Musculoskeletal system disorder
MONDO:0002081A disease involving the musculoskeletal system.
Also known as: disease of musculoskeletal system, disease or disorder of musculoskeletal system, disorder of musculoskeletal system, musculoskeletal disease, musculoskeletal system disease, musculoskeletal system disease or disorder, musculoskeletal system disorder, musculoskeletal disorder
12041 clinical trials for this condition and its sub-types, 220 tagged with Musculoskeletal system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Musculoskeletal system disorder
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Skeletal system disorder 4 trials · 9,737 incl. sub-types
48 sub-types
- Bone disorder 53 trials · 6,305 incl. sub-types Sub-types →
- Arthropathy 139 trials · 3,208 incl. sub-types Sub-types →
- Bone marrow disorder 18 trials · 1,763 incl. sub-types Sub-types →
- Vertebral column disorder 82 trials · 1,243 incl. sub-types Sub-types →
- Periodontal disorder 303 trials · 982 incl. sub-types Sub-types →
- Tooth disorder 38 trials · 892 incl. sub-types Sub-types →
- Flatfoot 60 trials
- Patellar tendinitis 22 trials
- Marfan syndrome 21 trials Sub-types →
- Fibrodysplasia ossificans progressiva 10 trials
- Polydactyly 2 trials · 9 incl. sub-types Sub-types →
- Syndactyly 3 trials · 9 incl. sub-types Sub-types →
- Skeletal ligament disorder 0 trials · 7 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Coffin-Siris syndrome 1 trial Sub-types →
- Cartilage-hair hypoplasia 1 trial Sub-types →
- Cherubism 1 trial Sub-types →
- Ochronosis disorder 1 trial Sub-types →
- Ossification of the posterior longitudinal ligament of the spine 1 trial
- Primary basilar invagination 1 trial
- Short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome 1 trial
- Symphalangism 0 trials · 1 incl. sub-types Sub-types →
- Al-Gazali syndrome 0 trials
- Brachymorphism-onychodysplasia-dysphalangism syndrome 0 trials
- Buschke-Ollendorff syndrome 0 trials
- Rienhoff syndrome 0 trials
- Teebi-Shaltout syndrome 0 trials
- Anterior cranial fossa meningioma 0 trials Sub-types →
- Brachydactyly 0 trials Sub-types →
- Brachydactyly-syndactyly syndrome 0 trials
- Brachydactyly-syndactyly-oligodactyly syndrome 0 trials
- Cartilage cancer 0 trials
- Cartilage development disorder 0 trials
- Cranial nodular fasciitis 0 trials
- Endocrine-cerebro-osteodysplasia syndrome 0 trials
- Laryngeal cartilage cancer 0 trials
- Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria 0 trials
- Metaphyseal undermodeling, spondylar dysplasia, and overgrowth 0 trials
- Microcephaly-brachydactyly-kyphoscoliosis syndrome 0 trials
- Middle cranial fossa meningioma 0 trials Sub-types →
- Multiple congenital anomalies-hypotonia-seizures syndrome 3 0 trials
- Necrosis of ear ossicle 0 trials
- Posterior cranial fossa meningioma 0 trials Sub-types →
- Scalp defects-postaxial polydactyly syndrome 0 trials
- Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis 0 trials
- Skeletal tuberculosis 0 trials Sub-types →
- Sternal neoplasm 0 trials Sub-types →
- Temtamy preaxial brachydactyly syndrome 0 trials
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Muscle tissue disorder 58 trials · 2,427 incl. sub-types
13 sub-types
- Skeletal muscle disorder 11 trials · 1,366 incl. sub-types Sub-types →
- Cardiomyopathy 155 trials · 823 incl. sub-types Sub-types →
- Myomatous neoplasm 1 trial · 188 incl. sub-types Sub-types →
- Myalgic encephalomeyelitis/chronic fatigue syndrome 75 trials
- Conduction system disorder 8 trials · 46 incl. sub-types Sub-types →
- Myostatin-related muscle hypertrophy 10 trials
- Atrophic muscular disease 7 trials
- Distal arthrogryposis 0 trials · 3 incl. sub-types Sub-types →
- Kocher-debre-Semelaigne syndrome 0 trials
- Caveolinopathy 0 trials Sub-types →
- Septal myocardial infarction 0 trials
- Striated muscle rhabdoid tumor 0 trials
- Tonsillar pillar cancer 0 trials
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Musculoskeletal system cancer 2 trials · 1,970 incl. sub-types
11 sub-types
- Bone cancer 79 trials · 1,923 incl. sub-types Sub-types →
- Muscle cancer 0 trials · 72 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Synovium cancer 1 trial · 2 incl. sub-types Sub-types →
- Ameloblastic carcinoma 0 trials
- Broad ligament malignant neoplasm 0 trials Sub-types →
- Cartilage cancer 0 trials
- Laryngeal cartilage cancer 0 trials
- Round ligament malignant neoplasm 0 trials
- Tonsillar pillar cancer 0 trials
- Uterine ligament cancer 0 trials Sub-types →
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Autoimmune disorder of musculoskeletal system 0 trials · 797 incl. sub-types
3 sub-types
- Rheumatoid arthritis 578 trials · 797 incl. sub-types Sub-types →
- Autoimmune cardiomyopathy 0 trials Sub-types →
- Neonatal dermatomyositis 0 trials
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Musculoskeletal system benign neoplasm 0 trials · 224 incl. sub-types
8 sub-types
- Benign muscle neoplasm 4 trials · 118 incl. sub-types Sub-types →
- Benign connective and soft tissue neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Chondroma 4 trials Sub-types →
- Ameloblastoma 2 trials Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Benign neoplasm of sternum 0 trials
- Benign skeletal muscle neoplasm 0 trials
- Benign uterine ligament neoplasm 0 trials
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Disease of the tendon 126 trials · 192 incl. sub-types
3 sub-types
- Tendinitis 24 trials · 77 incl. sub-types Sub-types →
- Tendon sheath disorder 0 trials · 30 incl. sub-types Sub-types →
- Tendinosis 17 trials
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Synovium disorder 0 trials · 149 incl. sub-types
4 sub-types
- Synovial bursa disorder 0 trials · 119 incl. sub-types Sub-types →
- Synovium neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Synovitis 15 trials Sub-types →
- Synovial plica syndrome 1 trial
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Fasciitis 7 trials · 97 incl. sub-types
6 sub-types
- Plantar fasciitis 85 trials
- Necrotizing fasciitis 7 trials
- Eosinophilic fasciitis 1 trial
- Ischemic fasciitis 0 trials
- Nodular fasciitis 0 trials Sub-types →
- Proliferative fasciitis 0 trials
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Ligament disorder 8 trials · 15 incl. sub-types
4 sub-types
- Skeletal ligament disorder 0 trials · 7 incl. sub-types Sub-types →
- Disorder of uterine broad ligament 0 trials Sub-types →
- Round ligament malignant neoplasm 0 trials
- Uterine ligament neoplasm 0 trials Sub-types →
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Klippel-Feil syndrome 14 trials
6 sub-types
- Calabro syndrome 0 trials
- Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome 0 trials
- Klippel-Feil syndrome 1, autosomal dominant 0 trials
- Klippel-Feil syndrome 2, autosomal recessive 0 trials
- Klippel-Feil syndrome 3, autosomal dominant 0 trials
- Wildervanck syndrome 0 trials
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CINCA syndrome 4 trials
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Enthesopathy 2 trials · 4 incl. sub-types
5 sub-types
- Enthesitis 2 trials
- Fibular collateral ligament bursitis 0 trials
- Olecranon bursitis 0 trials
- Pes anserinus tendinitis or bursitis 0 trials
- Tibial collateral ligament bursitis 0 trials
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Ramon syndrome 0 trials
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Short stature, Dauber-Argente type 0 trials
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Upington disease 0 trials
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Auriculoosteodysplasia 0 trials
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Short stature, Brussels type 0 trials
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Synovial chondromatosis 0 trials
Most studied deeper sub-types
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Video physiotherapy: a greener, cheaper way to treat pain?
Disease control Not yet recruitingThis trial tests whether a first physiotherapy appointment done over video works as well as a traditional in-person visit for people with muscle, bone, or joint pain. Participants will be randomly assigned to either a video or in-person consultation and followed for up to two yea…
Sponsor: Vastra Gotaland Region • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Testosterone may rebuild strength after spinal cord injury — trial puts it to the test
Disease control Not yet recruitingThis trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…
Phase 2/3 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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Workplace pain education may cut sick days by teaching employees and managers to talk about pain
Disease control Not yet recruitingThis study tests whether a workplace program that teaches employees and managers about pain and how to communicate about it can reduce pain-related sick leave. The program includes a digital education session and a workplace needs assessment. Researchers will track sick days, pai…
Sponsor: National Research Centre for the Working Environment, Denmark • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Hospital cleaners get a posture makeover to fight pain
Disease control Not yet recruitingThis study tests a posture protection program for 60 hospital cleaners to see if it reduces muscle and bone pain. The program includes training on safe lifting, body mechanics, and posture awareness, plus reminders via posters and messages. Researchers will measure pain levels an…
Sponsor: Akdeniz University • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Ultrasound may reveal hidden bone damage in blood cancers
Diagnosis Not yet recruitingThis study tests whether musculoskeletal ultrasound can reliably detect bone, joint, and soft-tissue problems in adults with blood cancers like leukemia, lymphoma, and multiple myeloma. Participants with symptoms such as bone pain, joint swelling, or muscle pain will receive a de…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Aug 27, 2026 00:00 UTC
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Can biofeedback make patient handling safer for nurses?
Prevention Not yet recruitingAssistant nurses often develop back, neck, and shoulder pain from frequent patient handling. This trial tests whether workplace ergonomic training can reduce that pain, and whether adding biofeedback for six weeks provides extra benefit. Sixty female assistant nurses with musculo…
Sponsor: Linkoeping University • Aim: Prevention
Last updated Sep 12, 2026 00:00 UTC
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New pill aims to shield stomachs from common painkiller damage
Prevention Not yet recruitingThis study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…
Phase 4 • Sponsor: Daewoong Pharmaceutical Co. LTD. • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Cash rewards and coaching put to the test for Post-Surgery walking
Symptom relief Not yet recruitingMany people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…
Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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3D-Printed hand braces could be cheaper and just as effective
Symptom relief Not yet recruitingThis study compares 3D-printed hand orthoses (braces) to traditional custom-made ones in 100 adults with chronic hand conditions from nerve, muscle, or bone issues. The goal is to see if the 3D-printed versions work just as well for daily activities, are more satisfying, and cost…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Warehouse workers test wearable robot suits to prevent back pain
Symptom relief Not yet recruitingThis study tests whether wearing a back-support exoskeleton during daily warehouse work can reduce back pain, sick leave, and discomfort. About 90 full-time workers in a Danish warehouse will either use the device or continue normal work for 18 months. Researchers will track pain…
Sponsor: Aalborg University • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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New program aims to help breast cancer patients stick with treatment by easing pain
Symptom relief Not yet recruitingThis study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…
Sponsor: Addis Ababa University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Phone app may boost exercise for aching joints
Symptom relief Not yet recruitingThis study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…
Sponsor: National Yang Ming Chiao Tung University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Can VR games ease stubborn shoulder pain?
Symptom relief Not yet recruitingThis study tests four different virtual reality (VR) exercises in 30 adults who have had rotator cuff-related shoulder pain for at least 6 months. Participants will do weekly VR sessions for four weeks and complete questionnaires about their arm function, pain, and fear of moveme…
Sponsor: Laval University • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Volleyball players: can a simple band boost your shoulder mobility instantly?
Symptom relief Not yet recruitingThis study tests whether using a floss band or a hands-on movement technique can immediately improve shoulder mobility in volleyball athletes. Thirty-six amateur or professional players will be randomly assigned to one of the two methods. Their shoulder range of motion, movement …
Sponsor: Federal University of Paraíba • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Could nerve zaps ease leg pain? new trial investigates
Symptom relief Not yet recruitingThis study tests whether adding a nerve stimulation treatment to standard exercise and stretching can improve pain, movement, and quality of life in people with lower limb muscle or joint problems. Sixty-four adults who have not yet had physical therapy will be randomly assigned …
Sponsor: University of Malaga • Aim: Symptom relief
Last updated Jun 26, 2026 16:46 UTC
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Could a zap to the nerves ease stubborn arm pain?
Symptom relief Not yet recruitingThis study tests whether adding nerve stimulation (neuromodulation) to standard exercise and stretching can improve pain, movement, and quality of life in people with upper limb musculoskeletal problems. About 120 working-age adults who haven't had physical therapy will be split …
Sponsor: University of Malaga • Aim: Symptom relief
Last updated Jun 26, 2026 16:26 UTC
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Can a catalan questionnaire accurately measure arm, shoulder, and hand disability?
Knowledge-focused Not yet recruitingThis study aims to translate and validate a Catalan version of the QuickDASH questionnaire, a widely used tool for measuring upper extremity disability. The research involves Catalan-speaking adults with upper limb disorders and follows a two-phase process: translation and cultur…
Sponsor: Corporacion Parc Tauli • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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New digital tool aims to speed up return to work for those with muscle pain
Knowledge-focused Not yet recruitingThis study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 15, 2026 00:00 UTC
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Do special ed teachers face more burnout? study investigates
Knowledge-focused Not yet recruitingThis study compares work-related health issues like burnout, stress, and muscle pain between general education teachers and special education teachers. About 200 teachers will fill out questionnaires about their well-being and job satisfaction. The goal is to understand if specia…
Sponsor: Lokman Hekim University • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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New urdu tool could help millions with muscle and joint pain
Knowledge-focused Not yet recruitingThis study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…
Sponsor: Riphah International University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Can Sauna-Like heat help chronic pain? new study investigates
Knowledge-focused Not yet recruitingThis study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…
Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Leftover tendon tissue could unlock secrets of injury and disease
Knowledge-focused Not yet recruitingThis study aims to learn more about how tendons work and why they get sick. Researchers will collect small pieces of tendon tissue that are normally thrown away during planned surgeries in adults. Participants do not need to do anything extra—just give permission to use the lefto…
Sponsor: Queen Mary University of London • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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AI vs. doctor: which note do patients trust more?
Knowledge-focused Not yet recruitingThis study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …
Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Can digital tools predict which physical therapists get hurt on the job?
Knowledge-focused Not yet recruitingThis study will use digital motion-capture software to compare how often female and male physical therapists in Egypt are at risk for work-related muscle and joint injuries. Researchers will record therapists' movements with an iPhone and analyze their posture and range of motion…
Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Why do patients quit their tendon exercises? new study aims to find out
Knowledge-focused Not yet recruitingAchilles tendinopathy causes pain and stiffness in the ankle tendon, making daily activities hard. The main treatment is a program of specific exercises, but many people struggle to keep them up. This study will interview up to 30 adults who have had NHS physiotherapy for this co…
Sponsor: East Lancashire Hospitals NHS Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Could a simple survey predict workplace pain?
Knowledge-focused Not yet recruitingThis study aims to develop and test a new questionnaire to screen for work-related musculoskeletal disorders (WMSDs) — aches and pains caused by job tasks. Researchers will ask 250 biopharmaceutical workers to fill out the new tool along with standard surveys. The goal is to see …
Sponsor: Sahmyook University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Dentists' neck pain under the microscope: new study aims to find solutions
Knowledge-focused Not yet recruitingThis study looks at neck pain and related problems in Turkish endodontists (dentists who do root canals). About 120 endodontists will answer questions about their work and neck pain, and have physical tests like neck movement and strength. The goal is to find what causes neck pai…
Sponsor: Atlas University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Cycle secrets: study links period phases to muscle strength
Knowledge-focused Not yet recruitingThis study looks at how different phases of the menstrual cycle relate to muscle strength and physical performance in healthy, active women aged 18 to 35. Participants will track their cycle with a phone app and attend three lab visits for strength tests and body measurements. Th…
Sponsor: Charles University, Czech Republic • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Sitting too much? study links desk jobs to poor posture, sleep, and mood
Knowledge-focused Not yet recruitingThis study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…
Sponsor: Istanbul Aydın University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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New telemedicine approach aims to catch decline in fragile patients early
Knowledge-focused Not yet recruitingThis observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…
Sponsor: Azienda Sanitaria Locale CN2 Alba-Bra • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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100,000 volunteers sought for landmark ageing study
Knowledge-focused Not yet recruitingHealthspan Connect is a new research programme aiming to understand what helps people stay healthy as they age. It will recruit 100,000 participants aged 12 and older across the UK, using digital tools and home-based sample collection. The study will explore how lifestyle, enviro…
Sponsor: King's College London • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Study explores how conversations shape patient choices on x-rays and MRIs
Knowledge-focused Not yet recruitingThis study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…
Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:22 UTC