Kidney failure

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This pilot study tests whether using a cap containing chlorhexidine on dialysis catheters can reduce infections compared to standard caps. Sixty adults with kidney failure who need dialysis through a central line will be randomly assigned to one of the two caps. The main goal is …

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with fluid buildup because standard treatments remove it too quickly, causing heart and brain damage. The device is worn at home for a few hours after…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests whether cooling the dialysis fluid slightly can help preserve memory and thinking in people with kidney failure who need hemodialysis. Many patients on dialysis experience a decline in brain function, possibly due to drops in blood flow during treatment. The tria…

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

People with advanced kidney disease often face fatigue, itching, pain, and sleep problems that disrupt daily life and strain caregivers. Researchers are testing a nurse-led program called COMFORT that helps patients and their informal caregivers recognize and manage these symptom…

This study looks at whether hydromorphone sustained-release tablets can safely relieve moderate to severe cancer pain in elderly patients who also have kidney issues. Researchers will compare these patients to those with normal kidney function, monitoring pain relief, kidney func…

Doctors often see creatinine rise in patients taking vancomycin plus piperacillin-tazobactam, a common antibiotic pair. It is unclear whether that rise means real kidney injury or a harmless lab change. This study follows 304 adults on either that pair or vancomycin plus meropene…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study follows 190 adults with chronic kidney disease who are not yet on dialysis. Over 24 months, researchers track clinical and lab measures to see who experiences a rapid drop in kidney function, defined as a sustained decline of more than 5 mL/min per year. The goal is to…

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This trial tests how the drug PKN605 moves through the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers give a single oral dose and measure drug levels in the blood over time. The goal is to see if reduced kidney function increa…

This trial is investigating how different levels of kidney function affect the way the body processes a single dose of the antibiotic afabicin. About 60 adults with varying degrees of kidney impairment, from mild to severe, will receive either an oral tablet or an intravenous inf…

This study looks back at medical records of critically ill adults who needed emergency dialysis in the emergency department. It compares two methods—standard hemodialysis and a continuous version called CVVHDF—to see how patients fare during their hospital stay. The main focus is…

This study looks at how the drug D-2570 moves through the body in people with reduced kidney function compared to those with normal kidneys. About 40 adults aged 18 to 70 will receive a single dose of D-2570. Researchers will measure drug levels in the blood and monitor for side …

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study will follow 225 adults with end-stage kidney disease who are on regular dialysis. Researchers want to see if missing a dialysis session raises the risk of heart problems like heart attack or stroke within the next 72 hours. Participants will have heart tests after a mi…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study looks at how the blood thinner enoxaparin works in critically ill ICU patients with kidney failure, some on dialysis and some not. Researchers will measure drug levels in the blood over 24 hours after a daily shot. The goal is to see if current dosing is enough to prev…

This study looks at ICU patients with kidney failure who need blood thinners to prevent dangerous clots. Doctors currently use different types of heparin, but it's unclear which is safest and works best when kidneys are weak. The study will track over 1,100 patients to compare bl…

This study looks at how the drug anaprazole sodium is processed by the body and whether it is safe for people with liver or kidney issues, as well as for older adults. About 60 participants will be enrolled to measure drug levels and track any side effects. The goal is to underst…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…