Can a common antidepressant calm burn damage? early study investigates
NCT ID NCT07640061
First seen Jun 23, 2026 · Last updated Jun 23, 2026
Summary
This pilot study tests whether a single 75mg dose of amitriptyline can reduce the release of microvesicle particles (tiny substances) from skin after a very small, controlled burn. Twenty healthy adults will receive either amitriptyline or a placebo, then a small heated rod creates a minor burn on their forearm. Skin samples will be taken to measure particle release. The study aims to understand the body's response to injury, not to treat burns directly.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Wright State University - Pharmacology Translational Unit
Fairborn, Ohio, 45324, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
amitriptyline
What this could lead to
If it works, this could point toward a way to reduce harmful particles released after burns, potentially improving healing.
What could go wrong
This is a very early, small pilot study with only 20 people. It tests a tiny controlled burn, not real-world injuries, and may not translate to actual burn care.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.