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Blood clot upgrade: could CGF plugs revolutionize tooth extraction recovery?

NCT ID NCT07542795

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether placing a Concentrated Growth Factor (CGF) plug—made from the patient's own blood—into a fresh tooth socket can reduce pain and improve bone healing after a simple extraction. Ten healthy adults aged 20 to 50 will be followed for 3 months. The goal is to see if this simple, natural approach can make recovery smoother and preserve bone for future dental work.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Concentrated Growth Factor (CGF) plug made from the patient's own blood
What this could lead to
If it works, this could offer a simple way to reduce pain and keep bone healthy after a tooth extraction, which may help with future dental implants.
What could go wrong
This is a very small early study with only 10 people and no comparison group, so results may not apply widely. The CGF plug is made from your own blood, so risks are low but unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients (ASA I or II) * Age between 20 and 50 years * Require simple, non-surgical extraction of a single tooth * Presence of periapical radiolucency at the extraction site * Willingness to comply with follow-up and provide signed informed consent Exclusion Criteria: * • Systemic diseases (e.g., uncontrolled diabetes, bone metabolic disorders) * History of radiotherapy or chemotherapy * Use of medications affecting bone metabolism (e.g., bisphosphonates, chronic steroids) * Heavy smokers * Pregnant or lactating women * Poor oral hygiene or active acute infection/suppuration at the site

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone density and postoperative pain management Odontectomy (tooth extraction) Periapical radiolucency Socket preservation and healing following simple, non-surgical extraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cairo University Faculty of Dentistry

    Cairo, Egypt

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