Kidney neoplasm

This study tests a new medicine, PF-08634404, in adults with advanced kidney cancer that has spread. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer drugs. About 224 participants who have not had prior treatment for their advanced…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study is testing a non-invasive radiation treatment called SABR for people with kidney tumors who are not good candidates for surgery. The goal is to control the tumor while keeping the kidneys working well. About 90 participants will receive high-dose radiation and be follo…

This study tests a procedure called EUS-guided radiofrequency ablation (RFA) for solid tumors in the stomach, liver, kidney, or adrenal glands. It involves using an endoscope to insert a needle that heats and destroys tumor tissue. The study will enroll 30 adults who cannot have …

This phase 2 trial is testing whether the drug casdatifan, alone or with zimberelimab, can safely shrink kidney tumors before surgery in people with clear cell renal cell carcinoma. About 32 adults with advanced or high-risk kidney cancer will receive the drugs before their plann…

This study tests whether using a low-sodium, potassium-enriched salt substitute instead of regular salt can help protect kidney function in people who have had surgery for a kidney tumor. Two hundred adults who had a partial or full kidney removal will either use the salt substit…

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after their first one stopped working. The study will track how long the cancer stays under…

This study tests whether artificial intelligence can analyze MRI images to identify the type and aggressiveness of kidney tumors. Researchers will use scans from about 900 adults who have had surgery for kidney tumors, comparing AI predictions with the actual pathology results. T…

This study is testing whether a combined PET and MRI scan (PET/MR) can better tell apart aggressive kidney cancers from slow-growing or harmless tumors. About 97 adults with a suspicious kidney mass will receive the scan during their regular MRI appointment. Researchers hope this…

This study is testing a new ultrasound imaging method called Contrast Enhanced Super-Resolution (CESR) to see if it can better detect and tell apart cancerous and non-cancerous lesions in the breast, liver, and kidney. It involves 40 participants: 10 healthy volunteers to fine-tu…

This study tests whether special MRI and CT scans can accurately measure the stiffness of kidney tumors. Researchers will compare these scans to standard methods in 50 adults scheduled for kidney tumor surgery. The goal is to improve 3D-printed models that help surgeons plan oper…

This study tests a new radioactive imaging agent called [18F]RCCB6 for PET/CT scans to see if it can better detect kidney cancer, especially the most common type, clear cell renal cell carcinoma. Researchers will enroll 300 adults with confirmed or suspected kidney cancer. The go…

This study is testing a precise form of radiation called proton beam therapy for children and young adults with kidney tumors like Wilms tumor. The goal is to see if this approach causes fewer short-term side effects compared to standard radiation. About 28 participants will rece…

This study compares two ways to position patients during robot-assisted surgery to remove small kidney tumors. One group lies on their side (standard flank position), while the other lies on their back (supine position). The goal is to see which position leads to fewer complicati…

This study tests a software tool called RUS NE that creates a 3D model of a patient's kidney tumor and nearby blood vessels. Surgeons use it as a navigation guide during robot-assisted partial nephrectomy. The trial involves 204 adults with kidney tumors up to 7 cm, split into tw…

This study tests whether a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can control pain after robotic kidney surgery better than standard opioids. About 110 adults having a partial nephrectomy for kidney cancer will be randomly assigned to receive either ketorol…

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers will collect blood, saliva, and tissue samples from up to 950 participants to find the genes involved and understand how kidney tumors grow. Th…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Researchers are testing whether hyperspectral imaging, a camera technique that captures hundreds of light bands invisible to the eye, can map blood flow and identify tumor types during robot-assisted partial nephrectomy. The study will enroll 60 adults with kidney tumors up to 7 …

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to understand how cancer treatments like radiation, chemotherapy, and surgery affect health years later. By comparin…

This study is looking for better ways to decide on treatment for small kidney tumors (up to 4 cm). Researchers will combine MRI scans with detailed analysis of tumor tissue samples to see if they can predict which tumors are aggressive. The goal is to help doctors choose the best…

This study is for people with small kidney tumors (4 cm or less). It compares two approaches: active surveillance (regular monitoring) and immediate treatment (surgery or other procedures). The goal is to see if watching the tumor is as safe and effective as treating it right awa…

This study aims to create immune organoids—tiny lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will mix these organoids with tumor cells to see how they interact. The goal i…

This study looks at whether a simple blood test that finds bits of tumor DNA can help doctors monitor kidney cancer after surgery. Researchers will follow 450 people who have just been diagnosed with kidney cancer and are having surgery to remove it. The goal is to see if the blo…

This study tests a web-based decision aid for people with small kidney tumors (up to 4 cm). The tool provides personalized information about treatment options and their risks and benefits. Researchers will enroll 40 patients to see if the tool improves knowledge, satisfaction, an…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic changes that cause these tumors and how they affect health. Up to 2,000 patients and their family members will provide DNA sampl…