Cerebrovascular disorder

This trial tests whether giving stroke or TIA survivors free smoking-cessation medications (like nicotine patches, bupropion, or varenicline) for 12 weeks helps them quit smoking more effectively than just giving a prescription. The study will compare quit rates and cost-effectiv…

This study tests a drug called Ir-CPI in 23 people who have had a bleeding stroke (intracerebral hemorrhage). The drug is given once through a vein over 48 hours, alongside standard care. The goal is to see if it is safe and can reduce swelling and further brain damage around the…

This pilot study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can improve arm and hand movement in people who had a stroke more than six months ago. The study enrolls 7 adults aged 18-80 with stable uppe…

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested whether using social networks (like family and friends) can help people at high risk for stroke stick to their medications and control risk factors after leaving the hospital. Researchers enrolled 720 patients and compared standard care with a social network-bas…

This completed trial tested a new stent (SINOMED SR) for removing blood clots in 218 people with acute ischemic stroke. The stent was used within 24 hours of symptom onset. The main goal was to see if the stent could successfully reopen blocked brain arteries. Researchers also tr…

This study tested a supplement called HOV-12020 (made from palm tocotrienols) in 50 adults aged 45-75 with CADASIL, a rare genetic disease that damages small blood vessels in the brain, leading to strokes and memory loss. The goal was to see if the supplement could reduce worseni…

This study tested a device called Artemis that removes blood clots from the brain through a small hole, instead of open surgery. It included 236 adults aged 18 to 80 with a specific type of brain hemorrhage. The goal was to see if this less invasive approach leads to better recov…

This study tested two extra treatments for people on dialysis for kidney failure. One adds a special filter (hemoperfusion) to clean more toxins from the blood, aiming to reduce heart and brain complications. The other gives a steady sugar solution during dialysis to help patient…

This study tested whether sildenafil, a drug used for erectile dysfunction, can reduce harmful pulsations in brain blood flow in 75 people who had a stroke or mini-stroke due to small vessel disease. Participants took sildenafil, a similar drug (cilostazol), or a placebo for thre…

This study tested whether the drug Mexidol (given first as injections, then as pills) can improve thinking and memory in people with chronic cerebral ischemia, a condition where the brain doesn't get enough blood flow. 318 adults aged 40-90 with mild to moderate cognitive impairm…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tested a 6-month program for 92 stroke survivors in Vietnam. The program included regular health checks, personalized rehabilitation exercises, and motivational interviewing to support mental health. Participants were compared to those receiving standard care. The goal…

This study looked at 150 stroke patients in a rehab hospital to see if changes in their ability to do daily activities, walk, balance, think, and use their hands were linked to whether they went home or to another facility after discharge. Researchers used existing medical record…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study investigates how sex and stress influence blood flow in the brain, and whether antioxidants can alter that regulation. Healthy adults aged 18 to 40 will take either an antioxidant cocktail or a placebo, then undergo MRI scans to measure brain blood flow under normal an…

This completed study followed 81 adults who had stroke-like symptoms to see how damage to the blood-brain barrier relates to white matter changes in the brain. Over 6 years, participants had regular MRI scans and thinking tests. The goal was to better understand why some people d…

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study tested whether a gentle, non-invasive brain stimulation technique called tACS could improve hand function in 20 stroke survivors. The stimulation targeted two key brain areas involved in movement planning. Researchers measured brain connectivity and hand movement patte…

This study followed 82 people with blocked arteries supplying the back of the brain to see if low blood flow raises the risk of stroke or mini-stroke. Participants had already experienced a stroke or transient ischemic attack (TIA) and had at least 50% blockage in those arteries.…

This study looked at how small blood vessels in the brain change after a stroke caused by small vessel disease. Researchers used a special 3D X-ray technique to take detailed pictures of these vessels. The goal was to learn more about the disease process, which could help doctors…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…