Metabolic disease
MONDO:0005066A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.
Also known as: disorder of metabolic process, metabolic disease, metabolic disorder, metabolic process disease, disease of metabolism
7349 clinical trials for this condition and its sub-types, 245 tagged with Metabolic disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Metabolic disease
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Glucose metabolism disease 62 trials · 4,125 incl. sub-types
9 sub-types
- Diabetes mellitus 1,271 trials · 3,811 incl. sub-types Sub-types →
- Prediabetes syndrome 443 trials
- Glucose intolerance 149 trials
- Hyperglycemia 132 trials
- Hypoglycemia 119 trials
- Hyperinsulinism 34 trials · 42 incl. sub-types Sub-types →
- Disorder of gluconeogenesis 0 trials · 1 incl. sub-types Sub-types →
- Glyceraldehyde-3-phosphate dehydrogenase deficiency 0 trials
- Triosephosphate isomerase deficiency 0 trials
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Inborn errors of metabolism 48 trials · 2,228 incl. sub-types
93 sub-types
- Inherited lipid metabolism disorder 201 trials · 644 incl. sub-types Sub-types →
- Inborn carbohydrate metabolic disorder 3 trials · 369 incl. sub-types Sub-types →
- Abdominal obesity-metabolic syndrome 301 trials · 357 incl. sub-types Sub-types →
- Lysosomal storage disease 37 trials · 302 incl. sub-types Sub-types →
- Inborn disorder of energy metabolism 2 trials · 235 incl. sub-types Sub-types →
- Inborn disorder of amino acid and other organic acid metabolism 0 trials · 225 incl. sub-types Sub-types →
- Waldenstrom macroglobulinemia 136 trials Sub-types →
- DNA repair disease 13 trials · 105 incl. sub-types Sub-types →
- Hereditary amyloidosis 19 trials · 79 incl. sub-types Sub-types →
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Mucopolysaccharidosis or mucopolysaccharidosis-like disorder 0 trials · 61 incl. sub-types Sub-types →
- Inborn metal metabolism disorder 1 trial · 60 incl. sub-types Sub-types →
- Disorder of metabolite absorption and transport 0 trials · 59 incl. sub-types Sub-types →
- Inborn disorder of purine or pyrimidine metabolism 1 trial · 50 incl. sub-types Sub-types →
- Plasma protein metabolism disease 0 trials · 47 incl. sub-types Sub-types →
- Peroxisomal disease 2 trials · 38 incl. sub-types Sub-types →
- Congenital disorder of glycosylation 7 trials · 36 incl. sub-types Sub-types →
- Monogenic diabetes 9 trials · 24 incl. sub-types Sub-types →
- Glycoprotein metabolism disease 1 trial · 23 incl. sub-types Sub-types →
- Disorder of lysosomal-related organelles 0 trials · 17 incl. sub-types Sub-types →
- Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Familial hypoparathyroidism 0 trials · 10 incl. sub-types Sub-types →
- Inborn disorder of biogenic amine metabolism and transport 0 trials · 10 incl. sub-types Sub-types →
- Inherited thyroid metabolism disease 0 trials · 8 incl. sub-types Sub-types →
- Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types Sub-types →
- Inborn vitamin metabolic disorder 0 trials · 7 incl. sub-types Sub-types →
- Inborn aminoacylase deficiency 0 trials · 6 incl. sub-types Sub-types →
- Disorder of peptide and amine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Congenital disorder of deglycosylation 0 trials · 2 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Hypercalcemia, infantile 2 trials Sub-types →
- Hypoalphalipoproteinemia, primary, 1 2 trials
- 2-hydroxyglutaric aciduria 0 trials · 1 incl. sub-types Sub-types →
- Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome 1 trial
- Diabetes mellitus, noninsulin-dependent, 1 1 trial
- Diabetes mellitus, noninsulin-dependent, 2 1 trial
- Familial hypocalciuric hypercalcemia 0 trials · 1 incl. sub-types Sub-types →
- Fish eye disease 1 trial
- Hereditary recurrent myoglobinuria 0 trials · 1 incl. sub-types Sub-types →
- Thiopurine metabolic disease 0 trials · 1 incl. sub-types Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- 5-nucleotidase syndrome 0 trials
- APO A-i deficiency 0 trials
- CFTR-related metabolic syndrome/CF screen positive, inconclusive diagnosis 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Lane Hamilton syndrome 0 trials
- NAD(P)HX dehydratase deficiency 0 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
- Achondrogenesis type IB 0 trials
- Antigen-peptide-transporter 2 deficiency 0 trials
- Apolipoprotein c-III deficiency 0 trials
- Aromatase excess syndrome 0 trials
- Atelosteogenesis type II 0 trials
- Autosomal dominant dopa-responsive dystonia 0 trials Sub-types →
- Autosomal dominant myoglobinuria 0 trials
- Autosomal dominant proximal renal tubular acidosis 0 trials
- Autosomal recessive proximal renal tubular acidosis 0 trials
- Cardiomyopathy hypogonadism metabolic anomalies 0 trials
- Chondrocalcinosis 2 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Defective apolipoprotein b-100 0 trials
- Deficiency of coenzyme q cytochrome c reductase 0 trials
- Diabetes mellitus, noninsulin-dependent, 3 0 trials
- Diabetes mellitus, noninsulin-dependent, 4 0 trials
- Diabetes mellitus, noninsulin-dependent, 5 0 trials
- Familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome 0 trials
- Ferro-cerebro-cutaneous syndrome 0 trials
- Gluthathione peroxidase deficiency 0 trials
- Hemolytic anemia due to diphosphoglycerate mutase deficiency 0 trials
- Hypercholesterolemia, familial, 4 0 trials
- Hypermanganesemia with dystonia 0 trials Sub-types →
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
- Hypoalphalipoproteinemia, primary, 2 0 trials Sub-types →
- Hypotonia-failure to thrive-microcephaly syndrome 0 trials
- Inborn disorder of aspartate family metabolism 0 trials Sub-types →
- Inborn glycerol kinase deficiency 0 trials Sub-types →
- Inherited threoninemia 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Normophosphatemic familial tumoral calcinosis 0 trials
- Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
- Striatonigral degeneration 0 trials Sub-types →
- Sulfide quinone oxidoreductase deficiency 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 1 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 2 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 3 0 trials
- Uridine-cytidineuria 0 trials
- Weinstein kliman scully syndrome 0 trials
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Proteostasis deficiencies 1 trial · 559 incl. sub-types
4 sub-types
- Amyloidosis 133 trials · 322 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- TDP-43 proteinopathy 2 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
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Hyperlipidemia 306 trials · 400 incl. sub-types
3 sub-types
- Familial hyperlipidemia 8 trials · 130 incl. sub-types Sub-types →
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Laminopathy type Decaudain-Vigouroux 0 trials
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Carbohydrate metabolism disease 4 trials · 384 incl. sub-types
6 sub-types
- Inborn carbohydrate metabolic disorder 3 trials · 369 incl. sub-types Sub-types →
- Carbohydrate transport disease 0 trials · 156 incl. sub-types Sub-types →
- Scurvy 13 trials
- Intestinal disaccharidase deficiency 0 trials · 2 incl. sub-types Sub-types →
- Acquired carbohydrate metabolism disease 0 trials
- Glycerol metabolism disease 0 trials
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Developmental anomaly of metabolic origin 0 trials · 383 incl. sub-types
57 sub-types
- Inborn mitochondrial metabolism disorder 59 trials · 127 incl. sub-types Sub-types →
- Fabry disease 64 trials
- Mucopolysaccharidosis 14 trials · 61 incl. sub-types Sub-types →
- Sterol biosynthesis disorder 0 trials · 45 incl. sub-types Sub-types →
- Fanconi anemia 29 trials · 42 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Oligosaccharidosis 0 trials · 11 incl. sub-types Sub-types →
- Pseudohypoparathyroidism 8 trials · 9 incl. sub-types Sub-types →
- Zellweger spectrum disorders 6 trials · 7 incl. sub-types Sub-types →
- Cockayne syndrome 6 trials Sub-types →
- Creatine transporter deficiency 6 trials
- Mucolipidosis 4 trials · 5 incl. sub-types Sub-types →
- Classic homocystinuria 4 trials
- Mucosulfatidosis 4 trials
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 2 trials
- AICA-ribosiduria 1 trial
- Nijmegen breakage syndrome 1 trial
- SLC35A2-congenital disorder of glycosylation 1 trial
- Arthrogryposis-renal dysfunction-cholestasis syndrome 1 trial Sub-types →
- Encephalopathy due to sulfite oxidase deficiency 0 trials · 1 incl. sub-types Sub-types →
- Occipital horn syndrome 1 trial
- ALDH18A1-related de Barsy syndrome 0 trials
- Al-Gazali syndrome 0 trials
- B4GALT1-congenital disorder of glycosylation 0 trials
- CADDS 0 trials
- CHIME syndrome 0 trials
- COG1-congenital disorder of glycosylation 0 trials
- COG7-congenital disorder of glycosylation 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Larsen-like syndrome, B3GAT3 type 0 trials
- MGAT2-congenital disorder of glycosylation 0 trials
- Neu-Laxova syndrome 0 trials Sub-types →
- Nijmegen breakage syndrome-like disorder 0 trials
- Peters plus syndrome 0 trials
- RFT1-congenital disorder of glycosylation 0 trials
- SHORT syndrome 0 trials
- SLC39A8-CDG 0 trials
- SSR4-congenital disorder of glycosylation 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- XYLT1-congenital disorder of glycosylation 0 trials
- Autism spectrum disorder - epilepsy - arthrogryposis syndrome 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Cutis laxa, autosomal dominant 3 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Hyperphosphatasia-intellectual disability syndrome 0 trials Sub-types →
- Mandibuloacral dysplasia 0 trials Sub-types →
- Mucopolysaccharidosis-plus syndrome 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 1 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 3 0 trials
- Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome 0 trials
- Pontocerebellar hypoplasia type 1 0 trials Sub-types →
- Progressive hypotonia-intellectual disability-facial dysmorphism syndrome due to FYVE-defective RBSN 0 trials
- Temtamy preaxial brachydactyly syndrome 0 trials
- Transketolase deficiency 0 trials
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Diabetic retinopathy 148 trials · 260 incl. sub-types
3 sub-types
- Diabetic macular edema 120 trials
- Background diabetic retinopathy 26 trials Sub-types →
- Proliferative diabetic retinopathy 19 trials
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Acquired metabolic disease 0 trials · 182 incl. sub-types
13 sub-types
- AL amyloidosis 92 trials · 98 incl. sub-types Sub-types →
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Acquired hyperprolactinemia 1 trial Sub-types →
- Auto-brewery syndrome 1 trial
- Acquired adrenogenital syndrome 0 trials
- Acquired carbohydrate metabolism disease 0 trials
- Acquired lactic acidosis 0 trials
- Acquired mineral metabolism disease 0 trials
- Acquired porphyria 0 trials Sub-types →
- Acquired xanthinuria 0 trials
- Bladder fermentation syndrome 0 trials
- Carotenemia 0 trials
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Amino acid metabolism disease 2 trials · 160 incl. sub-types
4 sub-types
- Inborn disorder of amino acid metabolism 6 trials · 159 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Disorder of organic acid metabolism 0 trials · 154 incl. sub-types
20 sub-types
- Disorder of phenylalanine metabolism 0 trials · 60 incl. sub-types Sub-types →
- Pyruvate metabolism disorder 0 trials · 31 incl. sub-types Sub-types →
- Disorder of fatty acid oxidation and ketogenesis 1 trial · 16 incl. sub-types Sub-types →
- Scurvy 13 trials
- Inborn disorder of bile acid synthesis 2 trials · 12 incl. sub-types Sub-types →
- Inborn disorder of methionine cycle and sulfur amino acid metabolism 0 trials · 11 incl. sub-types Sub-types →
- Disorder of tyrosine metabolism 0 trials · 8 incl. sub-types Sub-types →
- Cerebral creatine deficiency syndrome 0 trials · 6 incl. sub-types Sub-types →
- Inborn disorder of branched-chain amino acid metabolism 0 trials · 4 incl. sub-types Sub-types →
- Inborn disorder of ornithine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Biotin metabolic disease 0 trials · 3 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Gamma-amino butyric acid metabolism disorder 0 trials · 1 incl. sub-types Sub-types →
- Inborn serine deficiency 0 trials · 1 incl. sub-types Sub-types →
- Inherited lipoic acid biosynthesis defect 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Inborn disorder of histidine metabolism 0 trials Sub-types →
- Inborn disorder of proline metabolism 0 trials Sub-types →
- Inborn disorder of tryptophan metabolism 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Mineral metabolism disease 2 trials · 137 incl. sub-types
13 sub-types
- Calcium metabolic disease 5 trials · 62 incl. sub-types Sub-types →
- Phosphorus metabolism disease 1 trial · 33 incl. sub-types Sub-types →
- Iron metabolism disease 2 trials · 22 incl. sub-types Sub-types →
- Sulfur metabolism disease 0 trials · 14 incl. sub-types Sub-types →
- Potassium deficiency disease 4 trials · 5 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Achondrogenesis type IB 0 trials
- Acquired mineral metabolism disease 0 trials
- Atelosteogenesis type II 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
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Diabetic kidney disease 133 trials
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Hyperlipoproteinemia 8 trials · 106 incl. sub-types
4 sub-types
- Familial hypercholesterolemia 58 trials · 94 incl. sub-types Sub-types →
- Familial lipoprotein lipase deficiency 6 trials
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Hypercholesterolemia, familial, 4 0 trials
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Steroid metabolism disease 1 trial · 104 incl. sub-types
4 sub-types
- Sterol metabolism disorder 0 trials · 60 incl. sub-types Sub-types →
- Adrenogenital syndrome 0 trials · 41 incl. sub-types Sub-types →
- Vitamin D hydroxylation-deficient rickets, type 1B 3 trials
- Corticosterone methyloxidase type 1 deficiency 0 trials
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Gout 102 trials
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Hypertriglyceridemia 73 trials
2 sub-types
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
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Disorder of GPI anchor biosynthesis 0 trials · 73 incl. sub-types
11 sub-types
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 16 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 17 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 18 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 25 0 trials
- Inborn disorder of glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation 0 trials Sub-types →
- Neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures 0 trials
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Porphyrin metabolism disease 0 trials · 64 incl. sub-types
2 sub-types
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Porphyria 8 trials · 25 incl. sub-types Sub-types →
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Lipodystrophy 30 trials · 48 incl. sub-types
5 sub-types
- Partial lipodystrophy 7 trials · 19 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Generalized lipodystrophy 8 trials · 11 incl. sub-types Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Localized lipodystrophy 0 trials · 4 incl. sub-types Sub-types →
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Bilirubin metabolism disease 0 trials · 48 incl. sub-types
2 sub-types
- Inborn disorder of bilirubin metabolism 0 trials · 39 incl. sub-types Sub-types →
- Hyperbilirubinemia 28 trials Sub-types →
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Disorder of acid-base balance 6 trials · 28 incl. sub-types
1 sub-type
- Acidosis disorder 4 trials · 23 incl. sub-types Sub-types →
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Vitamin B12 deficiency 12 trials · 15 incl. sub-types
1 sub-type
- Inborn disorder of cobalamin metabolism and transport 1 trial · 3 incl. sub-types Sub-types →
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Purine metabolism disease 0 trials · 14 incl. sub-types
1 sub-type
- Inborn disorder of purine metabolism 0 trials · 14 incl. sub-types Sub-types →
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Pyrimidine metabolism disease 0 trials · 11 incl. sub-types
1 sub-type
- Inborn disorder of pyrimidine metabolism 0 trials · 11 incl. sub-types Sub-types →
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Lactic acidosis 8 trials
3 sub-types
- Acquired lactic acidosis 0 trials
- Cardiomyopathy-hypotonia-lactic acidosis syndrome 0 trials
- Mitochondrial DNA depletion syndrome 9 0 trials
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Chondrocalcinosis 5 trials · 7 incl. sub-types
3 sub-types
- Chondrocalcinosis due to apatite crystal deposition 2 trials
- Chondrocalcinosis 1 0 trials
- Chondrocalcinosis 2 0 trials
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Hypoalphalipoproteinemia 1 trial · 7 incl. sub-types
6 sub-types
- LCAT deficiency 1 trial · 4 incl. sub-types Sub-types →
- Apolipoprotein A-I deficiency 0 trials · 2 incl. sub-types Sub-types →
- Tangier disease 0 trials
- Apolipoprotein A-II deficiency 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Familial apolipoprotein gene cluster deletion syndrome 0 trials
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Glutaric aciduria 0 trials · 5 incl. sub-types
3 sub-types
- Glutaryl-CoA dehydrogenase deficiency 4 trials
- Multiple acyl-CoA dehydrogenase deficiency 1 trial Sub-types →
- Glutaric acidemia type 3 0 trials
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Tumor lysis syndrome 3 trials
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Dopa-responsive dystonia 1 trial · 2 incl. sub-types
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Ochronosis disorder 1 trial
1 sub-type
- Exogenous ochronosis 0 trials
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Xanthoma 1 trial
1 sub-type
- Verruciform xanthoma of skin 0 trials
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Xanthinuria 0 trials · 1 incl. sub-types
2 sub-types
- Hereditary xanthinuria 0 trials · 1 incl. sub-types Sub-types →
- Acquired xanthinuria 0 trials
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Collagenous sprue 0 trials
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Disorder of glutamate decarboxylase 0 trials
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Skeletal fluorosis 0 trials
Most studied deeper sub-types
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One-Time gene therapy aims to halt sanfilippo syndrome
Cure Not yet recruitingResearchers test a one-time gene therapy infusion in children and adults with Sanfilippo syndrome (MPS IIIB), a rare inherited disease that damages the brain and body. The therapy delivers a working copy of the NAGLU gene to help the body make an enzyme that is missing or faulty.…
Phase 1/2 • Sponsor: NeuroGT • Aim: Cure
Last updated Sep 16, 2026 00:00 UTC
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A new pill for obesity? early human trial puts HRS-1597 to the test
Disease control Not yet recruitingResearchers are running a Phase 1 trial of HRS-1597, an experimental tablet for obesity and metabolic disorders. The study gives single doses to healthy volunteers and multiple doses to obese participants to check safety, tolerability, and how the drug moves through the body. It …
Phase 1 • Sponsor: Shandong Suncadia Medicine Co., Ltd. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Glucose monitors may guide teens away from diabetes
Disease control Not yet recruitingThis study tests whether giving teens with obesity and prediabetes a continuous glucose monitor (CGM) — along with nutritional counseling — helps them eat better and keep blood sugar in check. For three months, participants see their glucose levels in real time and learn how diff…
Sponsor: University of Florida • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New shot could help teens with rare, severe high cholesterol
Disease control Not yet recruitingThis study tests a new drug called zodasiran in 12 teens aged 12 to 17 with homozygous familial hypercholesterolemia, a rare genetic condition causing very high cholesterol. The drug is given as a shot under the skin. The main goal is to see if it safely lowers bad cholesterol af…
Phase 3 • Sponsor: Arrowhead Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Shocking weight loss? new study tests electric muscle stimulation plus diet
Disease control Not yet recruitingThis study will test whether adding whole-body electrical muscle stimulation (EMS) to a reduced-calorie diet helps people with obesity lose weight and improve metabolic health. Forty adults will be randomly assigned to either diet alone or diet plus EMS for 8 weeks. Researchers w…
Sponsor: Firat University • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New digital toolkit aims to transform care for millions with multiple chronic diseases
Disease control Not yet recruitingThis study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…
Sponsor: Centre for Chronic Disease Control, India • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Muscle cells grown in lab to be injected into bedridden patients
Disease control Not yet recruitingThis very early trial will test whether injecting a patient's own lab-grown muscle cells under the skin is safe for people with muscle atrophy from long-term bed rest. Only 6 participants will receive the transplant and be closely monitored for side effects and signs of muscle re…
Early phase 1 • Sponsor: National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Could a heart drug fix metabolism in black obesity?
Disease control Not yet recruitingThis study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measurin…
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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A breath sniff could one day screen for lung cancer and more
Diagnosis Not yet recruitingResearchers are testing whether an electronic nose that analyzes exhaled breath can serve as a noninvasive prescreening tool for several diseases at once. The study plans to enroll up to 20,000 adults and will first standardize the breath-sampling procedure, then evaluate how wel…
Sponsor: The First Affiliated Hospital of Guangzhou Medical University • Aim: Diagnosis
Last updated Sep 06, 2026 00:00 UTC
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Virtual platform aims to cut HIV comorbidities
Prevention Not yet recruitingThis study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…
Sponsor: Yale University • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC
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Can tiny tablets replace protein powder for kids with PKU?
Symptom relief Not yet recruitingThis trial tests whether XPhe Piccos, a slow-release protein substitute in tiny tablets without phenylalanine, is acceptable and well-tolerated in children aged 3 and older with phenylketonuria (PKU) or hyperphenylalaninemia. Participants replace some or all of their usual protei…
Sponsor: metaX Institut fuer Diatetik GmbH • Aim: Symptom relief
Last updated Sep 05, 2026 00:00 UTC
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Laser zaps belly fat? new study tests metabolism-boosting light treatment
Symptom relief Not yet recruitingThis pilot study at Massachusetts General Hospital will test whether applying a fractional laser to the abdomen and thighs can improve metabolism in adults with overweight. Fifteen participants will receive three laser treatments, four weeks apart. Researchers will measure change…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Belt vs. belt and suspenders: which stomach suture pattern wins for weight loss?
Symptom relief Not yet recruitingThis study tests if placing stitches only in the lower part of the stomach works as well as placing stitches in both the lower and upper parts for weight loss. Ten adults with obesity will get one of the two stitch patterns using a device called Endomina. Researchers will track h…
Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Massive 30-Year study aims to unlock secrets of diabetes and obesity
Knowledge-focused Not yet recruitingThis study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Can AI help surgeons pick the right gut length in Weight-Loss surgery?
Knowledge-focused Not yet recruitingResearchers are studying whether three body measurements can help predict how well patients do after one-anastomosis gastric bypass. The measurements are the percentage of a laparoscopic instrument segment covered by fat, the total length of the small bowel, and a calculated abdo…
Sponsor: The Society of Bariatric and Metabolic Surgeons of Kazakhstan • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Sugar tracer reveals how immune cells fuel up in the ICU
Knowledge-focused Not yet recruitingResearchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
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Fasting plus fibre: a Gut-Boosting combo?
Knowledge-focused Not yet recruitingThis study explores whether taking a dietary fibre supplement during a 10-day fast can improve gut health and metabolism more than fasting alone. Overweight adults (BMI 25 or higher) will fast at a clinic and then either receive a resistant starch fibre or a placebo. Researchers …
Sponsor: Buchinger Wilhelmi Development & Holding GmbH • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Can a One-Day class help people with obesity? new study aims to find out
Knowledge-focused Not yet recruitingThis study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…
Sponsor: CHU de Quebec-Universite Laval • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Family metabolism mystery: are you burning calories like mom or dad?
Knowledge-focused Not yet recruitingThis study explores whether resting metabolic rate (the calories your body burns at rest) runs in families. Researchers will measure metabolism and body composition in 30 biological parent-adult child pairs. The goal is to understand how much of our metabolism is inherited, which…
Sponsor: Tel Aviv University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Scientists hunt for diabetes genes in caribbean populations
Knowledge-focused Not yet recruitingThis study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes…
Sponsor: Centre Hospitalier Universitaire de la Guadeloupe • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Scientists probe hidden body changes after Weight-Loss procedure
Knowledge-focused Not yet recruitingThis study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Massive study to uncover how obesity and diabetes speed up liver damage
Knowledge-focused Not yet recruitingThis study follows over 4,300 adults with compensated advanced chronic liver disease to see how metabolic disorders like obesity, diabetes, and high cholesterol affect disease progression. Participants receive standard care and are monitored every 3 to 6 months for up to 5 years.…
Sponsor: The Second Affiliated Hospital of Chongqing Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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100,000 seniors studied to uncover links between diabetes, heart risk, and kidney disease
Knowledge-focused Not yet recruitingThis observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…
Sponsor: Chinese PLA General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Massive biobank aims to unlock secrets of obesity
Knowledge-focused Not yet recruitingThis study will gather medical data and blood samples from up to 25,000 adults with obesity who visit a special clinic. Researchers hope to learn more about why obesity happens, what treatments work best, and how to improve patients' health. No new treatments are being tested; in…
Sponsor: Institut universitaire de cardiologie et de pneumologie de Québec, University Laval • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Gut check: could your microbiome be key to obesity and diabetes?
Knowledge-focused Not yet recruitingThis study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…
Sponsor: Institut Pasteur • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Do household chemicals fuel breast cancer? new study aims to find out.
Knowledge-focused Not yet recruitingThis study looks at whether chemicals called endocrine disruptors (found in plastics, food, and everyday items) are linked to breast cancer. Researchers will measure these chemicals in urine, hair, and breast fat from 42 women scheduled for breast lesion surgery. The goal is to u…
Sponsor: Poitiers University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Scientists hunt for clues in gut and urine to understand urinary blockages
Knowledge-focused Not yet recruitingThis observational study will compare the gut and urine bacteria, as well as metabolic profiles, of 120 people with ureteral stricture (a narrowing of the tube from kidney to bladder) against healthy volunteers. Researchers aim to find differences that could explain why the condi…
Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New digital health tool aims to simplify care for patients with multiple chronic illnesses
Knowledge-focused Not yet recruitingThis study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…
Sponsor: Centre for Chronic Disease Control, India • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Scientists hunt for biomarkers to personalize ventilator care in ARDS
Knowledge-focused Not yet recruitingThis observational study will analyze blood and sputum samples from 411 adults with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers will look for patterns in microbes, metabolites, and gene activity to see if they can predict how well patients respo…
Sponsor: Ruijin Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Normal weight, hidden danger: new study seeks to unmask 'Skinny Fat' risk
Knowledge-focused Not yet recruitingThis study looks at a condition called 'metabolically obese normal weight' (MONW), where people have a healthy BMI but too much body fat, raising their risk for heart problems and diabetes. Researchers will study 176 young women with normal weight, measuring body fat, blood marke…
Sponsor: Pomeranian Medical University Szczecin • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Massive study to uncover hidden risks in heart patients with metabolic issues
Knowledge-focused Not yet recruitingThis study will follow about 3,500 adults in China who have atrial fibrillation (an irregular heartbeat) along with metabolic disorders like obesity, diabetes, or high cholesterol. Researchers want to learn how these combined conditions affect risks for stroke, heart failure, and…
Sponsor: Xiangya Hospital of Central South University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New study to decode PET-CT patterns in elderly lymphoma patients
Knowledge-focused Not yet recruitingThis study will examine PET-CT scan images from 63 patients aged 60 and older who have lymphoma. The goal is to describe the patterns and metabolic activity seen on the scans, which may help doctors better diagnose and predict the course of the disease. No new treatments are bein…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Massive diabetes registry aims to unlock secrets of metabolic disease
Knowledge-focused Not yet recruitingThis 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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New index may simplify metabolic health check
Knowledge-focused Not yet recruitingThis observational study will check if a new scoring system called the Nutrilite Metabolic Health Index matches results from detailed blood tests. About 200 healthy adults aged 18 to 60 will fill out questionnaires and give blood samples. No treatment or intervention is given—the…
Sponsor: Amway (China) R&D Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:55 UTC