Childhood onset asthma

Researchers are testing whether a digital version of a transition program can help teenagers with chronic conditions like asthma or organ transplants move from pediatric to adult healthcare. The program includes a transition coordinator, education, peer meetings, and a personaliz…

This trial tests a school-based asthma program for children aged 2 to 12 in San Juan, Puerto Rico, who have poorly controlled asthma. The program, delivered by community health workers, includes staff training, child education, and caregiver support. Researchers compare a high-in…

This pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…

This trial tests whether a dedicated NHS environmental health clinic can help children with chronic respiratory conditions by reducing their exposure to air pollutants. Children aged 4-17 will wear personal monitors and have their homes assessed, then receive personalized reports…

This study tests whether azithromycin, an antibiotic, can reduce airway inflammation in children ages 3-17 hospitalized for critical asthma. One hundred participants will receive the drug for three days while researchers monitor inflammation markers and side effects. The goal is …

This trial tests whether a comprehensive school and home asthma program, called Asthma CHAMPS, can improve asthma control and reduce asthma-related absences, emergency visits, and hospitalizations for children in Baltimore City elementary schools. The program includes education f…

This study looks at whether inspiratory muscle training—exercises that strengthen breathing muscles—can improve asthma in children aged 6 to 17 with moderate to severe asthma. It compares two training intensities against a sham (inactive) device over 8 weeks. The trial also exami…

This trial tests a multilevel education program called ABC Asthma for staff and families at Head Start centers. The goal is to reduce asthma symptoms and school absences in low-income urban preschoolers with asthma. Researchers are working with 40 Head Start sites to see how well…

This study tests a smartphone app called SMART@Home designed to help teenagers with asthma manage their condition. The app sends daily reminders for medication and diary entries, provides educational content, and connects to Bluetooth devices like a spirometer to track lung funct…

This study tests whether school-based health centers can improve asthma care for 400 children with uncontrolled asthma from underserved communities. The program includes guideline-based assessments, directly observed preventive medication, and self-management support. The goal is…

This study tests whether low-cost fixes for dampness and mold in the home can improve asthma control in children from low-income families. About 80 kids with asthma will be split into two groups: one gets the home repairs right away, the other waits. Researchers will check asthma…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study tests whether having school staff supervise children taking their asthma medication can improve symptoms and reduce hospital visits. About 350 children aged 5-14 with poorly controlled asthma will either receive school-supervised therapy plus an educational workbook, o…

This study tests a program called TEACH-ER that provides asthma education in the emergency room and virtual follow-up visits at home. Researchers will enroll 430 children aged 3-12 with asthma to see if this approach reduces the need for future ER visits or hospital stays. The pr…

This study explores whether using connected inhalers that track medication use, combined with video doctor visits when problems arise, can manage childhood asthma as well as standard in-person care. Fifty children aged 4 to 12 with asthma will take part for 8 months. Half will us…

This study tests a program called PRAGMATIC-S that connects doctors' offices with schools to help children ages 4-12 better manage their asthma. The goal is to improve asthma control and quality of life by making sure kids get the right care in both places. About 420 children wit…

This study tests whether a new digital spacer (Whizz) helps children aged 5-16 with asthma use their inhaler correctly and stick to their medication, compared to a standard spacer. Researchers will also look for biomarkers in blood and breath to improve diagnosis and understand h…

This study tests whether a trained asthma navigator can help children aged 4-12 avoid repeat hospital visits after an asthma attack. Families in the Washington, DC area will be randomly assigned to receive either standard care or extra support from a navigator for 12 months. The …

This study tests whether adding soluble fiber (inulin) to the diet can improve asthma control in children aged 6 to 17. Participants will take a fiber or placebo drink for several weeks. Researchers will check asthma symptoms and analyze gut and nasal microbes to see if diet chan…

This study tests a program called CHAMPION that helps children with overweight or obesity and asthma live healthier lives. The program includes doctor visits, diet advice, and health coaching. Researchers want to see if doing the program entirely online works as well as meeting i…

This study tests whether a mobile app, inhaler sensors, and remote coaching from an asthma coordinator can help children ages 4-17 better manage their asthma. Eighty parent-child pairs will be split into two groups: one gets the full digital toolkit with coaching, the other gets …

This study tests two ways to reduce cockroach allergens in homes of children with asthma in New Orleans. One group gets a simple cockroach bait, the other gets a tailored plan including education, mattress covers, and air purifiers. Over 12 months, researchers will track asthma s…

Doctors often use a methacholine challenge to help diagnose asthma in children, but the standard breathing test requires strong cooperation and can fail if a child cannot blow hard enough. This study tests whether a gentler method called forced oscillation, which measures how the…

This study investigates whether using a breath test that measures airway inflammation (FeNO) can improve asthma management in children aged 6 to 14. Researchers will compare outcomes in children whose care includes regular FeNO monitoring against a similar group from the past who…

This study looks at whether measuring inflammation in the breath and blood can help doctors prioritize who gets lung tests first when asthma is suspected. About 1,500 people aged 6 and older will take part. The goal is to see if this approach reduces delays for those most at risk…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study tests a small wearable device called AeviceMD that listens to lung sounds and detects wheezing. Researchers want to see if the device is as accurate as a doctor using a stethoscope. About 160 children and adults with asthma will participate. If successful, the device c…

This study tests whether an eHealth app can help parents of children under 6 reduce their kids' exposure to second-hand smoke. About 160 families will use the app or receive standard care. The goal is to lower children's urine cotinine levels and prevent asthma and other diseases…

This study tests whether giving a soy isoflavone supplement to infants at high risk for asthma can reduce their chance of developing the condition. Researchers will give 65 babies either the supplement or a placebo twice daily for 7 months, tracking wheezing episodes and immune m…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study tests whether giving children aged 5-17 with severe asthma attacks early breathing support (called BPAP) in the emergency room is practical and safe. About 36 children will either get standard asthma care alone or standard care plus BPAP. The goal is to see if this app…

This study tests whether giving children with asthma and their families Air Quality Index (AQI) information helps improve asthma control. 351 children will receive either EPA or commercial AQI education plus an asthma action plan, or standard care. Over 48 weeks, researchers will…

This study tests whether a short-term therapy called Enhanced Brief Interpersonal Psychotherapy (IPT-B) can reduce depression in mothers of children with asthma. Sixty Black mothers who have mild to moderate depression and a child with asthma will either receive the therapy or us…

This study tests a new way to help teenagers with asthma feel more in control of their condition. Teens aged 12-18 will either get a standard doctor visit or a visit where their confidence in managing asthma is assessed and addressed. After three months, researchers will compare …

This study tests whether giving doctors extra training and electronic reminders helps them prescribe a modern asthma treatment called SMART for children with moderate to severe asthma. The study involves 18 children ages 5 to 18 at primary care clinics. Researchers will compare h…

This study tests two strategies to help doctors prescribe SMART therapy—a single inhaler for daily control and quick relief—for children with moderate to severe asthma. Researchers will use electronic reminders and education, plus a community health worker and nurse care manager,…

Researchers want to know if breathing patterns recorded while premature babies are in the neonatal intensive care unit relate to asthma, sleep-disordered breathing, and neurodevelopmental problems at preschool age. The study follows up to 500 children born before 29 weeks of preg…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This observational study will analyze samples from 160 children with asthma, protracted bacterial bronchitis, or chronic cough to find biomarkers that predict disease progression and treatment response. Participants will undergo a bronchoscopy to collect lung fluid and tissue sam…

This study investigates the range of symptoms children with newly diagnosed asthma may experience, including less common ones like recurrent pneumonia, chronic wet cough, or difficulty breathing in. By tracking 80 children aged 3 to 18, researchers aim to better understand how of…

This study follows 300 infants to understand how catching RSV very early (before 4 months old) versus later (after 6-9 months) affects their immune system and long-term health. Researchers will measure antibody responses and track asthma-like symptoms. The goal is to learn why ea…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study looks at the bacteria (microbiomes) in the airways of infants under 2 years old with severe asthma. Researchers will collect blood, nasal swabs, and sputum samples to understand how these microbiomes relate to the disease. The goal is to find new ways to improve care a…

This observational study enrolls 500 children aged 6-17 who come to the emergency department with an acute asthma attack. Researchers will check if doctors follow the latest GINA 2025 guidelines for diagnosis, treatment, and follow-up. The goal is to see if standardizing care imp…

This study follows 200 infants hospitalized with lower respiratory tract infections (like bronchiolitis) to see if lung ultrasound and special breathing tests can help doctors predict how sick a child will get and who might develop asthma later. Researchers will track symptoms, h…

This study will enroll 900 children aged 5-17 with asthma to see if remote monitoring—using routine health data and a smartphone app—can predict asthma attacks. Researchers will track whether this system reduces the number of attacks compared to past averages. A subset of high-ri…

This study tests a new care pathway for children having mild-to-moderate asthma attacks. The goal is to make sure every child gets the same high-quality treatment, like using a spacer with their inhaler. Researchers will track how well doctors follow the new plan and look for way…