Intermediate coronary syndrome

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study compares two types of drug-coated stents (SYNERGY and BioMatrix NeoFlex) in 160 patients with coronary artery disease. Researchers use a special camera to check how well the stents heal inside the artery at 1 and 3 months after placement. The goal is to see which stent…

This study looked at whether using a person's genetic information to choose their blood thinner medication after getting a heart stent can reduce the risk of heart attacks, strokes, and death. About 4,000 people with heart disease were given either clopidogrel or ticagrelor based…

This study tests a device called a coronary sinus reducer in 50 people with chest pain caused by coronary microvascular disease, a condition where small heart vessels don't work properly. The device is implanted to narrow a heart vein, which may improve blood flow. Half the parti…

This study looks at a new way to treat severe, long-term blockages in heart arteries (CTO). Instead of one long procedure, doctors will plan two shorter procedures. The goal is to see if this approach is safer, more successful, and better for patients. About 200 people with high-…

This study tests a new balloon catheter coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is inserted through a small tube and inflated to push plaque against the artery wall, releasing medication to keep the artery…

This study will follow 800 adults in Turkey with high blood pressure or chronic chest pain (angina) who are already taking benidipine. Researchers will track how well the drug controls blood pressure and eases chest pain symptoms over time. The goal is to see how benidipine works…

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether a special heart function test can guide treatment to improve symptoms and quality of life. 108 participants will be randomly assigned to either treatment guided by the tes…

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study tests whether personalized risk models can safely reduce the number of diagnostic tests for people with new chest pain. Researchers will enroll 2,000 adults aged 30-75 and compare the model-based approach to standard care. They will also test a new laser method to meas…

This study is testing a device called the Neovasc Reducer in 400 people with chronic stable angina who have not found relief from standard treatments. The device is implanted to improve blood flow and reduce chest pain. Researchers will track symptom improvement and any serious s…

This study follows 200 adults in Western Denmark who are having a transcatheter aortic valve implantation, a procedure to replace a narrowed heart valve. Researchers will measure quality of life before the procedure and at follow-up using a standard questionnaire. They will also …

This study looks at 320 people with complex coronary artery disease who need a stent. It compares using a special camera (OCT) versus standard X-ray (angiography) to guide the stent placement. The goal is to see which method leads to better blood flow after the procedure.

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This observational study will enroll about 8,000 adults across Europe who have coronary heart disease or are at high risk for it, including those with diabetes or chronic kidney disease. Researchers will check whether doctors are following European guidelines for lifestyle advice…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

The ORACLE study is testing a new way to evaluate people with possible angina (chest pain) within one day of their doctor's referral. Participants fill out a digital health questionnaire at home, then have an ECG and a blood test for heart damage markers. The goal is to see if th…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study looks at three ways to treat severely hardened heart arteries before placing a stent: using sound waves (lithotripsy), a high-pressure balloon, or a tiny rotating device (orbital atherectomy). The goal is to see how each method affects the small blood vessels in the he…