Newborn respiratory distress syndrome

This study looks at a new method for removing breathing tubes from very premature babies (born before 32 weeks). Normally, doctors remove the tube first and then put on a gentle breathing mask. The new method puts the mask on first, before removing the tube. Researchers want to s…

This trial tests whether giving surfactant through a small tube while babies breathe with high-flow nasal cannula support can reduce the need for invasive ventilation. The study includes infants born 2-6 weeks early who have respiratory distress. Researchers will compare outcomes…

This study compares delayed cord clamping (waiting at least 30 seconds after birth) with immediate clamping in preterm infants born between 32 and 37 weeks. The goal is to see if the extra time improves early health outcomes such as breathing, anemia risk, and survival. Researche…

This study tests if giving surfactant (a natural substance that helps lungs stay open) through a less invasive method helps premature babies with breathing problems survive. About 1,500 babies weighing 1.5 to 4.4 pounds will receive this treatment in African hospitals that lack b…

This study tests whether giving pregnant people at risk of preterm birth half the usual dose of a steroid (Celestone) works as well as the full dose to prevent serious health problems in their babies. About 3,250 participants will receive either one or two doses after an initial …

This study tests whether a special breathing machine called high-frequency oscillation ventilation (HFOV) works better than standard mechanical ventilation for very premature babies (born at 24 to 31 weeks) who have acute respiratory distress syndrome (ARDS). The goal is to see i…

This study tests whether a lung ultrasound score can help doctors decide faster when to give surfactant—a medicine that helps babies' lungs work—to preterm infants with respiratory distress. Researchers will include 100 babies born between 27 and 34 weeks who need breathing suppo…

This study tests whether using a lung ultrasound score can help doctors decide when to give surfactant therapy to premature infants with respiratory distress syndrome. Surfactant is a substance that helps babies' lungs stay open, but giving it too late can reduce its benefit. The…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications in infants born at 29 weeks o…

This study tests whether using a video camera (video laryngoscopy) helps doctors give surfactant—a medicine that helps lungs work—to very premature babies more successfully on the first try compared to the standard direct-look method. About 100 babies born at 28 weeks or earlier …

This study looks at whether giving surfactant (a lung treatment) over 1 minute or 5 minutes helps very premature babies (under 28 weeks) stay more stable. The goal is to see which speed leads to better oxygen levels in the blood and brain. 76 babies will take part, and the result…

This study tests whether briefly increasing the air pressure from a CPAP machine before giving surfactant therapy helps preterm babies' lungs work better. Surfactant is a natural substance that helps immature lungs stay open, and it's often given through a thin tube. The trial wi…

This study watches 300 premature babies who need surfactant—a natural substance that helps their lungs stay open. Doctors will use different methods to give the medicine, like a thin tube or a mask, and track which babies need a breathing machine or more medicine within 72 hours.…

This study tracks lung ultrasound images over time in preterm babies born before 32 weeks who need surfactant for breathing problems. Researchers want to see if the way surfactant is given changes how the lungs look on ultrasound. About 68 babies will take part to help doctors le…

This study looks at preterm infants who need breathing support from a machine called nasal CPAP. Researchers want to find out how much oxygen actually reaches the baby's lungs by placing a small tube in the back of the mouth and using soft bands around the chest to measure lung e…

This study compares two types of CPAP machines that help premature babies breathe. One delivers a constant flow of air, the other a variable flow. Researchers will measure the babies' diaphragm activity to see if constant flow works just as well. The study involves 20 infants bor…

This study looks at whether a lung ultrasound done shortly after birth can predict which late preterm babies (born 34–36 weeks) will have breathing problems in the first two days of life. Researchers will compare three different ultrasound scoring methods. The goal is to help doc…

This study looks at whether using a video laryngoscope (a tool with a camera) helps doctors place a breathing tube in newborns more safely than the standard direct laryngoscope. About 840 babies across multiple hospitals will be included. The goal is to see if video laryngoscopy …

This study compares lung ultrasound to standard chest X-rays in very preterm infants (born before 32 weeks) who need breathing support. The goal is to see if ultrasound can safely reduce the number of X-rays, lowering radiation exposure. About 180 babies will be randomly assigned…

This study looks at two methods of giving surfactant (a medicine that helps lungs work) to premature babies with breathing problems. One method uses a thin tube without a breathing tube, and the other uses a standard breathing tube. Researchers will use lung ultrasound to see whi…

This study looks at whether analyzing stomach fluid from newborns can predict if they will need breathing support for more than 6 hours after birth. Researchers will enroll 500 babies born at 32 weeks or later in a lower-level NICU. The goal is to see if a new algorithm can accur…