Gingivitis

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

Researchers are testing whether a toothpaste containing isopropyl methyl phenol reduces plaque buildup and gum bleeding better than a regular fluoride toothpaste. The 12-week study enrolls 120 Chinese adults with plaque-induced gingivitis. Dentists measure gum bleeding at weeks 2…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This study tests whether using an electric flosser along with a manual toothbrush and fluoride toothpaste reduces plaque and gum inflammation more than brushing alone. About 80 adults with mild gum disease will follow one of two routines for 30 days. Researchers will measure chan…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study is testing a mouth rinse made from stingless bee honey as a gentler alternative to standard chemical mouthwashes for gingivitis (gum inflammation). Researchers will develop the rinse, check its safety and germ-fighting power in the lab, then test it in 20 volunteers to…

This trial tests whether daily use of a botanical mouthwash for 14 days can improve gum health in healthy adults. Researchers compare two proprietary botanical blends, a combination of both, and a placebo rinse. They measure gum inflammation, dry mouth symptoms, and changes in th…

This trial compares two types of clear retainers worn after braces to see if the way they are made affects gum health. One retainer is created from a digital scan of the teeth, while the other uses a traditional plaster mold. About 52 people who recently finished braces will wear…

This study will test if a toothpaste with stannous fluoride can reduce bacteria on teeth, tongue, cheeks, and gums better than a regular toothpaste. About 100 adults with plaque and gingivitis will brush with one of the two toothpastes. The goal is to see which one controls bacte…

This study tests whether a new, chlorhexidine-free mouthwash can reduce plaque buildup, gum inflammation, and bad breath in children aged 12 to 17 who wear fixed metal braces. Participants rinse twice daily for 21 days alongside their usual brushing and flossing. The trial compar…

This trial compares a standardized siwak (chewing stick) oral hygiene program to conventional toothbrushing for improving gum health in young adults with gingivitis. Participants are dental students aged 18–24 who will follow either the siwak module or toothbrushing for 21 days. …

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This study looks at whether using a miswak stick—a natural teeth-cleaning twig—along with regular brushing can improve gum health in people with gingivitis. Researchers will measure markers of inflammation and oxidative stress in saliva and plaque. The goal is to see if this trad…

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This Phase 3 trial will test whether a toothpaste containing chitosan, a natural substance, can reduce plaque, gingivitis, and gum bleeding better than a standard fluoride toothpaste. About 90 adults aged 18-70 with good general health will brush with either the chitosan toothpas…

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This 6-week study tests whether an AI-based toothbrush (Xiaomi T501) with pressure sensing and coaching removes more plaque and reduces gum bleeding than a standard electric or manual toothbrush. Thirty-three adults with plaque-induced gingivitis will be randomly assigned to one …

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study will compare two types of tooth separators—elastomeric and nickel-titanium—used before placing orthodontic bands for braces. Thirty patients with crowded teeth will have one separator type on each side of their mouth. Researchers will measure how well they create space…

This study compares a homemade herbal mouthwash to chlorhexidine, the standard mouthwash for gingivitis. Gingivitis is a common gum disease caused by plaque buildup. The herbal option may have fewer side effects. The trial will include 12 adults with plaque-induced gingivitis and…

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study looks at whether children with molar-incisor hypomineralization (MIH) — a condition that weakens tooth enamel — have different levels of gum inflammation markers compared to children without MIH. Researchers will measure inflammatory substances in gum fluid from 76 chi…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study will test three ways to clean clear aligners: brushing with fluoride toothpaste, using chlorhexidine mouthwash, or using an oxygen-based cleanser. Twenty-one adults will try each method for one month to see how it affects bacteria and gum health. The goal is to find wh…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…