Diarrheal disease

This large study tests whether an oral cholera vaccine can also protect children aged 2 to 14 from infectious diarrhea caused by other germs. 6,000 healthy kids will get either the vaccine or a placebo. The goal is to see if the vaccine lowers the number of diarrhea cases, buildi…

This trial tests whether a daily fibre supplement, taken for 8 weeks, can improve gut health and ease symptoms like bloating, indigestion, and irregular bowel movements. Fifty adults who experience digestive discomfort will take the supplement each morning and answer questionnair…

This study tests whether Water Safety Plans—a set of management steps to keep drinking water safe from source to tap—can improve water quality and reduce diarrhea in rural Ghana. About 4,500 people from communities served by private water suppliers will be involved. Researchers w…

This study tests whether a daily supplement called CMTS4520, which combines dietary fiber and probiotics, can help adults with chronic diarrhoea. One hundred participants will receive either the supplement or a placebo for four weeks. Researchers will track changes in stool frequ…

This study tests whether giving probiotics (Bacillus clausii) to critically ill adults can reduce serious infections like pneumonia and bloodstream infections. One hundred ICU patients will receive either the probiotic or a sugar pill, and researchers will track infection rates a…

This trial tests a comprehensive school health program in 225 Zambian schools, involving trained teacher health workers, health rooms, and better sanitation. The program aims to improve children's health by providing health education, coordinating preventive care like deworming, …

This study tests whether replacing dirt floors with concrete in rural Bangladeshi homes can reduce infections in children. About 800 pregnant women and their future babies will take part, with children checked for parasites and diarrhea up to age 2. If concrete floors lower infec…

This study tests whether a probiotic supplement called iVS-1, containing Bifidobacterium adolescentis, can reduce moderate to severe digestive symptoms like bloating, gas, and belly pain. About 92 adults will take either the probiotic or a placebo for 6 weeks and report their sym…

This study tests whether a probiotic called Bifidobacterium longum BBH016 can improve lower gut symptoms like abdominal pain, diarrhea, and bloating. 88 adults with these symptoms but no constipation will take either the probiotic or a placebo capsule twice daily for 8 weeks. Res…

This study tests whether fecal microbiota transplantation (FMT) – giving healthy donor stool in capsules – can safely reduce chronic diarrhea in people with systemic sclerosis. Twenty adults with scleroderma and persistent diarrhea will receive either FMT or a placebo. The main g…

This pilot study will test a mobile app called ADEPT among 30 village doctors in Bangladesh. The app helps doctors decide when antibiotics are truly needed for children with diarrhea. The goal is to see if using the app reduces unnecessary antibiotic prescriptions, which is a maj…

This study looks at 200 people with ongoing stomach discomfort (functional dyspepsia) to find out how often they have small intestinal bacterial overgrowth (SIBO). Researchers will compare two methods—growing bacteria in a lab and DNA testing—to identify which germs are present. …

This study looks at whether using a UV light filter on private well water can lower the chance of stomach infections in children under 5. About 900 families in Pennsylvania and New Jersey will either get a working UV filter or a fake one. Researchers will track how often kids get…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …