BRONCHIECTASIS

This study tests whether itraconazole, an antifungal drug, is safe and practical for people with bronchiectasis who have mold growing in their airways. About 30 adults will take the medication for 6 weeks. Researchers will track how many people join and stick with the treatment, …

This study tests a daily tablet called BI 1291583 in adults and teens aged 12 and older with bronchiectasis, a lung condition that causes frequent infections and breathing problems. The goal is to see if the medicine reduces the number of serious flare-ups compared to a placebo. …

This study tests a home-use breathing device called BiWaze Clear in 85 people with bronchiectasis. The device helps clear mucus and expand the lungs. Researchers will check if using it for 6 months reduces the number of serious lung flare-ups compared to the year before. Particip…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will measure LSI in 700 adults with various lung conditions and healthy volu…

This study will test if a smartphone app called AWARE can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers, to compare the app's results wit…

This study tests an inhaled drug called CHF6333 for safety and tolerability in healthy volunteers and people with bronchiectasis, a lung condition causing chronic cough and infections. The trial starts with single doses in healthy people and patients, then gives repeated doses to…

This study tests a new exercise program for adults with bronchiectasis, a chronic lung disease. The program combines breathing muscle training with core-strengthening exercises. Researchers want to see if it improves lung function, muscle strength, balance, and quality of life co…

This study compares two breathing support methods—high flow nasal cannula and non-invasive ventilation—for people with bronchiectasis who are having a severe flare-up. The goal is to see which device is more effective and easier for patients to use. Twenty adults admitted to the …

This study is developing a personalized digital breathing game that children with bronchiectasis can use at home on a phone or computer to help clear their airways. The goal is to see if this game can replace the need for a physiotherapist for daily airway cleaning. The study wil…

This study looks at whether using a handheld breathing device (oscillating PEP) helps children (ages 8+) and adults with bronchiectasis feel better day-to-day. Researchers will ask 60 participants about their quality of life before and after using the device. The goal is to see i…

This study looks at how nutrition affects the progression of bronchiectasis, a common lung disease. Researchers will measure things like arm and calf size, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung f…

This study is observing 750 adults with non-cystic fibrosis bronchiectasis to develop a model that can identify different types of the disease based on patient data. The goal is to help doctors predict how the disease will progress and tailor care more effectively. No new treatme…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18-80, including healthy volunteers, and trac…

This study looks at how heart problems impact the severity and quality of life in people experiencing a sudden worsening of bronchiectasis (a lung condition). Researchers will compare 30 participants with both bronchiectasis and heart conditions to a control group. The goal is to…

This study looks at 80 adults to compare the physical and mental health of people with NTM lung disease (a chronic lung infection) and those with bronchiectasis alone. Participants fill out questionnaires and do simple tests on exercise, strength, and nutrition in one visit. The …

This study is gathering information from 470 adults with various inflammatory lung diseases, including asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze medical history, lung function, and other health data to identify different disease pa…

This study looks at 150 adults with bronchiectasis, a long-term lung disease that causes coughing and breathing problems. Researchers want to understand how bacteria in the lungs and gut affect the disease and why some people get worse faster. They will collect sputum, stool, and…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants and compare them with healthy volunteers. The goal is to…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis, who may also have an infection from NTM bacteria. Researchers will collect sputum and airway samples from 200 participants to compare the lung microbiome of those w…

This study follows 900 people with bronchiectasis (damaged and infected airways) to learn why they get repeated lung infections. Researchers will collect blood, spit, and genetic samples from patients and their family members. No new treatments are tested; the goal is to find inh…

This study follows 1,850 people with bronchiectasis, a chronic lung condition, for three years. Researchers collect sputum samples monthly to analyze how bacteria in the lower airways evolve and adapt. The goal is to understand which bacterial changes lead to sudden worsening of …