Liver cancer

This phase 1 trial tests whether a personalized vaccine made from a patient's own immune cells can safely boost the body's defenses against liver cancer. People with early-stage hepatocellular carcinoma receive either microwave ablation alone or ablation followed by seven doses o…

This phase 2 pilot study tests whether combining the immunotherapy drug pembrolizumab (Keytruda) with liver-directed treatments (like embolization or radiation) or peptide receptor radionuclide therapy (PRRT) can shrink tumors in people with well-differentiated neuroendocrine tum…

This trial is testing whether a chemotherapy drug called idarubicin works as well as the standard drug doxorubicin when used in a procedure called transarterial chemoembolization (TACE) for liver cancer. TACE delivers chemotherapy directly to the tumor and blocks its blood supply…

This early-phase study tests whether combining the immune-boosting drug nivolumab with a procedure that delivers chemotherapy directly to liver tumors (called deb-TACE) is safe for people with advanced liver cancer. Twenty participants will receive the combination, and researcher…

This study looked at whether adding focused radiation (SBRT) or surgery to standard treatments like chemo or hormone therapy helps people with breast cancer that has spread to just one or two places. 129 participants were randomly assigned to get standard care alone or standard c…

This trial investigates whether JX-594 (Pexa-Vec), a virus modified to attack cancer cells and boost the immune system, combined with best supportive care, can help people with advanced liver cancer live longer. The study enrolls adults whose liver cancer has progressed or who co…

This trial investigates whether combining two immunotherapy drugs (ipilimumab and nivolumab) with a procedure called immunoembolization can help people whose uveal melanoma has spread to the liver. The drugs help the immune system attack cancer cells, while immunoembolization cut…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This early-phase study tested a new treatment called JX-594, a modified virus injected directly into liver tumors. The goal was to find the safest dose and see if it could shrink tumors in 14 patients with advanced liver cancer that had not responded to standard treatments. The s…

This completed registry tracked 332 liver cancer patients in France who received SIR-Spheres, tiny radioactive beads injected into the liver's blood supply to target tumors. The goal was to see how this treatment is used in everyday practice and to monitor safety and survival. Re…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This study tested a method to protect healthy liver tissue during Yttrium-90 radioembolization, a radiation treatment for liver cancer. Doctors injected short-acting gelatin particles into arteries supplying non-cancerous liver areas to temporarily block blood flow. The goal was …

This study tested a new combination treatment for people with advanced liver cancer or bile duct cancer. The treatment combines an immunotherapy drug (SHR-1210) with either a targeted therapy (apatinib) or chemotherapy. The goal was to see if the combination is safe and can shrin…

This study tested a combination of two drugs, relatlimab and nivolumab, in 266 adults with advanced liver cancer who had not received immunotherapy before but whose cancer worsened after other treatments. The goal was to see if the combination could shrink tumors or control the d…

This study tested a new treatment for people with liver cancer that cannot be removed by surgery. The treatment combines chemotherapy delivered directly to the liver, a procedure to block the tumor's blood supply, and two drugs (lenvatinib and tislelizumab). The goal was to see i…

This study tested two chemotherapy drugs, cisplatin and mitomycin-C, given directly into the liver artery for people with liver cancer that cannot be surgically removed. The goal was to see how long tumors stay controlled and to track side effects. 76 participants were enrolled. …

This study tested proton beam radiation, a highly targeted form of radiotherapy, in 83 people with liver cancer that could not be surgically removed. The goal was to see if this precise approach could control tumors while reducing damage to healthy tissue. Participants received d…

This phase 2 trial tested colchicine, a drug usually used for gout, in 42 people with advanced liver cancer that could not be treated with curative intent. Participants took colchicine tablets daily in cycles of 4 days on, 3 days off. The study measured how long patients survived…

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

This study looked at blood samples from 573 people to find new markers that could diagnose liver cancer more accurately. Researchers compared samples from patients with liver cancer, those with other liver conditions, and people with hepatitis infections. The goal is to improve u…

This study tested whether a shorter, contrast-enhanced MRI (called AMRI) is better than standard ultrasound for finding liver cancer early in people with cirrhosis. 79 adults with cirrhosis underwent both scans, and researchers compared how accurately each method detected cancer.…

This study by Mayo Clinic tested whether analyzing chemicals in a person's breath could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants and looked for unique patterns of volatile organic c…

This study tested whether a special ultrasound with contrast dye (CEUS) can more accurately identify liver lesions than standard ultrasound or other imaging methods like CT and MRI. Researchers enrolled 878 participants with liver lesions found on standard ultrasound. The goal wa…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This study compares two ways to manage pain after open liver surgery: a newer erector spinae plane block (ESPB) and the standard thoracic epidural. Sixty adults having elective open liver resection will be randomly assigned to one method. The goal is to see if ESPB provides simil…

This study tested whether a personalized diet plan helps liver cancer patients eat more and recover faster after surgery. 139 patients who had part of their liver removed were split into two groups: one got standard care, the other got a custom meal plan with extra protein drinks…

This study tested whether giving lidocaine through a vein during and after liver surgery can reduce pain and the need for strong painkillers like opioids. 124 adults having minor liver surgery were randomly assigned to receive either lidocaine or a placebo (salt water). Researche…

This study gathers blood, urine, stool, and tissue samples from 132 adults with primary liver cancer who are receiving or have received immunotherapy. Researchers will analyze these samples along with medical records to learn more about how liver cancer develops and responds to t…

This study tested a new cone-beam CT scanner that takes clearer pictures during radiation therapy for lung, liver, and breast cancers. 31 people participated to see if the new scanner reduces image blurring and improves accuracy. The goal is to help doctors target tumors more pre…

This study compares two catheters used during the mapping step before radioembolization for liver cancer. One is a standard microcatheter, the other is a pressure-enabled device (TriNav). The goal is to see if the pressure-enabled catheter delivers more radioactive tracer directl…

This study looked at whether combining detailed MRI scans with whole genome sequencing can help doctors choose the best treatment for people with liver cancer. Researchers studied 200 adults who were scheduled for liver surgery. The goal was to see if these advanced tests provide…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at whether liver cancer spreads differently in men and women. Researchers analyzed data from over 19,000 patients and used computer models to create separate prediction tools for each gender. The goal was to better understand risk factors for cancer spread at th…

This study compared two surgical tools—surgical loupes (magnifying glasses) and a microscope—for repairing bile ducts during living donor liver transplants. 52 adults receiving a right-lobe liver graft with a single bile duct opening took part. The goal was to see which tool led …

This study gathered information from 12 people with fibrolamellar cancer (FLC) around the world. Participants shared their medical history and regular care details through an online registry. The goal was to create a database for future research, not to provide treatment.

This study looked at 379 people with liver cancer to see if monitoring changes in blood markers over time could help doctors better predict how the disease will progress. Researchers combined these marker trends with patient information to build a more accurate risk model. The go…