Coronary aneurysm

This trial tests whether a new device called OmniHeart 4.0 can safely support the heart during high-risk angioplasty, compared to the standard ECMO machine. About 254 patients will be randomly assigned to receive either the OmniHeart or ECMO. Researchers will track major heart an…

This study tests whether the antibiotic doxycycline can prevent or slow the enlargement of heart arteries in children with Kawasaki disease. About 26 children with already enlarged coronary arteries will receive doxycycline for three weeks. The goal is to see if the drug blocks a…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This study tests whether using intravascular ultrasound (IVUS) to guide a specific stenting technique (DK crush) leads to fewer heart problems than standard angiography guidance. About 556 adults with complex coronary bifurcation lesions will be randomly assigned to one of the tw…

This study compares a new, smaller heart pump called NyokAssist to a standard balloon pump in people having high-risk heart procedures to open blocked arteries. The goal is to see if the new pump reduces serious heart and brain complications. About 236 adults will take part in th…

This study planned to test whether taking two blood vessel-relaxing drugs (isosorbide mononitrate and amlodipine) for 24 weeks after coronary bypass surgery could prevent failure of the radial artery graft. The trial was withdrawn before enrolling any participants, so no data wer…

This study looks at whether certain blood markers can identify people without significant coronary artery disease, avoiding the need for more invasive tests. Researchers will enroll 1000 adults referred for a CT scan of the heart. The goal is to see if these biomarkers can accura…

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This study tests whether a small shot of nitroglycerin under the skin can widen the wrist artery, making it easier for doctors to insert a tube for heart procedures. It involves 1,400 adults with coronary artery disease scheduled for heart catheterization. The goal is to reduce t…

This study tests two improvements for heart catheterization done through a small artery in the wrist. First, it checks if a special patch can stop bleeding faster. Second, it sees if using ultrasound to guide the needle makes the procedure more successful. About 480 adults needin…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study tests a new sensor worn on the skin that measures lactate levels without needles. It involves 20 adults recovering from heart bypass or valve surgery. The goal is to see if the sensor works as well as standard blood tests, which could make monitoring more comfortable a…