Cardiac rhythm disease

This early study tests a new catheter technique called VINTAGE for people with ventricular arrhythmia that hasn't improved with standard treatment. The procedure uses special catheters to reach and destroy heart tissue causing the abnormal rhythm. Thirty adults will be enrolled a…

This study tests a new system that combines a leadless pacemaker with a subcutaneous defibrillator to treat dangerously fast heart rhythms. The devices communicate wirelessly to deliver pacing therapy without wires inside the heart. About 300 people at risk for ventricular tachyc…

This study follows 2000 people who have or will get the OmniaSecure defibrillation lead, a wire that helps control dangerous heart rhythms. Researchers will track how often the lead causes problems over 5 years. The goal is to make sure the lead is safe and works as expected in e…

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This study is tracking 100 adults who receive an EluPro antibiotic-eluting envelope during implantation of a heart device (like a pacemaker). The envelope slowly releases antibiotics to prevent infection. Researchers are monitoring complication rates in real-world use to see how …

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This early study tests a new device called the FieldForce Ablation System in 35 people with atrial fibrillation (AFib). The device uses short electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The main goals are to see if it is safe and if it ca…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This early study tests a new type of lead (a wire) for an implantable cardioverter-defibrillator (ICD) in 19 people who need one. The lead is placed under the breastbone to deliver a shock if the heart beats dangerously fast. The goal is to see if it is safe and works well enough…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study tests a new, non-invasive ultrasound method called electromechanical wave imaging (EWI) to see if it can more accurately locate and diagnose heart rhythm problems compared to standard tests. About 322 adults already scheduled for a heart procedure will get an EWI scan …

This study aims to make MRI scans clearer for people with heart arrhythmia (irregular heartbeat). Researchers will test two special imaging methods on 135 participants—105 with arrhythmia and 30 healthy volunteers—to see if they reduce blurry images caused by the irregular rhythm…

This study is testing whether a wearable ring and a small body sensor can accurately diagnose sleep-disordered breathing, including sleep apnea. About 79 adults with suspected sleep apnea will wear the devices during an overnight sleep lab test. The goal is to see if the ring's r…

This study was designed to test a new portable ECG recorder called Hativ P30, which uses artificial intelligence to analyze heart rhythms. Researchers planned to compare its readings to a standard 12-lead ECG in adults, including those with and without arrhythmias. However, the s…

This study is testing whether a smart blood pressure cuff called the Withings BPM Core can accurately detect atrial fibrillation, a common heart rhythm problem. Researchers will compare the device's single-lead ECG readings to a standard 12-lead ECG in 160 adults. If it works wel…

This study tests a new device called the EDEN system that records and classifies electrical signals from the heart during medical procedures. About 50 adults having heart procedures for ventricular arrhythmia or pacing will participate. The device works alongside standard equipme…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study compares six different ECG patches that people wear for a week to monitor heart rhythms. Researchers want to see which patches give the clearest and most useful recordings. The study involves 150 adults aged 65 and older who already need heart monitoring as part of the…

This registry follows 545 people with arrhythmia who received a heart ablation using the DiamondTemp system. Researchers will track how many stay free of their heart rhythm problem and how many have serious side effects over 12 months. The goal is to see how well the device works…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study follows over 3,400 people who have already received the Aveir VR leadless pacemaker, a small device placed directly in the heart to treat slow heart rhythms. Researchers are using real-world medical records to check for complications up to 10 years after implantation. …

This study follows 50 athletes who had acute myocarditis (heart muscle inflammation) to see how often they develop dangerous heart rhythms. Participants wear a portable ECG monitor and do a treadmill stress test at 3 months and 1 year after their illness. The goal is to learn mor…

This study tests whether wearing a portable heart monitor for up to three months before a TAVI procedure can detect silent arrhythmias in people with severe aortic stenosis. The goal is to see if catching these hidden rhythm issues early can lead to treatments that improve outcom…

This study follows 1000 patients who had a standard aortic valve replacement (TAVR) to see how their heart rhythms change over a year. Researchers will track abnormal heartbeats using ECG monitors. The goal is to learn which patients are at risk for rhythm problems and how they r…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study follows 186 adults with atrial fibrillation who are having a heart ablation procedure. Doctors use an AI software to guide the treatment, and researchers track how well it works and any side effects over two years. The goal is to see if the AI helps improve outcomes an…

This study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells and then into heart cells to study how these diseases work and t…

This study gathers information from 1,000 adults who have or will receive a cardiac implantable electronic device (CIED) for heart rhythm problems like bradycardia or tachycardia. Researchers collect details about the device, the implant procedure, and patient characteristics to …

This study at Vanderbilt University Medical Center is looking at whether people with postural tachycardia syndrome (POTS) have higher levels of certain immune proteins that might affect their symptoms. Researchers will measure these proteins in blood samples and test how the hear…