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Kidney nerve procedure tested for stubborn high blood pressure

NCT ID NCT05818813

Disease control Sponsor: Imperial College Healthcare NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at the long-term safety and effects of a procedure called renal denervation in 9 patients with resistant hypertension (high blood pressure that doesn't respond to multiple medications). The procedure uses a device to disrupt certain nerves in the kidney arteries, aiming to lower blood pressure. Researchers measured blood pressure and artery function before and 6 months after the procedure. The study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Renal denervation (a procedure using a device to disrupt nerves in the kidney arteries)
What this could lead to
If successful, this could point toward a long-term treatment option for patients with hard-to-control high blood pressure.
What could go wrong
This was a very small, terminated study with only 9 participants, so results are limited and may not apply to others. The procedure carries risks like artery damage or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

9 people

The number who actually took part.

Started

Apr 2021

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

People with resistant hypertension and no contraindication to renal denervation.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systolic blood pressure \>160mmHg despite 3 antihypertensive agents * eGFR \>45 Exclusion Criteria: * Secondary causes of hypertension * Prior renal artery intervention * Renal insufficiency * Significant stenotic valvular heart disease * Myocardial infarction, unstable angina or stroke within the preceding 6 months

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Conditions

The condition(s) this trial relates to.

hypertensive disorder resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • Hammersmith Hospital

    London, Middlesex, W12 0HS, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.