Depressive disorder

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The study enrolled 47 adults who had responded well to…

This study looked at whether people with treatment-resistant depression who got better with electroconvulsive therapy (ECT) could switch to a less intense treatment called transcranial magnetic stimulation (TMS) to stay well. TMS is done in a clinic without anesthesia and has few…

This study tested the long-term safety of a drug called aticaprant when added to a standard antidepressant for adults with major depression. The trial planned to enroll 871 people but was terminated early, so the full safety and effectiveness data are not available. Researchers w…

Transgender and gender diverse adults smoke at higher rates than the general population, and stigma, discrimination, anxiety, and depression may make quitting harder. Researchers at Massachusetts General Hospital are adapting an existing smoking cessation program called QUIT, whi…

This phase II trial tests whether three low-dose ketamine infusions, given over consecutive days, can reduce depressive symptoms in patients who have been in the intensive care unit (ICU) for at least a week and show signs of clinical depression. Participants receive either ketam…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tests whether a breathing-based meditation practice called SKY can reduce symptoms of depression and anxiety in adolescents aged 16 to 24. Participants with mild-to-moderate depression will practice the breathing techniques for 8 weeks, while researchers track mood, st…

This study aimed to see if a smartphone app called IONA Mind could help treat depression in people who have had head and neck cancer. Participants would use the app for 6 weeks and fill out surveys. However, the trial was terminated early after enrolling only 1 person, so no mean…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This study tests whether placebo pills taken knowingly — called open-label placebo — can reduce depression symptoms in unmedicated teens aged 13–18 with mild to moderate depression. Participants take placebo pills for two weeks while researchers use brain scans to see if the trea…

This study tested a new drug called REL-1017 as an extra treatment for adults with major depression who didn't get enough help from standard antidepressants. The trial was stopped early and included only 27 participants. The main goal was to see if the drug could reduce depressio…

This study tested a new drug called REL-1017 (esmethadone) as an add-on treatment for people with major depression who weren't helped enough by their current antidepressant. The trial was a Phase 3, double-blind, placebo-controlled study with 236 participants. However, the study …

This study tested an experimental drug called MIJ821, given as an IV infusion, to see if it could quickly reduce depression symptoms in people with major depressive disorder who also have active suicidal thoughts. About 199 adults aged 18 to 65 took part, receiving either MIJ821 …

This study followed 26 people with major depressive disorder for one year after they received a single dose of psilocybin or a niacin control. Researchers used web surveys and phone interviews to track depression symptoms over time. The study was terminated early, so results are …

This study tested whether a mindfulness program (including meditation, body scans, and gentle yoga) could help people with implanted heart devices like ICDs or pacemakers feel less anxious, stressed, and depressed. The study planned to enroll 34 adults who had recently received s…

This study tested whether a digital platform could improve collaborative care for depression in cancer patients. About 300 adults receiving cancer treatment with significant depression symptoms were enrolled. The platform aimed to help care managers track symptoms and coordinate …

This study aimed to see if a telephone-supported self-help program called Bounce Back could help people with mild to moderate depression. Participants used cognitive behavioral therapy (CBT) materials at home with coaching over the phone. The study was stopped early and only incl…

This small pilot study tested a noninvasive brain stimulation technique called tDCS in 5 adults with major depression that hadn't improved after at least 3 antidepressant trials. Participants received up to 20 sessions of higher-than-usual electrical current over 4 to 6 weeks. Th…

This study tested whether adding aticaprant to standard antidepressants could help people with major depression who still feel no pleasure (anhedonia). The trial was stopped early after enrolling only 101 participants. No results are available, so it is unknown if aticaprant work…

This study looked at whether a group therapy program combining psychotherapy and physiotherapy could help women with long-lasting pelvic or belly pain. Only 8 women took part, and the study was stopped early. Researchers measured changes in pain impact, daily activities, and emot…

This study looked at the long-term safety and symptom relief of an experimental drug called AXS-05 in 181 adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants took the drug and were monitored for side effects and mood ch…

This study tested the drug tianeptine in 38 adults with major depression that did not improve after at least two other treatments. Participants took tianeptine three times a day for 8 weeks. The goal was to see if it reduced depression symptoms and changed how the brain processes…

This study aimed to see if adding Problem Solving Therapy to standard suicide safety planning could reduce suicidal thoughts in older veterans (age 55+) with depression, anxiety, or PTSD. The trial planned to enroll 117 veterans but was terminated early. The approach focused on t…

This study tested an online support group for young adults (ages 18-39) who had cancer treatment and were feeling anxious or distressed during the COVID-19 pandemic. The goal was to see if teaching healthy coping skills through a virtual group could improve their mood and confide…

This study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with other treatments. Six adults with major depression or bipolar disorder took part. The goal was to see if practicing new b…

This study tested a new medicine called fosigotifator for adults with major depressive disorder. The goal was to see if it is safe and helps with depression symptoms. About 20 people were enrolled before the study was stopped early. Participants took either the drug or a placebo,…

This pilot study tested whether using brain scans to personalize magnetic stimulation (rTMS) could improve treatment for people with depression that hasn't responded to medication. 27 participants received either personalized rTMS, standard rTMS, or a different type of brain stim…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This trial tests whether a 12-minute educational video, shown at hospital discharge, improves new mothers' knowledge of warning signs for severe postpartum complications like hemorrhage, infection, and high blood pressure. Participants – who are Black, Latinx, multiracial, Medica…

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This pilot study tested a decision aid designed to help older adults with early dementia or depression think about safer ways to store firearms at home. Only 5 people took part, and the study was ended early. The goal was to see if the tool was practical and acceptable, and wheth…

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This study aimed to find brain and movement markers in people with a type of depression that doesn't respond to standard antidepressants, called anhedonic depression. Researchers measured brain waves (P300), walking speed, and hand movements in 36 participants. The goal was to id…

This study tested a care coordination and motivational interviewing program for women who recently had a preterm birth. The goal was to see if the program was feasible and acceptable to participants. Only 13 women enrolled before the study was terminated, so the findings are very…

This study looked at how allopregnanolone, a natural brain chemical, affects mood and thinking in perimenopausal women with depression. Researchers gave participants either the drug brexanolone (a form of allopregnanolone) or a placebo to see how it changed their tendency to rumi…

This study aimed to see if giving patients extra encouragement before and after esketamine treatment could improve their depression symptoms. Researchers planned to compare a group that received a positive presentation and follow-up session with a group that did not. However, the…

This study looked at whether teens ages 14 to 21 with mild depression or anxiety would use a website to write articles for other teens. The goal was to see if this approach was practical and acceptable. The study was stopped early, and only 12 people took part.

This study looked at why some people have more suicidal thoughts when they start or switch antidepressants. 38 adults with major depression used a smartphone app to rate their dark thoughts and mood daily for 30 days. The goal was to better understand and monitor this early risk …

This study tested whether a program called Nurse Family Partnership (NFP) could help pregnant women who already had a child. The program involved regular visits from a nurse to support the mother's health, pregnancy, and child development. The trial enrolled 23 women and aimed to…