Herbal granules aim to ease breathing in lung disease trial
NCT ID NCT07523165
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a herbal medicine called Lifei Qingchang Granules can improve breathing and quality of life in people with stable bronchiectasis, a chronic lung condition. About 150 adults aged 18-75 who have had at least one flare-up in the past year will take either the granules or a placebo for 3 months, alongside standard chest clearance therapy. The main goal is to see if the treatment reduces symptoms like cough and shortness of breath.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 to 75 years old, regardless of sex. * Diagnosed with bronchiectasis confirmed by High-Resolution Computed Tomography (HRCT) scan. * Bronchiectasis is currently in the stable phase. * Experienced at least one acute exacerbation of bronchiectasis within the previous 12 months. * Diagnosed with the Traditional Chinese Medicine (TCM) syndrome of "Phlegm-Heat Obstructing the Lungs". * Able to understand the study protocol and voluntarily sign the informed consent form. Exclusion Criteria: * Allergic to any ingredients of the investigational drug or placebo. * Comorbid with other severe systemic diseases (e.g., coronary heart disease, stroke, severe hypertension \[systolic BP ≥ 180 mmHg or diastolic BP ≥ 110 mmHg\], active gastric ulcer, uncontrolled diabetes \[fasting venous blood glucose ≥ 10 mmol/L\], malignant tumors, abnormal liver or kidney function \[AST, ALT, or GGT \> 2 times the upper limit of normal; or serum creatinine \> 2 times the upper limit of normal\]) or psychiatric disorders. * Comorbid with asthma, allergic bronchopulmonary aspergillosis (ABPA), or active pulmonary tuberculosis. * Comorbid with chronic obstructive pulmonary disease (COPD) and presenting COPD as the primary clinical manifestation (as judged by the investigator). * Use of inhaled, oral, or intravenous antibiotics within 4 weeks prior to enrollment. * Type 2 respiratory failure requiring long-term non-invasive mechanical ventilation or oxygen therapy (\> 10 hours/day). * History of drug abuse, psychotropic drug dependence, or alcohol abuse. * Current smokers or those unable to stop smoking during the study. * Pregnant or lactating women, planning to become pregnant during the study, or refusing to use reliable contraceptive methods throughout the study period. * Participation in any other clinical trials within 3 months prior to enrollment. * Considered unsuitable for participation in this clinical study by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510170, China
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The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510260, China
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The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510150, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simpler antibiotic course clear lung infections as well as a stronger one?
- A new twist on lung rehab: helping the helpers
- Gum treatment may lower lung flare-ups in bronchiectasis patients
- Can a daily pill cut dangerous lung Flare-Ups in bronchiectasis?
- Lung inflammation may speed heart aging, study investigates
- Scientists track hidden threat of antibiotic resistance in lung patients