Complex regional pain syndrome type 1
MONDO:0011441Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.
Also known as: Algodystrophy, CRPS I, CRPS1, Complex regional pain syndrome I, RND, RSDS, complex regional pain syndrome type 1, reflex neurovascular dystrophy
152 clinical trials for this condition and its sub-types, 31 tagged with Complex regional pain syndrome type 1 itself.
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Vitamin c may ward off Post-Surgery pain syndrome
Prevention CompletedThis study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduce…
Phase 3 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Prevention
Last updated Jun 27, 2026 13:06 UTC
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Vitamin c shows promise in preventing Post-Fracture pain syndrome
Prevention CompletedThis study looked at whether taking vitamin C can prevent Complex Regional Pain Syndrome (CRPS), a painful condition that can develop after a wrist fracture. Researchers enrolled 220 adults with specific types of wrist fractures and gave them vitamin C to see if it reduced their …
Phase 4 • Sponsor: Damascus University • Aim: Prevention
Last updated Jun 27, 2026 11:02 UTC
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Can a skin injection of ketamine and lidocaine tame CRPS pain?
Symptom relief CompletedThis trial tests whether injecting a mix of ketamine and lidocaine into the skin, a technique called mesotherapy, can reduce neuropathic pain in people with complex regional pain syndrome type 1 (CRPS1). Participants receive four sessions of either the drug mixture or lidocaine a…
Phase 2/3 • Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Aug 12, 2026 00:00 UTC
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Spinal implant plus exercise may ease back pain after failed surgery
Symptom relief CompletedThis study investigates whether combining spinal cord stimulation with a specific exercise program can reduce pain and improve quality of life in people with persistent back pain after surgery (failed back surgery syndrome). Participants will be randomly assigned to receive eithe…
Sponsor: Fundación Universidad Católica de Valencia San Vicente Mártir • Aim: Symptom relief
Last updated Jul 09, 2026 00:00 UTC
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Virtual reality offers new hope for chronic arm pain sufferers
Symptom relief CompletedThis study looked at whether adding immersive virtual reality (VR) to standard rehab helps people with long-term arm pain (Complex Regional Pain Syndrome) use their arm better. 13 adults took part, using VR during occupational therapy sessions. The goal was to see if VR could imp…
Sponsor: University Hospital, Angers • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Nerve block combo may ease chronic pain condition
Symptom relief CompletedThis completed study looked at whether giving a continuous nerve block along with intensive physical and occupational therapy can improve recovery in people with Complex Regional Pain Syndrome type 1 (CRPS 1). The study enrolled 30 patients and followed them for up to a year. The…
Sponsor: Pôle Saint Hélier • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Virtual reality boosts brain training to soothe stroke pain
Symptom relief CompletedThis study tested whether adding virtual reality to motor imagery exercises (mentally practicing movements) can better reduce pain and disability in people with post-stroke shoulder hand syndrome. Forty adults aged 40-70 who had a stroke at least 3 months ago took part. The main …
Sponsor: Green International University • Aim: Symptom relief
Last updated Jun 27, 2026 12:38 UTC
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Magnetic device shows promise for chronic foot pain
Symptom relief CompletedThis study tested whether a device that delivers pulsed electromagnetic fields (I-ONE) could help people with complex regional pain syndrome (CRPS) of the foot or ankle. Twenty-eight participants received the device therapy plus standard rehabilitation. Researchers measured pain,…
Sponsor: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Electric bike training may soothe Post-Stroke arm pain
Symptom relief CompletedThis study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…
Sponsor: Zeynep Nur Köseoğlu • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Mirror trick may ease Post-Stroke pain
Symptom relief CompletedThis study tested whether mirror therapy can reduce pain and improve movement in stroke patients who also have complex regional pain syndrome (CRPS). Forty adults who had a stroke within the past year and were diagnosed with CRPS took part. They received either real mirror therap…
Sponsor: Başakşehir Çam & Sakura City Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Can special goggles reduce CRPS pain? new study tests prism therapy
Symptom relief CompletedThis study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…
Sponsor: Ankara Etlik City Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Can mirror therapy ease chronic pain better than standard rehab?
Symptom relief CompletedThis study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…
Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Surgery offers new hope for chronic pain sufferers
Symptom relief CompletedThis study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery,…
Sponsor: Jitka Fricova • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Simple taping and needling combo eases Stroke-Related arm pain
Symptom relief CompletedThis study looked at whether kinesio taping (a special stretchy tape) plus dry needling (thin needles into tight muscle spots) can help people with shoulder-hand syndrome after a stroke. 84 patients were split into three groups: taping alone, needling alone, or both together, all…
Sponsor: Handan Central Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Wearable sensors reveal hidden body changes during nerve stimulation for CRPS pain
Knowledge-focused CompletedThis study looked at 24 people with Complex Regional Pain Syndrome (CRPS) type I in their legs who already use a device that stimulates nerves near the spine (dorsal root ganglion stimulation) to control pain. Researchers used special wearable sensors to track things like heart r…
Sponsor: AZ Delta • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC