Shanghai Changzheng Hospital

This study is testing whether an antibiotic called rifaximin can help people with metabolic-associated fatty liver disease (MAFLD). About 40 adults will take the drug for 24 weeks, and if needed, up to 48 weeks. The main goal is to see if it safely reduces liver fat measured by M…

This early-phase study tests a new mRNA drug called MTS109 in 15 people with moderate to severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and side effects, not to cure the disease. Participants receive the drug by IV and are monitored closel…

This study tests a combination of two approved drugs, anlotinib and sintilimab, as a first treatment for people with advanced colorectal cancer that has spread but not to the liver. The goal is to shrink or control the cancer while avoiding standard chemotherapy. The trial enroll…

This study tests a drug called IBI311 in 50 adults with inactive moderate-to-severe thyroid eye disease, a condition that can cause bulging eyes and double vision. The drug works by blocking a specific receptor to reduce swelling and tissue growth behind the eyes. Researchers wil…

This study tests whether a single injection of human induced stem cells (hiSCs) into the knee is safe and can help relieve symptoms of rheumatoid arthritis. Fifteen adults with active knee arthritis will receive the injection and be monitored for side effects and improvements in …

This study tests two treatments for active moderate to severe thyroid eye disease (TAO), a condition that can cause bulging eyes, double vision, and even blindness. One group gets standard hormone therapy, the other gets IBI311, a newer targeted drug. Researchers will compare how…

This study tests a drug called tetuzumab (IBI311) in 96 adults with moderate-to-severe active thyroid eye disease (TAO) who did not respond well to steroids. The drug blocks a protein that fuels inflammation and tissue swelling behind the eyes. The main goals are to see if it red…

This early-stage study tests whether the antibiotic rifaximin-α can reduce liver fat in people with metabolic fatty liver disease (MASLD). About 60 adults will take either the drug or just follow lifestyle advice for 24 weeks, then be monitored for another 24 weeks. The goal is t…

This study looks at whether giving pancreatic enzymes to people with chronic pancreatitis and poor digestion can improve blood sugar control. Researchers will track 80 adults over time to see changes in glucose levels and digestive function. The goal is to better understand how t…

This study follows over 4,000 adults from Shanghai communities to track how heart, kidney, and metabolic diseases develop and change over time. Participants were first checked between 2016-2017 and will be re-assessed through 2035. The goal is to understand risk factors and impro…

This study looks at whether the amount of iron in tears is linked to how severe dry eye disease is. Researchers will compare tear samples from 52 people with dry eyes and healthy eyes. The goal is to find a new way to diagnose and understand dry eye better.

This study uses a non-invasive eye-tracking test to understand how Thyroid-Associated Ophthalmopathy (TAO) affects eye movement and visual attention. Researchers will compare 100 participants, including both patients and healthy volunteers, to measure differences in gaze stabilit…