Glucose metabolism disease

This study tested whether a supplement called nicotinamide mononucleotide (NMN) can improve how the body handles sugar in people with prediabetes. Researchers gave NMN to 56 adults with higher-than-normal blood sugar and measured changes in insulin sensitivity and glucose toleran…

This study tests whether a structured Diabetes Healthcare Program can help adults with type 2 diabetes improve their blood sugar control and feel more confident managing their condition. Participants attend six biweekly training sessions covering diet, exercise, medication, and s…

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This Phase 3 trial tested a gene therapy called DTX401 in 49 people with glycogen storage disease type Ia (GSD Ia). The goal was to see if a single infusion could reduce or eliminate the need for frequent cornstarch doses to keep blood sugar stable. Participants were randomly ass…

This study tested a new oral drug called LY3549492 in 92 Japanese volunteers, some with type 2 diabetes and some healthy. The main goal was to check safety and how the body processes the drug. Participants took multiple doses over several weeks, and researchers monitored side eff…

This study checked the long-term safety of a one-time gene therapy (DTX401) in 12 adults with glycogen storage disease type Ia, a rare condition that causes dangerously low blood sugar. Researchers monitored side effects and how well the therapy helped control blood sugar levels …

This pilot study tested whether combining financial navigation (help with costs) and peer support (connecting with others) can help adults with diabetes better manage their condition. 61 participants were randomly assigned to receive either financial navigation alone or financial…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested a new weekly medicine called retatrutide in 537 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either the medicine or a placebo for about 11 months. The goal was to see if retatrutide safel…

This study looked at whether taking probiotics alongside regular diabetes medications can improve blood sugar, cholesterol, and inflammation in adults with type 2 diabetes. Researchers enrolled 77 people aged 35-65. The goal was to see if changing gut bacteria with probiotics cou…

This study tested whether personalized, automatic coaching messages based on continuous glucose monitor readings and mood assessments could help people with insulin-treated type 2 diabetes improve their blood sugar control. 46 adults participated over 12 weeks. The goal was to se…

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…

Researchers at Texas A&M University are studying whether small molecules in blood and skin fluid can predict how the body handles carbohydrates, protein, and fat from meals. The study involves 30 adults aged 50 to 75 who will eat different test meals and have their blood and skin…

This study tested whether a special fiber supplement changes intestinal gas production over 36 hours in 29 adults. Participants included lean healthy people and those with insulin resistance or prediabetes who were overweight. Researchers measured gas levels, energy use, and gut …

This completed pilot study looked at how the hormone glucagon affects brain function and insulin release, independent of its usual role in raising blood sugar. Fifteen healthy adults received a glucagon infusion on one day and a glucose infusion on another, while researchers meas…

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers tracked their blood sugar levels before, during, and after exercise to see how well the pumps handle physical activity. The goal was to learn …

This pilot study looked at how the hormone glucagon affects brain function and sugar use in 16 healthy adults. Participants received a gradually increasing dose of glucagon through an IV over three hours. The goal was to find the dose that changes blood sugar and other markers, h…