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Blood test may predict brain tumor return

NCT ID NCT07282470

Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study looks at epigenetic changes in meningioma tumors and blood samples to find markers that could predict if the tumor will come back after surgery. Researchers will analyze tissue from past patients and collect blood from new patients. The goal is to improve personalized care for people with this common brain tumor.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a blood test that helps doctors predict which meningiomas are likely to come back after surgery.
What could go wrong
This is an observational study, not a treatment trial. The findings may not lead to immediate changes in patient care, and the epigenetic markers may not prove reliable in larger, diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with Meningioma

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria (Retrospective \& Prospective): * Patient aged 18 years or older. * First diagnosis of uni-focal meningioma of the convexity. * Macroscopical total resection (Simpson 1-3). (Retrospective only): * Surgery performed between 2007 and 2016; * availability of FFPE sample and medical records. Exclusion Criteria: * Genetic syndromes. * Diffuse Meningeal Meningiomatosis. * Patients who underwent experimental treatment in neo-adjuvant setting. (Prospective only): * Previous surgical/medical treatment for another meningioma; * positive oncological history (e.g., breast cancer).

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Conditions

The condition(s) this trial relates to.

intracranial meningioma meningioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Meningioma Meningioma of brain

Contacts and locations

Locations

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    Milan, Italy

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