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Pill vs. IV: which works faster for postpartum hypertension?

NCT ID NCT05139238

Symptom relief Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to compare two blood pressure medications—oral nifedipine (a pill) and intravenous labetalol (given through a vein)—for treating dangerously high blood pressure in women who have just given birth. The goal was to see which drug lowers blood pressure faster. However, the trial was stopped early after only 2 participants enrolled, so no meaningful results were obtained.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nifedipine and labetalol
What this could lead to
If it worked, this could show that a simple pill works as well as an IV drug for treating severe postpartum high blood pressure, making treatment easier and faster.
What could go wrong
The trial was terminated after enrolling only 2 people, so no reliable conclusions can be drawn. It is too small to know which drug is better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

2 people

The number who actually took part.

Started

Jul 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Patients admitted to labor and delivery (L\&D) with blood pressure (BP) in severe range, defined as a systolic ≥160 mm Hg and/or diastolic ≥110 mm Hg * Postpartum, immediately to 6 weeks postpartum * With a prior diagnosis of chronic hypertension (not on medication) or hypertensive disorder of pregnancy Exclusion criteria * They may not have previously had exposure to either study medication within the previous 24-hour period. * Patients with a known atrial-ventricular heart block or moderate to severe bronchial asthma will be excluded, or other contraindication to receiving either study medication

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced Hypertensive Crisis hypertensive disorder malignant hypertension preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertensive emergency Postpartum preeclampsia Postpartum pregnancy-induced hypertension Pregnancy-induced hypertension in postpartum

Contacts and locations

Locations

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.