App-Based therapy aims to tackle knee pain without pills
NCT ID NCT07769593
First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time
Summary
This study tests whether a digital therapeutic called MORA Cure can reduce knee pain in adults over 50 with knee osteoarthritis and anterior knee pain. Participants use a mobile app for 8 weeks that provides personalized exercises and cognitive behavioral therapy content. The app also tracks symptoms and movement to adjust the program. The goal is to see if this app-based approach improves pain and function, offering a potential non-drug option for managing osteoarthritis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MORA Cure, a digital therapeutic app providing personalized rehabilitation exercises and cognitive behavioral therapy content
- What this could lead to
- If effective, MORA Cure could offer a non-drug, app-based way to reduce knee pain and improve function in people with osteoarthritis, potentially delaying or avoiding surgery.
- What could go wrong
- This is a small pilot study without a control group, so results may not be conclusive. The app's benefits could be modest, and not everyone may find it easy to use or adhere to the exercise regimen.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 44 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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51 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults older than 50 years. 2. Kellgren-Lawrence grade 1 or higher on weight-bearing plain radiographs of the study knee. 3. Osteoarthritis-related pain in the study knee for at least 3 months. 4. Anterior knee pain in the study knee involving the peripatellar, anterior patellar, or retropatellar region, with clear provocation or worsening of anterior knee pain during at least one patellofemoral joint-loading activity: stair ascent or descent, squatting, or rising from a chair. 5. If medial, lateral, or posterior knee pain is also present, the participant is able to distinguish and separately report anterior knee pain. 6. Voluntary written informed consent before study participation. Exclusion Criteria: 1. Acute injury of the study knee within the previous 3 months, including fracture, ligament tear, or meniscal tear requiring surgical treatment or immobilization. 2. Injection therapy to the study knee within the previous 3 months. 3. Current use of opioid analgesics for pain control. 4. Does not own a smartphone or is unable to use the mobile application. 5. Current participation in another clinical trial or planned participation in another clinical trial during this study. 6. Diagnosed active inflammatory arthritis, including rheumatoid arthritis, psoriatic arthritis, or reactive arthritis. 7. Acute attack of gout or pseudogout in the study knee within the previous 3 months. 8. Previous total knee arthroplasty, corrective osteotomy, or other major surgery affecting knee alignment or joint structure in the study knee. 9. Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHA Bundang Medical Center
Seongnam-si, Gyeonggi-do, 13496, South Korea
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SMG-SNU Boramae Medical Center
Dongjak, Seoul, 07061, South Korea
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