Corneal dystrophy
MONDO:0018102The term corneal dystrophy embraces a heterogeneous group of bilateral genetically determined non-inflammatory corneal diseases that are usually restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value.
Also known as: corneal dystrophy, corneal dystrophy (disease)
66 clinical trials for this condition and its sub-types, 6 tagged with Corneal dystrophy itself.
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Sub-types of Corneal dystrophy
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Corneal endothelial dystrophy 5 trials · 36 incl. sub-types
4 sub-types
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Posterior corneal dystrophy 0 trials · 34 incl. sub-types
6 sub-types
- Fuchs' endothelial dystrophy 33 trials Sub-types →
- Congenital hereditary endothelial dystrophy of cornea 2 trials
- Posterior polymorphous corneal dystrophy 1 trial Sub-types →
- X-linked endothelial corneal dystrophy 0 trials
- Central cloudy dystrophy of François 0 trials
- Congenital hereditary endothelial dystrophy type I 0 trials
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Stromal corneal dystrophy 2 trials · 16 incl. sub-types
10 sub-types
- Macular corneal dystrophy 13 trials
- Fleck corneal dystrophy 1 trial
- Schnyder corneal dystrophy 0 trials
- Central cloudy dystrophy of François 0 trials
- Congenital stromal corneal dystrophy 0 trials
- Granular corneal dystrophy type I 0 trials
- Granular corneal dystrophy type II 0 trials
- Lattice corneal dystrophy 0 trials Sub-types →
- Posterior amorphous corneal dystrophy 0 trials
- Pre-descemet corneal dystrophy 0 trials
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Superficial corneal dystrophy 0 trials · 7 incl. sub-types
12 sub-types
- Corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome 4 trials
- Epithelial basement membrane dystrophy 2 trials
- Thiel-Behnke corneal dystrophy 1 trial
- Grayson-Wilbrandt corneal dystrophy 0 trials
- Lisch epithelial corneal dystrophy 0 trials
- Meesmann corneal dystrophy 0 trials Sub-types →
- Reis-Bucklers corneal dystrophy 0 trials
- Epithelial recurrent erosion dystrophy 0 trials
- Gelatinous drop-like corneal dystrophy 0 trials
- Hereditary benign intraepithelial dyskeratosis 0 trials
- Honey-droplet corneal dystrophy 0 trials
- Subepithelial mucinous corneal dystrophy 0 trials
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Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types
8 sub-types
- Epithelial basement membrane dystrophy 2 trials
- Thiel-Behnke corneal dystrophy 1 trial
- Reis-Bucklers corneal dystrophy 0 trials
- Corneal dystrophy, lattice type 3A 0 trials
- Corneal granular dystrophy 0 trials
- Granular corneal dystrophy type I 0 trials
- Granular corneal dystrophy type II 0 trials
- Lattice corneal dystrophy type I 0 trials
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Chandler syndrome 2 trials
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Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types
5 sub-types
- Epithelial basement membrane dystrophy 2 trials
- Lisch epithelial corneal dystrophy 0 trials
- Meesmann corneal dystrophy 0 trials Sub-types →
- Gelatinous drop-like corneal dystrophy 0 trials
- Subepithelial mucinous corneal dystrophy 0 trials
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Finnish type amyloidosis 0 trials
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Judge Misch wright syndrome 0 trials
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Autosomal dominant keratitis 0 trials
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Band keratopathy 0 trials
Most studied deeper sub-types
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Cornea transplant showdown: which surgery gives sharper sight?
Disease control OngoingThis study compares two types of cornea transplant surgery—DSAEK and DMEK—in 220 adults with corneal swelling or Fuchs' dystrophy. The goal is to see which procedure leads to better vision and patient satisfaction one year after surgery. Participants will be randomly assigned to …
Sponsor: University Hospital, Antwerp • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Experimental drug combo tested for rare, deadly castleman disease
Disease control OngoingThis study looks at a rare disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers are testing several drug combinations, including chemotherapy and antivirals, to see if they can control the disease. The study also tracks how the dis…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Rapamycin drug tested for rare castleman disease
Disease control OngoingThis phase 2 study tests the drug sirolimus (rapamycin) in 7 people with idiopathic multicentric Castleman disease who have not improved with standard therapy. The goal is to see if sirolimus can improve symptoms like fatigue, fever, and night sweats, and shrink enlarged lymph no…
Phase 2 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Eye transplant showdown: which surgery saves sight best?
Disease control OngoingThis study compares two types of corneal transplant surgery (UT-DSAEK and DMEK) in 160 people with Fuchs dystrophy, a condition that clouds the cornea. It also tests whether a drug called rho-kinase inhibitor can reduce loss of important eye cells after surgery. The goal is to fi…
Phase 3 • Sponsor: Stanford University • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Can a donor lens implant restore clarity to clouded corneas?
Disease control By invitation onlyThis trial investigates whether implanting a fresh corneal lenticule — a thin layer of donor cornea taken from myopic patients — can improve transparency and vision in people with macular corneal dystrophy, a condition that clouds the cornea. Using a femtosecond laser, surgeons r…
Sponsor: Eye Hospital Pristina Kosovo • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Lab-Grown eye cells injected to reverse corneal blindness
Disease control OngoingThis early-stage trial tests whether injecting cultured corneal endothelial cells into the eye can repair damaged corneas and improve vision. Twelve adults with corneal swelling and poor eyesight received a single injection of donor cells grown in a lab. The goal is to see if the…
Phase 1 • Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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Eye drops may shield the cornea after cataract surgery
Prevention By invitation onlyResearchers are testing whether netarsudil eye drops can protect the cornea in people with Fuchs endothelial corneal dystrophy and glaucoma who have cataract surgery. The study enrolls 50 adults aged 40 to 90. Participants use either netarsudil or a placebo drop daily for four we…
Sponsor: University Hospital Dubrava • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Contact lens stress test for fuchs dystrophy eyes
Knowledge-focused CancelledThis study aimed to compare how corneas with Fuchs endothelial corneal dystrophy (FECD) and healthy corneas swell and recover after wearing a contact lens for three hours. Researchers planned to measure corneal thickness before and after the lens was removed, tracking swelling an…
Phase 1/2 • Sponsor: Massachusetts Eye and Ear Infirmary • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Does donor diabetes impact corneal transplant outcomes?
Knowledge-focused By invitation onlyThis study looks at whether corneas from donors with diabetes work as well as those from donors without diabetes after a specific type of corneal transplant called DMEK. Researchers will track 570 participants for 5 years to measure cell loss and overall transplant success. The g…
Sponsor: Case Western Reserve University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC