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Can ancient breathing techniques rewire the depressed teen brain?

NCT ID NCT05388110

Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a breathing-based meditation practice called SKY can reduce symptoms of depression and anxiety in adolescents aged 16 to 24. Participants with mild-to-moderate depression will practice the breathing techniques for 8 weeks, while researchers track mood, stress hormones, heart rate, and brain scans. The goal is to see if this practice changes brain activity in ways that ease depression, offering a potential new treatment option for young people.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
SKY Breath Intervention (Sudarshan Kriya Yoga), a sequence of specific breathing techniques
What this could lead to
If effective, this could offer a drug-free, low-cost option to ease depression and anxiety in adolescents.
What could go wrong
This is a small early-stage study, so results may not apply broadly. The breathing practice may not work for everyone, and the brain changes are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

14 people

The number who actually took part.

Started

Apr 2022

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Depressed adolescents and healthy controls ages 16-24 years old

Ages

16 to 24 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adolescent participants ages 16-24 yrs old (NIH defines adolescents as up through age 24 years old) * mild-to-moderate depression with the BDI-II score greater than or equal to 14 (Smarr and Keefer 2011) * technologically able (Zoom); * nonpractitioners of daily meditation/breath-work. Exclusion Criteria: * pregnant or lactating females * metal implants unsafe for MRI * current or lifetime diagnosis of schizophrenia, schizoaffective, bipolar on lithium, or seizure disorders * recent surgical patient (within 6 months) * substance use disorder within the last 1 year * history of significant medical conditions (e.g. traumatic brain injury) * suicidal ideation (SI) with intent and/or plan to harm self (SI without intent and/or plan to harm self will be allowed to enter the study)

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety disorders Depression

Contacts and locations

Locations

  • University of California, San Francisco

    San Francisco, California, 94143, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.