Could a supplement boost prostate cancer treatment?
NCT ID NCT07389174
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 weeks. The main goal is to check for side effects, but researchers will also look at PSA levels and how long it takes for the cancer to become resistant to treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- LC-K76 (a dietary supplement)
- What this could lead to
- If it works, this could point toward a way to improve standard hormone therapy for metastatic prostate cancer.
- What could go wrong
- This is a very early, small trial (40 people) focused on safety, not proof of effectiveness. The supplement may not provide any added benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male, aged ≥ 18 years. 2. Histologically or cytologically confirmed newly diagnosed metastatic hormone-sensitive prostate adenocarcinoma, without small cell carcinoma or small cell components. 3. Presence of at least one bone metastasis or visceral metastasis (excluding lymph nodes) detected by systemic imaging (CT/MRI). 4. No prior treatment for prostate cancer before enrollment (including but not limited to radical surgery, radiotherapy, endocrine therapy, or chemotherapy). 5. No history of allergy to dandelion or dandelion products. 6. ECOG performance status ≤ 2. 7. Plan to receive and maintain Androgen Deprivation Therapy (ADT) combined with an androgen receptor antagonist (e.g., enzalutamide, apalutamide, darolutamide), abiraterone acetate, or other drugs inhibiting testosterone synthesis during the study period. 8. Subjects are able to comply with oral LC-K76 capsule administration and adhere to study requirements throughout the study Exclusion Criteria: 1. Lack of pathological evidence for prostate cancer diagnosis. 2. Prior receipt of any treatment modality for prostate cancer. 3. Patients with other primary malignant tumors that were progressive or required active treatment within the past 3 years. 4. Patients with diabetes requiring continuous insulin therapy or poorly controlled diabetes. 5. Known or suspected central nervous system metastases or active leptomeningeal disease. 6. Significant abnormalities in bone marrow, coagulation, renal, and hepatic function, defined as laboratory values at randomization: Hemoglobin \< 90 g/L, Neutrophils \< 1.5 × 10$\^9$/L, Platelets \< 75 × 10$\^9$/L, ALT \> 2.5 × ULN, AST \> 2.5 × ULN, or Serum Total Bilirubin \> 1.5 × ULN; eGFR \< 60 mL/min/1.73m$\^2$. 7. Any severe disease affecting cardiopulmonary function or high-risk conditions. 8. History of severe drug allergies. 9. Presence of factors interfering with swallowing, chronic diarrhea, intestinal obstruction, or other factors affecting drug intake and absorption. 10. Concurrent psychiatric illness or neurological symptoms judged to make participation difficult. 11. Any condition that, in the judgment of the investigator, poses a severe safety risk to the patient, may confound study results, or may affect the patient's ability to complete the study (e.g., poorly controlled hypertension, severe diabetes, neurological or psychiatric disorders), or any other relevant conditions. 12. Concurrent participation in other clinical trials or use of other investigational drugs. 13. Refusal or inability to sign the informed consent form.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Changzheng hospital
Shanghai, Shanghai Municipality, 201109, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- A proactive care plan may help men with prostate cancer live better
- Can a simple blood test outsmart prostate cancer?
- Half the dose, same hope? trial tests cutting hormone therapy in prostate cancer
- A sharper eye on prostate cancer: could new imaging spare healthy tissue?