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Which sealer causes less pain? new study aims to find out

NCT ID NCT07256691

Symptom relief Sponsor: Fatima Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two types of dental sealers used during root canal treatment to see which one leads to less pain afterward. Sixty adults with a painless tooth infection around the root tip will be randomly assigned to receive either a calcium-based bioceramic sealer or a resin-based sealer. Pain levels will be checked at 4, 24, and 48 hours after the procedure using a simple 0-10 scale. The goal is to help dentists choose the better material for patient comfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:Age 18-55 years. * Both genders. * Teeth diagnosed with asymptomatic apical periodontitis. * Teeth are asymptomatic (no pain on percussion or palpation). * Non-vital pulp (no response on Electric Pulp Testing). * Teeth with fully formed apices. * Teeth with Periapical Index (PAI) scores 2-4 on radiographs. Exclusion Criteria: * Medically compromised patients (e.g., those with immunosuppressive or systemic diseases, or on medications that may affect healing). * Patients who refuse to participate or are unable to communicate their symptoms (e.g., due to psychological disorders). * Teeth where full working length cannot be reached. * Periodontally compromised teeth (probing depth \>4 mm). * Complications during treatment (e.g., separation of a file, ledging). * Overfilling (filling beyond the radiographic apex) or short filling (\>2 mm from the radiographic apex).

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fatima Memorial Hospital

    RECRUITING

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.