Aortic valve disorder

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested whether the anesthetic sevoflurane protects the heart better than propofol during aortic valve replacement surgery. 82 patients were randomly assigned to receive either sevoflurane or propofol during and after surgery. The researchers measured troponin levels, a…

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. R…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested a special heart-protection method given during heart surgery to see if it could reduce damage to the heart muscle. 210 adults having aortic valve surgery took part. Researchers measured a protein called troponin I in the blood for 72 hours after surgery to check…

This study looked at how safe and effective Abbott's Regent mechanical heart valve is for Chinese patients needing a new aortic valve. Researchers followed 200 adults who received the valve to track valve-related deaths and the need for repeat surgery. The goal was to confirm the…

This study looked at two surgical options for replacing a worn-out aortic heart valve in people aged 60-74. Researchers compared a standard stented biological valve with a donated human valve (allograft) to see which led to better survival and fewer complications. The goal was to…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

This study looked at whether motivational coaching and a home exercise program can help older adults become more active after a minimally invasive heart valve replacement called TAVR. Forty people who had the procedure took part. The goal was to see if these programs are practica…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study looked at the bacteria living on the skin of 100 patients scheduled for a heart valve replacement procedure called TAVI. The goal was to find out which bacteria are most common in the groin area, where the doctor inserts the new valve. This information can help doctors…

This study looked back at 198 patients who had a sutureless aortic valve replacement to see how often they developed heart rhythm problems. These newer valves are faster to implant but have a metal frame that might affect the heart's electrical system. The goal was to better unde…

This study collected information from multiple hospitals on the Cor-Knot® device, which automatically ties knots during heart valve surgery. The goal was to see how safe and effective it is. Over 550 adults having planned valve surgery took part. The main focus was on whether lea…

This study collected blood and tissue samples from 91 adults with aortic valve disease to look for genetic differences that might explain why some develop aortic aneurysms. Researchers compared gene activity in people with bicuspid valves, tricuspid valves, and healthy controls. …

This study looked at 38 adults who had heart surgery to better understand the heart damage that can occur. Researchers used cardiac MRI scans and blood tests for troponin (a heart damage marker) to measure and compare the extent of injury. The goal was to improve knowledge of how…