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Cholesterol drug could help heal infected teeth

NCT ID NCT07256561

Disease control Sponsor: Hadeer Maher Mostafa Mohamed Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether simvastatin, a common cholesterol drug, can fight infection and reduce inflammation when placed inside a tooth during root canal retreatment. Fifty-four adults with a single-rooted tooth that had a failed root canal and a small area of bone loss around the tip will receive either simvastatin or a standard calcium hydroxide paste. The goal is to see if simvastatin improves healing of the bone and reduces infection better than the usual treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
simvastatin
What this could lead to
If it works, this could offer a better way to control infection and reduce inflammation during root canal retreatment, potentially improving healing.
What could go wrong
This is a small, early-stage trial with only 54 participants. Simvastatin is not approved for this use, and its effects inside a tooth may differ from its usual use. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients had anon contributory medical history. * Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems. * Single rooted teeth with type I root canal anatomy. * Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm. Exclusion Criteria: * Patients with known sensitivity to the pharmaceutical used in this trial * Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments) * Non restorable teeth * Presence of an associated sinus tract. * Advanced periodontal involvement * Teeth representing root fracture. * Pregnant women

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontically retard teeth Periapical radiolucency

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    RECRUITING

    Cairo, Egypt

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