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Bleach strength during root canal retreatment may affect pain, study finds

NCT ID NCT07453576

Knowledge-focused Sponsor: KEZBAN MELTEM ÇOLAK Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at whether using different concentrations of sodium hypochlorite (a type of bleach) during root canal retreatment can change pain levels and certain nerve chemicals in the tooth. Sixty adults needing a repeat root canal will be randomly assigned to receive 1%, 2.5%, or 5% bleach irrigation. Researchers will measure pain after the procedure and test tooth fluid for substances linked to inflammation and pain. The goal is to find the best concentration to minimize discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium hypochlorite (bleach) solution at 1%, 2.5%, or 5% concentration
What this could lead to
If successful, this could help dentists choose the best bleach concentration to reduce pain after root canal retreatment.
What could go wrong
This is a small, early-stage study with only 60 participants. It measures chemical markers, not direct pain relief, so results may not lead to clear treatment changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 and 65 years. * Systemically healthy individuals (ASA I or II) * Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth * Patients who provide written informed consent. Exclusion Criteria: * Patients with systemic diseases that may affect pain perception or inflammatory response. * Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment. * Pregnant or lactating women. * Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth. * Teeth with open apices or immature root development. * Presence of acute apical abscess with swelling or sinus tract. * Patients with known allergy to sodium hypochlorite. * Inability to achieve adequate isolation with rubber dam. * Patients unable to attend follow-up or complete pain assessment forms.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Persistent apical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Atatürk University Faculty of Dentistry, Department of Endodontics

    RECRUITING

    Erzurum, Erzurum, 25240, Turkey (Türkiye)

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