Chronic apical periodontitis

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to se…

This study tests two different root canal filling pastes (iRoot SP and nRoot SP) in 160 adults with chronic tooth infection. The goal is to see which paste better heals the infection and relieves symptoms like pain and swelling. Participants will be followed for up to 2 years aft…

This study tests whether simvastatin, a common cholesterol drug, can fight infection and reduce inflammation when placed inside a tooth during root canal retreatment. Fifty-four adults with a single-rooted tooth that had a failed root canal and a small area of bone loss around th…

This study tests whether using an 810 nm diode laser during root canal retreatment helps the bone around the tooth heal better. Forty adults with a failed root canal and a visible infection will receive standard retreatment plus either laser disinfection or a calcium hydroxide pa…

This study tests whether using different nickel-titanium file systems, alone or with an XP-Endo Finisher irrigation device, can reduce pain after root canal treatment. Eighty adults with infected molars will be randomly assigned to one of four groups. Pain levels will be recorded…

This study compares two common root canal filling techniques—cold lateral condensation and warm vertical obturation—to see which causes less pain afterward. About 80 adults with infected but pain-free teeth will be randomly assigned to one method. Researchers will measure pain le…

This study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be treated and asked to rate their pain. The goal is to find a better way to man…

This study looks at two types of dental sealers used during root canal treatment to see which one leads to less pain afterward. Sixty adults with a painless tooth infection around the root tip will be randomly assigned to receive either a calcium-based bioceramic sealer or a resi…

This study looks at whether using different concentrations of sodium hypochlorite (a type of bleach) during root canal retreatment can change pain levels and certain nerve chemicals in the tooth. Sixty adults needing a repeat root canal will be randomly assigned to receive 1%, 2.…

This study looks at whether root canal treatment can reduce inflammation markers linked to heart disease in people with stable coronary artery disease and infected tooth roots. Eighty adults will either get immediate root canal treatment or wait three months. Researchers will mea…