Meningioma

This study tests a higher dose of a precise type of radiation called proton therapy for people with aggressive meningiomas (brain tumors). The goal is to find a safe dose that can better control the tumor after surgery. The study includes 21 participants with either grade II or g…

This study is for people with a rare, aggressive brain tumor called high-grade meningioma that has come back after radiation. It tests whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to precise, high-dose radiation can help shrink the tumor or slow its g…

This phase 2 trial is testing the drug abemaciclib in people whose primary brain tumors have come back after initial treatment. The goal is to see if the drug can shrink tumors or slow their growth. Participants take abemaciclib pills twice daily, and some take it before surgery …

This phase 2 trial tests two immunotherapy drugs, nivolumab and ipilimumab, in 40 adults with progressive or recurrent meningioma. One group receives nivolumab alone; the other gets both drugs after radiation therapy. The goal is to see if these treatments can stop tumor growth f…

This pilot study tests an experimental device called Optune in people with recurrent atypical or anaplastic meningioma, a type of brain cancer that has come back after surgery or radiation. The device delivers electric fields to the tumor area to try to stop cancer cells from gro…

This study tested the immunotherapy drug pembrolizumab in 26 people with high grade meningioma that came back or remained after treatment. The goal was to see if the drug could stop the tumor from growing for at least 6 months. Participants received pembrolizumab and had regular …

This study tests whether giving pregabalin before brain tumor surgery can safely reduce pressure inside the skull. One hundred adults will receive either pregabalin or a placebo before and on the morning of surgery. Researchers will measure pressure using a painless eye ultrasoun…

This phase II trial tests whether combining stereotactic radiosurgery (precise, high-dose radiation) with the immunotherapy drug pembrolizumab (Keytruda) can help control recurrent meningioma, a type of brain tumor. The study enrolls 35 adults whose tumors have returned after pri…

This study tests a drug called Lutathera, which delivers radiation directly to tumor cells, in 32 adults with a type of brain tumor called meningioma that is growing or hard to treat. Participants receive four doses of the drug through an IV, 8 weeks apart. The main goal is to se…

This trial tests whether the drug ribociclib can reach brain tumors in people with recurrent high-grade glioma or meningioma. About 48 participants take the drug before their scheduled tumor-removal surgery. The goal is to measure how much drug gets into the tumor and surrounding…

This study planned to test an oral drug called ONC201 (dordaviprone) in people with a type of brain tumor called meningioma that had come back or was not responding to other treatments. One group would have taken the drug before surgery to see how much reached the tumor, and anot…

This early-phase trial tests whether giving higher doses of radiation, guided by special PET/MRI scans, is safe for people with high-risk meningiomas (aggressive or recurrent brain tumors). About 24 adults will receive one of four radiation dose levels to find the highest dose th…

This study will compare two types of PET scans (using different radioactive tracers) in 6 adults with suspected meningioma who are scheduled for surgery. Each person will get both scans at least 24 hours apart. The goal is to see which tracer gives clearer images of the tumor, wh…

This study tests whether a new type of PET/CT scan, using a radioactive tracer called 68Ga-DOTATOC, can find neuroendocrine tumors (NETs) and similar tumors more safely and accurately than current imaging methods. About 800 people with known or suspected NETs will receive the sca…

This study compares three different PET/CT scans (68Ga-HA-DOTATATE, 18F-DOPA, and 18F-FDG) in 50 people with metastatic neuroendocrine tumors. The goal is to see if all tumors show up on the standard scan or if some are missed, which could change treatment. Participants will get …

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study looks at epigenetic changes in meningioma tumors and blood samples to find markers that could predict if the tumor will come back after surgery. Researchers will analyze tissue from past patients and collect blood from new patients. The goal is to improve personalized …

This study looks at whether adding a breath-holding task to standard brain scans can make mapping of important brain areas more accurate in people with brain tumors. About 33 patients and healthy volunteers will have functional MRI scans while doing language tasks, with and witho…

This study tests whether a drug called 5-ALA can make brain tumor cells glow during surgery, helping surgeons see and remove the entire tumor. About 540 adults with brain tumors will receive 5-ALA before surgery, and doctors will measure how well the glow matches actual tumor tis…

This study is testing whether advanced MRI scans can predict which meningioma patients will experience cognitive decline after radiotherapy. Researchers will follow 67 patients for two years, using cognitive tests and brain imaging before and after treatment. The goal is to ident…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study tracks 80 patients with brain tumors (metastases or meningiomas) who receive stereotactic radiosurgery. Researchers use memory tests and quality-of-life questionnaires before treatment and every 3 months for a year to see if and how brain function changes. By comparing…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study looks at 200 people with brain tumors to see if special MRI scans can reveal details about the tumor's immune environment. Participants will have an MRI before surgery. The goal is to learn more about brain tumors, not to test a new treatment.