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Does donor diabetes impact corneal transplant outcomes?

NCT ID NCT07217249

Knowledge-focused Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether corneas from donors with diabetes work as well as those from donors without diabetes after a specific type of corneal transplant called DMEK. Researchers will track 570 participants for 5 years to measure cell loss and overall transplant success. The goal is to better understand how donor health affects long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 570 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 93 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Willing to return to the study site for follow up at 3 and 5 years after a Descemet membrane endothelial keratoplasty procedure * Fluent in English or Spanish * Willing to have fingerstick blood sample collected to determine HbA1c level * Participated and completed 12-month follow-up in the DEKS study for one or both eyes or a DEKS participant that had a study eye regraft prior to the 12-month visit. Exclusion Criteria: * Lack cognitive capacity such that consent could not be provided.

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Conditions

The condition(s) this trial relates to.

corneal edema Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corneal endothelial decompensation Fuchs endothelial corneal dystrophy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Associated Eye Care

    Stillwater, Minnesota, 55082, United States

  • Georgia Eye Partners

    Atlanta, Georgia, 30189, United States

  • Kansas City Eye Clinic

    Overland Park, Kansas, 66204, United States

  • Legacy Devers Eye Institute

    Portland, Oregon, 97210, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mid-Atlantic Cornea Consultants

    Baltimore, Maryland, 21204, United States

  • Minnesota Eye Consultants

    Bloomington, Minnesota, 55431, United States

  • Moyes Eye Center

    Kansas City, Missouri, 64154, United States

  • Ophthalmic Partners

    Bala-Cynwyd, Pennsylvania, 19004, United States

  • Price Vision Group

    Indianapolis, Indiana, 46260, United States

  • The Wilmer Eye Institute/Johns Hopkins

    Baltimore, Maryland, 21287, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Michigan/Kellogg Eye Center

    Ann Arbor, Michigan, 48105, United States

  • Verdier Eye Center

    Grand Rapids, Michigan, 49546, United States

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