Mood disorder

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of …

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Re…

This study tests whether personalized smartphone notifications can improve mood, sleep, and physical activity in medical interns. Participants receive mood, activity, or sleep tips through a mobile app, with the content chosen by a learning algorithm. The goal is to see if these …

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This pilot study tests whether a mobile neurofeedback device (MUSE 2) can help new mothers who have experienced trauma feel better and reduce stress. Forty mothers with PTSD symptoms will use the headband at home for 12 weeks, receiving audio feedback to train their brains to sta…

This study looks at whether a brain-training technique called neurofeedback can help new mothers who have experienced trauma feel better and manage their emotions. Twenty postpartum women with trauma-related symptoms will try the training alongside their usual care. The goal is t…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests a short, enhanced cognitive behavioral therapy (E-BCBT) for people hospitalized after a suicide crisis. 30 participants will either receive 5 therapy sessions during their stay or standard care. The goal is to see if this therapy reduces suicide attempts and suic…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study looks at whether adding a structured therapy journal to standard cognitive behavioral therapy (CBT) helps people with mental health conditions like depression, anxiety, or eating disorders feel better faster. About 80 adults in outpatient therapy will be randomly assig…

This study tests whether a breathing training program can improve sleep in people whose insomnia is linked to anxiety or depression. Researchers will monitor sleep quality and heart activity in 188 adults. The goal is to find a simple, drug-free way to ease sleep problems and und…

This study tests whether a 12-week supervised group exercise program with music can boost emotional well-being in physically inactive women aged 35-60 who feel stressed or down. One hundred women will be randomly assigned to either the exercise group or a waitlist. Researchers wi…

This study aimed to see if putting up fake windows that show outdoor scenes could improve the mood of teachers working in classrooms without real windows. It was planned for teachers at one school in New York, but the study was withdrawn before any teachers joined. No results are…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study looks at whether actively caring for plants (like watering and pruning) can lower stress, improve mood, and boost academic motivation in college students. About 87 students will either care for plants on campus, at home, or not engage with plants at all. Over a 16-week…

This study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in people hospitalized for depression. Fifty adults with major depression and active suicidal ideas will receive either nitrous oxide or a placebo gas, plus their usual treatment. …

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…

The SHAKTI study is a 5-year observational project that will follow 6,000 people of Asian or Pacific Islander descent, aged 10 and older, with depression or related mood disorders. Researchers will collect a wide range of data—including lifestyle, clinical history, blood and stoo…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study explores whether attending free community events in renovated neighborhood parks can improve sleep, stress, mood, and overall well-being in adults aged 18 and older who live nearby. Participants wear a smart ring to track sleep and complete surveys over about six month…

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study aimed to track brain activity in people with depression over time and see how a single dose of ketamine might change it. It was withdrawn before any participants were enrolled, so no results are available.

This study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…

This study is testing whether data from smartphones and wearable devices can predict when a person with depression or bipolar disorder might have another episode. Over 12 months, 540 participants will wear a Fitbit, log daily moods, and complete five check-ins. Researchers will u…