Bronchiectasis

This trial tests a new approach to pulmonary rehabilitation, a standard programme of exercise and education for people with chronic lung disease. The twist is that informal carers, often family members, join the education and support sessions. The goal is to see if this carer-inc…

This trial tests an inhaled investigational drug called ALX1 in adults with bronchiectasis, a chronic lung condition that causes coughing and mucus buildup. Participants receive either ALX1 or a placebo for 14 days. The study aims to find safe and effective doses for future resea…

This trial tests whether a special vibrating vest, worn around the chest, can improve lung function in children aged 6 to 12 with non-cystic fibrosis bronchiectasis — a condition where the airways are permanently widened and clogged with mucus. The vest shakes the chest at high f…

This phase 3 trial tests whether a daily tablet called florensocatib can reduce the number of lung flare-ups in people with bronchiectasis, a chronic lung condition. About 904 participants aged 12 to 85 will be randomly assigned to receive either the drug or a placebo for up to 7…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tests whether taking a low dose of the antibiotic azithromycin every day for a year can reduce the number of serious lung infection flare-ups in adults with non-CF bronchiectasis. About 500 participants will receive either azithromycin or a placebo pill, added to their…

This study tests whether children aged 6–12 with chronic lung infections (like bronchiectasis) can improve their exercise ability and lung clearance using online physiotherapy sessions. Over 12 weeks, 32 children will either receive remote guided breathing exercises and workouts …

This phase 3 trial tests whether taking the antibiotic moxifloxacin for 7 days every 8 weeks (for a year) can reduce lung infection flare-ups in people with non-cystic fibrosis bronchiectasis. 140 adults who have had at least two flare-ups in the past year will be randomly assign…

This pilot study will test a digital device that attaches to a standard COPD inhaler. The device coaches patients on proper inhaler technique and shares usage data with their healthcare team. Researchers want to see if this approach is practical and helps reduce hospital visits a…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study tests whether a 12-week telerehabilitation program—supervised resistance and endurance training done at home—can improve exercise capacity and quality of life in 80 adults with bronchiectasis. Participants are randomly assigned to either the training program or usual c…

This study tests whether a herbal medicine called Lifei Qingchang Granules can improve breathing and quality of life in people with stable bronchiectasis, a chronic lung condition. About 150 adults aged 18-75 who have had at least one flare-up in the past year will take either th…

This pilot study will test the Simeox 200, a device designed to help clear mucus from the lungs, in 35 adults with bronchiectasis who produce a lot of phlegm. Participants will use the device twice daily for two weeks, and researchers will measure how much mucus is cleared, along…

This study looks at whether adding expiratory muscle training (using a handheld device) to standard pulmonary rehabilitation can improve lung function, breathing strength, and exercise capacity in adults with bronchiectasis. Forty participants will be randomly assigned to rehab a…

This study will compare two methods of giving N-acetylcysteine—a drug that thins mucus—to 70 adults hospitalized with bronchiectasis. Half will receive the drug through a nebulizer (inhaled), and half through an IV. Researchers will measure how well each method reduces sputum thi…

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study will follow 100 adults hospitalized for a sudden worsening of bronchiectasis. Researchers will track how conditions like COPD, diabetes, and heart disease, along with disease severity, affect the need for intensive care, length of hospital stay, and risk of death. The …

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to find clues …

This study will examine tissue and blood samples from 105 adults having lung surgery to understand why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will compare three groups: those with lung disease and pulmo…