running, or prolonged sitting * Pain intensity of at least 3/10 on the Visual Analog Scale (VAS) * Willingness to participate and provide written informed consent Exclusion Criteria: * History of knee trauma or surgery * Meniscal injury, ligament injury, or knee instability * Advanced osteoarthritis * Neurological disorders * Rheumatologic diseases * Participation in a structured knee rehabilitation program within the last 6 months * Pregnancy

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Conditions

The condition(s) this trial relates to.

patellofemoral pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior knee pain Patellofemoral pain syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Firat University

    RECRUITING

    Elâzığ, MErkez, 23200, Turkey (Türkiye)

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