Hypertensive disorder

This completed trial tested whether a cellular-enabled blood pressure cuff, used at home, could help cancer patients on the drug bevacizumab better track and manage high blood pressure. Twenty participants were randomly assigned to use the smart cuff or a standard cuff. The goal …

This trial tests whether a 6-month telehealth program can reduce stroke risk factors, especially high blood pressure, in people already at elevated risk. Participants receive personalized remote care including blood pressure monitoring, wearable tracking, and virtual visits with …

People with chronic kidney disease (CKD) often have an overactive sympathetic nervous system, which raises their risk of heart problems and death. This phase 4 trial tests whether pioglitazone, a drug usually used for diabetes, can reduce that nerve overactivity and improve blood…

This study tested whether a 6-month program of nurse-led phone calls could help women with uncontrolled high blood pressure take their medication as prescribed. The program included 7 phone calls to address barriers to medication adherence. Only 14 women enrolled before the study…

This trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…

This trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…

This study looked at how different amounts of potassium supplements affect blood pressure in adults with high blood pressure. Researchers aimed to find the best potassium level to help lower blood pressure. The study was stopped early and included 25 participants.

This Phase 3 trial tested the drug sotatercept in 321 people newly diagnosed with intermediate- or high-risk pulmonary arterial hypertension (PAH). Participants received either sotatercept or a placebo added to their usual PAH therapy. The goal was to see if sotatercept could del…

This study looked at the long-term safety of an inhaled drug called treprostinil in people who have both pulmonary hypertension (high blood pressure in the lungs) and COPD. It included 41 adults who had already completed a previous study. The trial was terminated early, and the m…

This study looked at the long-term safety and effects of a procedure called renal denervation in 9 patients with resistant hypertension (high blood pressure that doesn't respond to multiple medications). The procedure uses a device to disrupt certain nerves in the kidney arteries…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This study tested whether kidney transplant recipients with high blood pressure could better control their condition by monitoring their blood pressure at home, compared to standard clinic visits. The trial planned to enroll many participants but was stopped early after only 21 p…

This pilot study tested three common blood pressure medications—amlodipine, chlorthalidone, and losartan—in 36 young adults aged 18-40 with hypertension. Participants took the drugs at home and monitored their blood pressure regularly. The goal was to see which drug works best an…

This study tested a smartphone-based program to help stroke survivors with high blood pressure lower their risk of another stroke. The program involved tracking blood pressure and getting tailored reminders. The study was terminated early, so results are limited.

This study tested an experimental drug called REGN5381 in 34 adults with uncontrolled hypertension (high blood pressure despite taking one or more blood pressure medications). The drug is a monoclonal antibody designed to activate NPR1 receptors, which may help lower blood pressu…

This was a very early Phase 1 study testing a single injection of ART101 in people with high blood pressure. The trial was stopped after only 1 participant was enrolled, so no meaningful results are available. The goal was to check safety and how the drug moves through the body.

This study tested a drug called KBP-5074 in 652 adults with moderate-to-severe chronic kidney disease and high blood pressure that was not controlled by at least two other medications. Participants received either KBP-5074 or a placebo daily for up to 52 weeks to see if the drug …

Researchers are testing whether a plant-based diet can improve heart health in police officers who are overweight or have type 2 diabetes. The trial enrolls 20 officers from the Washington, D.C. police department and randomly assigns them to either follow a vegan diet with weekly…

This study aimed to compare two blood pressure medications—oral nifedipine (a pill) and intravenous labetalol (given through a vein)—for treating dangerously high blood pressure in women who have just given birth. The goal was to see which drug lowers blood pressure faster. Howev…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This study tested a new blood pressure device called ModPG3 on 7 newborns and infants to see if it meets international accuracy standards. The device uses two methods to measure blood pressure during cuff inflation and deflation. The trial was terminated early, so results are lim…

This study aimed to see if a new urine test can accurately tell whether people with type 2 diabetes are taking their medications as prescribed. Researchers planned to compare the urine test results with standard methods like questionnaires and pharmacy records in 90 participants.…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This study tested two new algorithms (SureBP and StepBP) in a blood pressure device to see if they measure blood pressure accurately in adults and children ages 3 and up. The goal was to check if the device meets international accuracy standards. The study was terminated early, s…

This study tested a non-invasive blood pressure monitor (CNAP) against the standard invasive method (using a needle in the artery) in 20 pregnant women with placenta accreta undergoing scheduled C-sections. The goal was to see if the gentler method gives equally accurate readings…

This study looked at whether blocking certain nerve signals can improve how the body uses insulin and reduce inflammation in people with obesity and high blood pressure. Ten participants took two drugs—moxonidine and amlodipine—to lower nerve activity. The goal was to see if this…