Basal cell carcinoma

This study tests whether combining an immunotherapy drug (cemiplimab), a topical cream (imiquimod), and laser therapy before surgery can cure high-risk basal cell skin cancer. About 18 adults with large or difficult-to-treat tumors will receive the combination or immunotherapy al…

This early-stage trial is testing whether an oral probiotic called R-5780 is safe and tolerable when taken alongside a standard PD-1 checkpoint inhibitor in people with advanced solid tumors (like melanoma or certain skin cancers). About 33 adults whose cancer has not responded t…

This study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with two anti-rejection medications (sirolimus and prednisone) in kidney transplant recipients who have advanced skin cancer that cannot be surgically removed or has spread. The goal is to …

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This early-stage study tests a new drug called KUP-101A in 21 people with advanced skin cancers (like melanoma or Merkel cell carcinoma) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also measu…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This phase 2 trial tests three experimental drugs—L19IL2, L19TNF, or a combination—injected directly into skin tumors for people with advanced basal cell carcinoma who cannot have surgery or radiation. About 180 participants will receive weekly injections for four weeks and be fo…

This phase 2 trial tests whether a combination of two immunotherapy drugs (Opdualag) works better than one drug (nivolumab) alone when given before surgery for high-risk basal cell carcinoma. About 30 people with large or hard-to-treat skin cancers will receive either the combo o…

This phase 2 trial tests a new drug combination, L19IL2/L19TNF, injected directly into skin tumors. It is for people with advanced basal cell carcinoma that has worsened despite or cannot tolerate standard treatments. The study will enroll 92 participants and track how many respo…

This study tests an experimental mRNA therapy called mRNA-4359, given alone or with standard immunotherapy drugs, in people with advanced solid tumors (like melanoma, lung cancer, or colorectal cancer). The main goals are to find a safe dose and see if the treatment can shrink tu…

This study tests a new device that delivers a special type of radiation directly into skin tumors. The goal is to see if it can shrink or control the cancer. The study is for adults with certain types of skin cancer, including squamous cell carcinoma and basal cell carcinoma. Par…

This study tests a device called DaRT that delivers a unique type of radiation (alpha particles) directly into tumors. It is designed for people with certain skin cancers, mouth cancers, or soft tissue sarcomas that are accessible for direct injection. The goal is to see if this …

This phase 2 trial tests whether the immunotherapy drug nivolumab, alone or combined with relatlimab or ipilimumab, can shrink tumors in people with advanced basal cell carcinoma that cannot be removed by surgery or has spread. About 57 participants will receive one of the drug c…

This study compares four different dosing schedules of the drug vismodegib in people with advanced basal cell carcinoma. The goal is to see if personalized, intermittent dosing works as well as or better than standard continuous dosing while being easier to tolerate. About 34 adu…

This phase 2 trial is testing the drug cemiplimab as a first-line treatment for people with advanced basal cell carcinoma who have not received prior therapy. The study will enroll 34 participants and measure how many patients see their tumors shrink or disappear after six months…

This early-phase study tests a combination of blue-light photodynamic therapy (a light treatment that kills cancer cells) and the drug sonidegib for people with multiple basal cell carcinomas. The goal is to see if this approach can effectively treat the cancers while avoiding th…

This study is testing a device called DaRT that delivers alpha radiation directly into tumors. It is for people with certain skin cancers, mouth cancers, or soft tissue sarcomas that are up to 7 centimeters in size. The goal is to see if the tumors shrink and to check for side ef…

This study is for people with advanced basal cell skin cancer that has completely disappeared after taking targeted pills (vismodegib or sonidegib). The problem is that the cancer often returns when the pills are stopped. Researchers want to see if giving a short course of radiat…

This study tests whether a special laser followed by tirbanibulin ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and, if needed, apply the ointment for…

This study tests whether two-photon fluorescence microscopy can accurately diagnose skin biopsies, including basal cell carcinoma, squamous cell carcinoma, and melanocytic lesions. Researchers will compare images from this technique with standard pathology results to measure its …

This study tests whether a machine learning model can accurately diagnose two common types of skin cancer—basal cell carcinoma and squamous cell carcinoma—by analyzing images from a special microscope (two-photon microscopy) that scans skin biopsy samples. The goal is to see if t…

This pilot study is testing a handheld imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. Researchers will enroll 60 adults who are already scheduled for Mohs surgery. The goal is to find out if the images are good…

This pilot study is testing whether a handheld laser probe, called Raman spectroscopy, can measure the size of skin cancer tumors. Twenty people with basal or squamous cell carcinoma who are already scheduled for brachytherapy will have their tumors scanned with the probe. The go…

This study tests whether a daily application of 5% niacinamide cream can prevent skin cancer in organ transplant recipients, who are at high risk due to long-term immune-suppressing drugs. Twenty adult transplant recipients with a history of precancerous skin spots and at least o…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests three non-invasive imaging devices on adults with basal cell carcinoma, the most common skin cancer. Researchers measure how long each scan takes, how comfortable it feels, and how well the tools work on different body areas. Participants attend one 40-minute vis…

This study tests whether artificial intelligence (AI) can help surgeons analyze microscope images of skin cancer tissue during surgery. The goal is to give surgeons real-time feedback so they can remove all cancer cells in one go. The trial will enroll 1,000 people with basal cel…

This study tests whether taking high-dose vitamin D for 6 days before photodynamic therapy (PDT) can improve the immune system's ability to fight nonmelanoma skin cancer. About 54 adults scheduled for Mohs surgery will be randomly assigned to vitamin D or placebo. Researchers wil…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study aims to validate a French version of the Nasal Reconstruction FACE-Q questionnaire, which measures how patients feel about their appearance, quality of life, and side effects after nasal reconstruction or prosthetic rehabilitation following nasal skin cancer surgery. A…

This study tests whether an artificial intelligence (AI) model can accurately classify basal cell carcinoma (a common skin cancer) as low-risk or high-risk using dermoscopic images. Researchers will also see if the AI can predict specific subtypes of the cancer. The model's perfo…

This study tracks 70 skin cancer patients to see how long it takes to get insurance approval for off-label neoadjuvant therapy (treatment before surgery). Researchers will measure approval times, out-of-pocket costs, and whether delays lead to worse surgical outcomes. The goal is…

This study aims to find out how often Muir-Torre syndrome (MTS) occurs in people who already have Lynch syndrome, a genetic condition that raises cancer risk. Researchers will examine skin lesions and tumors from 150 participants to see if they are linked to MTS. The goal is to b…

This study is building a large French database of patients with three rare skin cancers: Merkel cell carcinoma, advanced basal cell carcinoma, and cutaneous adnexal carcinomas. Researchers will track up to 9,000 participants to learn how these cancers behave, what factors affect …

This study aims to develop an artificial intelligence (AI) algorithm that analyzes skin damage (dermatoheliosis) around a melanoma scar to predict whether a patient will respond to anti-PD-1 immunotherapy. Researchers will collect photos and medical data from 700 adults with adva…

This study is testing a new predictive model that analyzes tumor samples to forecast whether a patient with melanoma or other skin cancers will respond to immunotherapy. Researchers will compare the model's predictions with actual patient outcomes over six months. The goal is to …