Oral cavity cancer

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests whether avoiding radiation to the surgical flap (the tissue used to rebuild the mouth after cancer removal) is as effective as standard radiation that treats the whole area. About 348 adults with oral cavity cancer who had reconstructive surgery will be randomly …

This study is testing whether taking three oral chemotherapy drugs together is safe and practical for patients with head and neck cancer that has returned or spread. The trial focuses on people living in rural Midwest areas, making it easier for them to participate from home. The…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink or control advanced head and neck cancer that has grown after initial therapy. About 40 adults whose cancer has spread or returned will receive the combination. The goal is to see how ma…

This trial tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery. The program provides education, social support, and better coordination among doctors. Researchers will compare it to usual care in 532 adults w…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This pilot study is testing whether people with early-stage oral or throat cancer (T1-N0 or T2-N0) can safely have their tumor removed as an outpatient, going home the same day. The procedure also includes a sentinel lymph node biopsy to check for cancer spread. Researchers will …

This study tests a new surgical technique using a thin skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if it causes fewer problems at the donor site compared to standard flaps. Forty adults with head and neck cancer will be fo…

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This study tests whether specially adapted beauty sessions (onco-esthetics) can help people with head and neck cancer feel better about their changed appearance after treatment. Fifty-five patients will receive three sessions, and researchers will measure how their self-image cha…

This study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…

This study aims to see if a custom-made tumor culture system can predict how oral cavity cancer responds to the immunotherapy drug pembrolizumab before surgery. Twenty participants will provide a biopsy, receive pembrolizumab as standard care, and then have their tumor analyzed. …

This study compares two ways to rebuild the jaw after oral cancer surgery: standard free-hand surgery versus using 3D-printed guides made from virtual planning. About 420 adults needing jaw reconstruction will be randomly assigned to one method. The main goal is to see which appr…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study uses repeated MRI scans after radiation therapy to see if they can predict normal tissue damage, like bone death (osteoradionecrosis), in patients with oral cavity or skull base tumors. Researchers will track changes in imaging over time and link them to radiation dose…

This study looks at how cancer and its treatments change a person's sense of taste and smell, and how that affects their eating and nutrition. Researchers will follow 306 people newly diagnosed with cancer of the mouth, throat, colon, or liver. They will use questionnaires, taste…

This study observes 200 adults with head and neck cancer who need facial reconstruction using a free bone flap after surgery. Researchers will track their medical visits, treatments, and costs over time using national health data. The goal is to describe typical care pathways and…

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…