Burn

This study looks at whether a specific type of breathing support (adaptive support ventilation) combined with carefully controlled fluid replacement can help adults with severe burns who need a breathing machine. The goal is to see if this approach improves oxygen levels, lung fu…

This study compares two ways of using breathing machines in adults with severe burns (covering 20% or more of the body). One method, called Adaptive Support Ventilation (ASV), automatically adjusts the machine's settings to the patient's needs. The other is standard lung-protecti…

This early-phase study tests whether a special dye (methylene blue) activated by blue light can safely reduce bacteria in burn wounds. About 50 adults with partial- or full-thickness burns will receive either the light treatment or light alone during two dressing changes. The goa…

This study tests a blood-filtering device called Efferon LPS in 50 people with severe burns. The goal is to see if it can reduce dangerous inflammation and prevent organ failure. Participants will either receive standard care or standard care plus the blood filter. The study focu…

This early study is testing a new dressing made from sodium hyaluronate and carbomer hydrogel for first and shallow second-degree burns. The goal is to see if it helps the burn heal completely within 50 days and reduces itching. The study will involve 30 adults with burn wounds o…

This study tests whether a computer program called Burn Navigator™ can better guide fluid replacement in adults with severe burns (covering at least 20% of the body) compared to the standard Parkland formula. The software uses real-time patient data to recommend hourly fluid amou…

This Phase 3 trial will test whether a graft made from donated amniotic tissue can help heal chronic wounds like diabetic foot ulcers and venous leg ulcers better than standard care. About 600 adults with wounds that haven't healed in 4 weeks will take part. The study will measur…

This study tests an AI-powered imaging device called DeepView to see if it can accurately assess burn injuries on the hands, head, and feet. Researchers will collect images from people with burns in these areas to train and improve the AI system. The goal is to help doctors make …

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

Many burn survivors live with persistent pain that disrupts daily life, and negative thoughts about pain can make it worse. Researchers are testing an 8-week cognitive behavioral therapy program delivered by video to see if it reduces pain interference and pain catastrophizing mo…

Researchers are testing custom silicone splints that fit inside the mouth to gently stretch facial tissue that has tightened or scarred after burns, trauma, or gunshot wounds. The study includes people aged 7 and older whose scars limit mouth opening, chewing, speaking, or facial…

This trial tests whether brief, video-guided jaw relaxation or breathing exercises can reduce anxiety and fear in children aged 4 to 10 who are having burn dressings changed. Children in a pediatric burn unit will be randomly assigned to one of three groups: jaw relaxation, breat…

This study tests whether adding a medication called 5-fluorouracil to a standard steroid treatment helps improve thick, raised burn scars more than the steroid alone. Both treatments are delivered through tiny holes made by a CO2 laser, which helps the medications reach deeper in…

This trial tests whether adding aromatherapy to standard pain medication helps reduce pain in young children (ages 2 months to 7 years) during their first burn dressing change. Participants are randomly assigned to receive either pain medication alone or pain medication plus a bl…

This study tests whether virtual reality (VR) can reduce pain, fear, and distress in children aged 6 to 12 during burn dressing changes. Half of the participants will receive standard care plus VR distraction, while the other half receives standard care alone. Pain, fear, and dis…

This study tests whether wearing a special cast for one week can improve thick, itchy burn scars. Researchers will compare treated scars to untreated ones in 38 adult burn survivors. They will measure changes in scar thickness, redness, moisture, itching, and pain.

This study tests whether Frenkel exercises—slow, controlled movements to improve coordination—can help people with lower limb burns regain balance and improve their quality of life. Seventy adults aged 25 to 45 with second-degree thermal burns on their legs will be split into two…

This study tests a new treatment for burn scars on the chest, shoulders, and back. Doctors will take a small amount of fat from the patient's belly or thigh, process it into a liquid rich in healing cells, and inject it into the scar. The goal is to improve the scar's look, feel,…

This study tests whether using a virtual reality headset or a smartphone during burn dressing changes can lower pain and anxiety. 99 adults with second-degree burns will be randomly assigned to VR, smartphone, or standard care. Pain and anxiety are measured right after the dressi…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study tests a new rehab program for adults with severe burns who are on breathing machines. The program uses brain stimulation, virtual reality, and special sedation to try to prevent muscle loss. Thirty patients will be split into two groups: one gets standard care, the oth…

This study tests whether a guided laughter exercise, called Laughie, can help people with second-degree burns feel less pain and anxiety during dressing changes. 88 adults will either watch and mimic a video of their own laughter before the procedure or receive standard care. The…

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…

This study investigates whether a topical cream containing amitriptyline, a drug typically used for depression and pain, can block the release of microvesicle particles (MVPs) from skin after a small thermal burn. Healthy adults aged 18-64 receive a tiny, controlled burn on their…

This pilot study tests whether a single 75mg dose of amitriptyline can reduce the release of microvesicle particles (tiny substances) from skin after a very small, controlled burn. Twenty healthy adults will receive either amitriptyline or a placebo, then a small heated rod creat…

This study looks back at medical records of about 1,400 burn patients treated at a hospital near a border. Researchers want to see if foreign-national patients have different outcomes, such as death rates or need for intensive care, compared to Turkish citizens. No new treatments…

This study will check if an Arabic version of the Michigan Hand Outcomes Questionnaire works well for people who have had hand burns. About 100 adults with second-degree burns on their dominant hand will fill out the questionnaire twice, one week apart. Researchers will see if th…

This study follows 236 severely burned patients who received lab-grown skin grafts (CEA or CDEA) between 1985 and 2023 at Swiss burn centers. Researchers will measure scar quality, skin thickness, elasticity, and check for skin tumors. The goal is to understand long-term outcomes…

This study looks at how different positions and positioning devices affect pressure on areas like the heels, tailbone, elbows, and back of the head in burn patients. Researchers will use a special pressure-sensing mat to find which setups create the least pressure. The goal is to…

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…