Corneal dystrophy
MONDO:0018102The term corneal dystrophy embraces a heterogeneous group of bilateral genetically determined non-inflammatory corneal diseases that are usually restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value.
Also known as: corneal dystrophy, corneal dystrophy (disease)
66 clinical trials for this condition and its sub-types, 6 tagged with Corneal dystrophy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Corneal dystrophy
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Corneal endothelial dystrophy 5 trials · 36 incl. sub-types
4 sub-types
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Posterior corneal dystrophy 0 trials · 34 incl. sub-types
6 sub-types
- Fuchs' endothelial dystrophy 33 trials Sub-types →
- Congenital hereditary endothelial dystrophy of cornea 2 trials
- Posterior polymorphous corneal dystrophy 1 trial Sub-types →
- X-linked endothelial corneal dystrophy 0 trials
- Central cloudy dystrophy of François 0 trials
- Congenital hereditary endothelial dystrophy type I 0 trials
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Stromal corneal dystrophy 2 trials · 16 incl. sub-types
10 sub-types
- Macular corneal dystrophy 13 trials
- Fleck corneal dystrophy 1 trial
- Schnyder corneal dystrophy 0 trials
- Central cloudy dystrophy of François 0 trials
- Congenital stromal corneal dystrophy 0 trials
- Granular corneal dystrophy type I 0 trials
- Granular corneal dystrophy type II 0 trials
- Lattice corneal dystrophy 0 trials Sub-types →
- Posterior amorphous corneal dystrophy 0 trials
- Pre-descemet corneal dystrophy 0 trials
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Superficial corneal dystrophy 0 trials · 7 incl. sub-types
12 sub-types
- Corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome 4 trials
- Epithelial basement membrane dystrophy 2 trials
- Thiel-Behnke corneal dystrophy 1 trial
- Grayson-Wilbrandt corneal dystrophy 0 trials
- Lisch epithelial corneal dystrophy 0 trials
- Meesmann corneal dystrophy 0 trials Sub-types →
- Reis-Bucklers corneal dystrophy 0 trials
- Epithelial recurrent erosion dystrophy 0 trials
- Gelatinous drop-like corneal dystrophy 0 trials
- Hereditary benign intraepithelial dyskeratosis 0 trials
- Honey-droplet corneal dystrophy 0 trials
- Subepithelial mucinous corneal dystrophy 0 trials
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Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types
8 sub-types
- Epithelial basement membrane dystrophy 2 trials
- Thiel-Behnke corneal dystrophy 1 trial
- Reis-Bucklers corneal dystrophy 0 trials
- Corneal dystrophy, lattice type 3A 0 trials
- Corneal granular dystrophy 0 trials
- Granular corneal dystrophy type I 0 trials
- Granular corneal dystrophy type II 0 trials
- Lattice corneal dystrophy type I 0 trials
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Chandler syndrome 2 trials
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Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types
5 sub-types
- Epithelial basement membrane dystrophy 2 trials
- Lisch epithelial corneal dystrophy 0 trials
- Meesmann corneal dystrophy 0 trials Sub-types →
- Gelatinous drop-like corneal dystrophy 0 trials
- Subepithelial mucinous corneal dystrophy 0 trials
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Finnish type amyloidosis 0 trials
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Judge Misch wright syndrome 0 trials
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Autosomal dominant keratitis 0 trials
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Band keratopathy 0 trials
Most studied deeper sub-types
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Can a single Gene-Editing injection stop a blinding corneal disease?
Cure Not yet recruitingThis trial tests a single injection of GEB-101, a gene-editing treatment, directly into the cornea of people with TGFBI-related corneal dystrophy, a hereditary condition that causes progressive vision loss. The study aims to see if the treatment is safe and whether it can slow or…
Phase 1/2 • Sponsor: GenEditBio Limited • Aim: Cure
Last updated Sep 12, 2026 00:00 UTC
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One shot to see clearly: cell therapy takes on corneal edema
Cure Not yet recruitingThis phase 2 trial tests whether a single injection of EO2002, made from magnetic human corneal endothelial cells, can safely improve vision in people with corneal edema caused by endothelial dysfunction. Participants receive either a low or high dose of cells or a placebo inject…
Phase 2 • Sponsor: Emmecell • Aim: Cure
Last updated Jul 31, 2026 00:00 UTC
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Laser vs. scraping: which eye treatment wins for corneal dystrophy?
Disease control Not yet recruitingThis trial compares two surgical techniques for treating corneal basement membrane dystrophy, a condition that causes blurred vision and painful eye erosions. One method is manual scraping of the damaged corneal layer; the other uses a laser to remove it. The study aims to find w…
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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No-Stitch eye gel could heal corneal wounds faster
Disease control Not yet recruitingThis study will test a special gel that can be injected into the eye to seal wounds on the cornea (the clear front part of the eye) without needing stitches. The gel turns from liquid to solid inside the eye and helps the cornea heal naturally. About 30 adults with certain types …
Sponsor: Suxia Li • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Could a supplement boost prostate cancer treatment?
Disease control Not yet recruitingThis early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 w…
Early phase 1 • Sponsor: Shanghai Changzheng Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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New eye test spots brain fog after cornea surgery
Diagnosis Not yet recruitingThis study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…
Sponsor: The S.N. Fyodorov Eye Microsurgery State Institution • Aim: Diagnosis
Last updated Jun 27, 2026 09:07 UTC
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New lens aims to sharpen sight after dual eye surgery
Symptom relief Not yet recruitingThis study will test a new type of artificial lens, called the PureSee IOL, in 10 people who need surgery for both cataracts and a cornea condition called Fuchs dystrophy. The goal is to see if this lens helps patients see well at different distances and reduces their need for gl…
Sponsor: Universitair Ziekenhuis Brussel • Aim: Symptom relief
Last updated Aug 27, 2026 00:00 UTC
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Fuchs dystrophy and cataract surgery: does the cornea behave differently?
Knowledge-focused Not yet recruitingThis observational study compares corneal thickness six weeks after routine cataract surgery in people with Fuchs endothelial corneal dystrophy (FECD) versus those without the condition. Researchers aim to see whether FECD eyes swell more or recover differently after surgery. Par…
Sponsor: Vienna Hospital Association • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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New test may predict prostate cancer treatment success
Knowledge-focused Not yet recruitingThis study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will track 50 newly diagnosed patients to see how different gene patterns affect treatment resp…
Sponsor: Anhui Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC