Could a common pain pill protect the brain during surgery?

NCT ID NCT07630753

Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving pregabalin before brain tumor surgery can safely reduce pressure inside the skull. One hundred adults will receive either pregabalin or a placebo before and on the morning of surgery. Researchers will measure pressure using a painless eye ultrasound instead of an invasive brain monitor.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: pregabalin
What this could lead to: If it works, this could offer a simple, non-invasive way to manage brain pressure during surgery and speed up recovery.
What could go wrong: This is a small, early-phase study using an indirect pressure measurement. The drug may not reduce pressure meaningfully, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18-65 years 2. ASA status: I-III 3. Surgery Elective supratentorial craniotomy for tumor resection (meningioma, glioma, metastasis) 4. Anesthesia: General anesthesia with sevoflurane 5. Consent: Written informed consent obtained Exclusion Criteria: 1. Known hypersensitivity to pregabalin or gabapentinoids. 2. Pre-existing optic nerve pathology or glaucoma that could cause ONSD measurement interference. 3. Emergency surgery as No preoperative dosing window 4. Preoperative ICP elevation (suspected or confirmed) to avoid Baseline ICP abnormality 5. Severe renal impairment (CrCl \< 30 mL/min). 6. Preoperative use of gabapentinoids or benzodiazepines to avoid drug interaction/interference 7. Pregnancy or breastfeeding for Safety 8. Body mass index \> 40 kg/m² 9. History of substance abuse 10. Inability to cooperate with ONSD measurement

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioma meningioma metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracranial pressure changes Optic nerve sheath diameter measurement Pregabalin

Could a common pain pill protect the brain during surgery?

What the study statuses mean